Abstract: A vaginal contraceptive suppository having both a rapid release of active ingredient and prolonged duration of effectiveness. The suppository comprises a mixture of sodium starch glycolate, a thickening agent and a vegetable oil base combined with a spermicide.
Type:
Grant
Filed:
June 29, 1981
Date of Patent:
May 17, 1983
Assignee:
Menley & James Laboratories, Ltd.
Inventors:
Michael S. Kazmiroski, Wilmer E. Latshaw
Abstract: Specimen test slides for occult blood having a receiving sheet between a front panel and a rear panel with openings in the front and rear panels and pivotal covers coated with 2,6-di-tert-butyl-p-cresol to cover said openings.
Type:
Grant
Filed:
February 11, 1982
Date of Patent:
May 3, 1983
Assignee:
SmithKline Instruments, Inc.
Inventors:
Michael B. Detweiler, Paul J. Lawrence, Charles W. Townsley
Abstract: Orally administrable pharmaceutical dosage units having a shape such that its most stable position on a horizontal flat surface is tilted. The units may be tablets, capsules, cachets, wafers, lozenges or analogous confections and candies. For the dosage unit to tilt it has a main body which has projections on its surfaces capable of acting as fulcra. Preferably the dosage units are tablets which have dome or pyramidal shaped projections centrally located on its surfaces. The dosage units are prepared according to the standard procedures of the pharmaceutical art. In the case of tablets, the granulation is compressed employing the appropriately shaped punches and dies.
Type:
Grant
Filed:
June 3, 1981
Date of Patent:
March 8, 1983
Assignee:
Smith Kline & French Laboratories Limited
Abstract: An improved specimen test slide having a front panel and a rear panel. The front panel has one or more openings. Sheet means carrying a test reagent underlie each of these openings for reception of a specimen. A hinged cover overlies the openings. The rear panel has flap means opposite said openings which is pivotable to expose the underside of the sheet to permit application of a developing solution. The underside of the sheet which faces the rear panel also has a control area positioned on a portion thereof at some distance from the portions of the sheet underlying the openings of the front panel. The control area contains positive and negative monitors.
Abstract: Specimen test slides for occult blood having a receiving sheet between a front panel and a rear panel with openings in the front and rear panels and pivotal covers coated with 2,6-di-tert-butyl-p-cresol to cover said openings.
Type:
Grant
Filed:
January 29, 1981
Date of Patent:
May 11, 1982
Assignee:
Smithkline Instruments, Inc.
Inventors:
Michael B. Detweiler, Paul J. Lawrence, Charles W. Townsley
Abstract: A gelatin capsule unit dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the addition of a combination of a surfactant and a carbonate or bicarbonate salt as diluents.
Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using novel 2,3-dihydro-1H-isoindole compounds having 4- and 5-substituents.
Type:
Grant
Filed:
March 2, 1979
Date of Patent:
August 19, 1980
Assignee:
SmithKline Corporation
Inventors:
William E. Bondinell, Robert G. Pendleton
Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylaminoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using substituted carbamimidothioic acid phenylalkyl esters.
Type:
Grant
Filed:
March 15, 1979
Date of Patent:
June 17, 1980
Assignee:
SmithKline Corporation
Inventors:
William E. Bondinell, Robert G. Pendleton
Abstract: A novel process for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline by cyclizing N-acetyl-2,3-dichlorobenzylaminoacetaldehyde dimethyl acetal with a Lewis acid, reducing, and hydrolyzing the resulting acylated isoquinoline is disclosed.