Abstract: A stabilized complex comprising a growth hormone and an aromatic aldehyde. Specifically, the complex comprises porcine somatotropin and a substituted benzaldehyde and to a method of providing a prolonged release of the somatotropin and improved feed efficiency in animals.
Type:
Grant
Filed:
June 11, 1992
Date of Patent:
March 30, 1993
Assignee:
SmithKline Beecham Corporation
Inventors:
Michael T. Clark, Robert J. Gyurik, Sharon K. Lewis, Marianne C. Murray, Matthew J. Raymond
Abstract: Prodrug carbamate derivatives of fenoldopam which provide fenoldopam plasma levels of similar magnitude and over a much longer period of time than the parent compound. An absence of a high initial peak effect associated with the parent compound is noted. A lead compound of the series is 6-chloro-7,8-diethylcarbamoyl-1-(4'-ethylcarbamoylphenyl)-2,3,4,5-tetrahyd ro-1H-3-benzazepine. The R-enantiomers are the most biologically active and preferred compounds.
Type:
Grant
Filed:
January 27, 1989
Date of Patent:
August 29, 1989
Assignee:
SmithKline Beckman Corporation
Inventors:
Dimitri Gaitanopoulos, Bruce Mico, Joseph Weinstock
Abstract: A pharmaceutical composition suitable for oral adminstration comprising particulate cimetidine suspended in an aqueous phase containing a buffer which maintains the pH at greater than 7 and a suspending agent.
Type:
Grant
Filed:
June 2, 1987
Date of Patent:
August 29, 1989
Assignee:
Smith Kline Dauelsberg GmbH
Inventors:
Eberhard F. Gottwald, Horst M. Machoczek
Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
Abstract: The invention relates to an effervescent couple which comprises a mixture of mono-and di-alkali metal citrate as well as to a process for preparing same. The process comprises partially neutralizing citric acid by reacting an alkali metal carbonate or bicarbonate with citric acid and water and controlling the amount of carbon dioxide released during the reaction by stopping the reaction when a certain amount of citric acid has been neutralized. In a preferred embodiment the reaction is stopped when from about 24% to about 54% of the potential amount of carbon dioxide has been released.
Abstract: A method and slide for collecting and testing fecal occult blood which permits multiple analyses of a single fecal sample. The slide contains a pocket-like member on a portion of the inside front cover of the slide. An absorbent insert is disposed in the pocket. When the cover is in a closed position the pocket overlies the fecal smear on the specimen viewing sheet and the insert can be removed from the pocket. This design permits an analysis to be done on the specimen receiving sheet of the slide together with a second confirmatory test on the insert.
Type:
Grant
Filed:
November 24, 1986
Date of Patent:
December 6, 1988
Assignee:
SmithKline Beckman Corporation
Inventors:
Josefina T. Baker, Joseph F. Pagano, Ronald J. Schoengold
Abstract: A novel process for preparing cimetidine polymorph "B" comprises precipitating cimetidine from an aqueous-alcoholic solution of an acid addition salt. The precipitation is conducted at a temperature of above 15.degree. C.
Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
Abstract: Compositions and methods useful for enhancing the transdermal and transmembrane drug delivery of topical and systemic agents. The compositions and methods comprise the active agent together with an effective amount of certain amides of heterocyclic amines as defined herein as penetration enhancers and topically administering to human or animal skin or other membranes the resulting compositions.
Abstract: A tamper evident seal for containers having a plastic shrink sleeve placed around the cap and neck and extending over the shoulder. A paper label is placed over a portion of the sleeve to prevent the sleeve from being removed intact. The sleeve has zigzag, saw-tooth perforations above and below a median line. The perforations are between the shoulder and cap of the container. When the cap is twisted and removed the plastic sleeve is randomly fragmented making it difficult, if not impossible to match in any attempt to reseal the container.
Abstract: Compositions and methods useful for improved and controlled transdermal and transmembrane drug delivery of topical and systemic agents. The compositions and methods comprise a pharmacologically active drug together with a non-toxic pharmaceutically acceptable ion exchange resin, and a salt in a gel-forming vehicle and topically administering to human or animal skin or other membranes the resulting compositions. If desired, a penetration enhancer may also be employed in the compositions of this invention.
Abstract: 6-Chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepine-N-oxide is prepared by mild oxidation of the corresponding amine. It has been found to have prolonged .alpha..sub.2 -antagonistic or antihypertensive activity.
Abstract: A method and device for separating blood into fluid and cellular fractions for diagnostic tests. The whole blood is introduced to a carrier containing a layer of carbohydrate which results in the rapid separation of the fluid from the cellular fractions. In a preferred embodiment, the device is fabricated in a sandwich design containing layers of carbohydrate and reagent material between two layers of plastic.
Type:
Grant
Filed:
April 11, 1985
Date of Patent:
July 7, 1987
Assignee:
SmithKline Diagnostics, Inc.
Inventors:
Myron C. Rapkin, Ronald J. Schoengold, David R. Shockey, Pierre C. Van Rysselberghe
Abstract: Certain 2-amino-6-.omega.-aminoethylphenols and thiophenols are intermediates for preparing D.sub.2 -dopamine agonistic aminoethyl substituted 1,3-benzthiazol- and 1,3-benzoxazol-2(3H)-ones.
Abstract: 9-Azido-6-halo-3-lower alkyl-2,3,4,5-tetrahydro-1H-3-benzazepines are prepared from their 9-amino congeners. The compounds are useful as photoaffinity probes for .alpha..sub.2 -adrenoceptor sites in biological samples.