Patents Represented by Attorney Joseph A. Marlino
  • Patent number: 4384003
    Abstract: A vaginal contraceptive suppository having both a rapid release of active ingredient and prolonged duration of effectiveness. The suppository comprises a mixture of sodium starch glycolate, a thickening agent and a vegetable oil base combined with a spermicide.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: May 17, 1983
    Assignee: Menley & James Laboratories, Ltd.
    Inventors: Michael S. Kazmiroski, Wilmer E. Latshaw
  • Patent number: 4382064
    Abstract: Specimen test slides for occult blood having a receiving sheet between a front panel and a rear panel with openings in the front and rear panels and pivotal covers coated with 2,6-di-tert-butyl-p-cresol to cover said openings.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: May 3, 1983
    Assignee: SmithKline Instruments, Inc.
    Inventors: Michael B. Detweiler, Paul J. Lawrence, Charles W. Townsley
  • Patent number: 4376111
    Abstract: Orally administrable pharmaceutical dosage units having a shape such that its most stable position on a horizontal flat surface is tilted. The units may be tablets, capsules, cachets, wafers, lozenges or analogous confections and candies. For the dosage unit to tilt it has a main body which has projections on its surfaces capable of acting as fulcra. Preferably the dosage units are tablets which have dome or pyramidal shaped projections centrally located on its surfaces. The dosage units are prepared according to the standard procedures of the pharmaceutical art. In the case of tablets, the granulation is compressed employing the appropriately shaped punches and dies.
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: March 8, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Patent number: 4365970
    Abstract: An improved specimen test slide having a front panel and a rear panel. The front panel has one or more openings. Sheet means carrying a test reagent underlie each of these openings for reception of a specimen. A hinged cover overlies the openings. The rear panel has flap means opposite said openings which is pivotable to expose the underside of the sheet to permit application of a developing solution. The underside of the sheet which faces the rear panel also has a control area positioned on a portion thereof at some distance from the portions of the sheet underlying the openings of the front panel. The control area contains positive and negative monitors.
    Type: Grant
    Filed: May 1, 1981
    Date of Patent: December 28, 1982
    Assignee: SmithKline Instruments, Inc.
    Inventors: Paul J. Lawrence, Charles W. Townsley
  • Patent number: 4352809
    Abstract: Method of producing alpha.sub.2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds.
    Type: Grant
    Filed: September 4, 1981
    Date of Patent: October 5, 1982
    Assignee: Smithkline Corporation
    Inventors: William E. Bondinell, Robert M. DeMarinis, Jacob P. Hieble, Robert G. Pendleton
  • Patent number: 4341786
    Abstract: Octahydrobenzo[f]quinoline compounds having 7- and 10-substituents are centrally acting alpha.sub.1 agonists.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: July 27, 1982
    Assignee: SmithKline Corporation
    Inventors: Robert M. DeMarinis, Dinubhai H. Shah
  • Patent number: 4329317
    Abstract: Specimen test slides for occult blood having a receiving sheet between a front panel and a rear panel with openings in the front and rear panels and pivotal covers coated with 2,6-di-tert-butyl-p-cresol to cover said openings.
    Type: Grant
    Filed: January 29, 1981
    Date of Patent: May 11, 1982
    Assignee: Smithkline Instruments, Inc.
    Inventors: Michael B. Detweiler, Paul J. Lawrence, Charles W. Townsley
  • Patent number: 4320148
    Abstract: 2-Aminotetralin compounds having 5- and 8- substituents are centrally acting alpha.sub.1 agonists.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: March 16, 1982
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Patent number: 4272531
    Abstract: 3,3'-Bis-Methylene-1,3-benzothiazine compounds are inhibitors of phenylethanolamine N-methyl-transferase.
    Type: Grant
    Filed: June 26, 1980
    Date of Patent: June 9, 1981
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Patent number: 4258049
    Abstract: Thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyltransferase.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: March 24, 1981
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Gerald R. Girard
  • Patent number: 4255413
    Abstract: A gelatin capsule unit dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the addition of a combination of a surfactant and a carbonate or bicarbonate salt as diluents.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: March 10, 1981
    Assignee: SmithKline Corporation
    Inventors: Elisabeth S. Rattie, Louis J. Ravin
  • Patent number: 4242346
    Abstract: Bis-2N-alkylene tetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyl-transferase.
    Type: Grant
    Filed: December 19, 1979
    Date of Patent: December 30, 1980
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Patent number: 4228170
    Abstract: 1,2,3,4-Tetrahydroisoquinoline compounds having 7- and/or 8-sulfur substituents are inhibitors of phenylethanolamine N-methyltransferase.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: October 14, 1980
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • Patent number: 4218464
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using novel 2,3-dihydro-1H-isoindole compounds having 4- and 5-substituents.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: August 19, 1980
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • Patent number: 4210587
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylaminoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: July 1, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Patent number: 4208430
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using substituted carbamimidothioic acid phenylalkyl esters.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: June 17, 1980
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • Patent number: 4200754
    Abstract: A novel process for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline by cyclizing N-acetyl-2,3-dichlorobenzylaminoacetaldehyde dimethyl acetal with a Lewis acid, reducing, and hydrolyzing the resulting acylated isoquinoline is disclosed.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: April 29, 1980
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Carl D. Perchonock
  • Patent number: D269712
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Patent number: D269713
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Patent number: D269719
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey