Patents Represented by Attorney Joseph A. Marlino

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  • Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase
    Patent number: 4192888
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 2-indanamine compounds having 4 and/or 5 substituents.
    Type: Grant
    Filed: April 10, 1978
    Date of Patent: March 11, 1980
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • 1-(2-Sulfamidoethyl)-1,4-dihydro-5H-tetrazole-5-thione
    Patent number: 4174323
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a sulfamidoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: November 13, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 3-(Carboxymethyl)thio-1H-1,2,4-triazol-5-thione
    Patent number: 4174324
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylthio substituted triazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: November 13, 1979
    Assignee: Smithkline Corporation
    Inventor: David A. Berges
  • 2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones
    Patent number: 4172890
    Abstract: Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.
    Type: Grant
    Filed: May 11, 1978
    Date of Patent: October 30, 1979
    Assignee: SmithKline Corporation
    Inventor: Kenneth G. Holden
  • Substituted 2H-pyran-2,6(3H)-dione derivatives
    Patent number: 4160021
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: July 3, 1979
    Assignee: SmithKline Corporation
    Inventor: Kenneth M. Snader
  • 7-Dithioacetamido cephalosporins and pharmaceutical compositions and methods employing them having antibacterial activity
    Patent number: 4137314
    Abstract: Novel cephalosporins having a dithioacetamido substituent at the 7-position are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: January 30, 1979
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • 4 AND 5-Halo substituted 2-indanamine compounds
    Patent number: 4128666
    Abstract: 2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.
    Type: Grant
    Filed: August 18, 1977
    Date of Patent: December 5, 1978
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • 7-Acylamino-3-[[3-(carboxymethyl)thio-1H-1,2,4-triazol-5-yl]thiom ethyl]-3-cephem-4-carboxylic acids
    Patent number: 4117124
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylthio substituted triazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: September 26, 1978
    Assignee: SmithKline Corporation
    Inventor: David Alan Berges
  • 7-Acylamino-3-[1-[2-(carboxymethylamino]ethyl) tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids
    Patent number: 4117125
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylaminoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: June 24, 1977
    Date of Patent: September 26, 1978
    Assignee: SmithKline Corporation
    Inventor: David Alan Berges
  • 7-Acylamino-3-[1-(2-sulfamidoethyl)tetrazol-5-ylthiomethyl]-3- cephem-4-carboxylic acids
    Patent number: 4117123
    Abstract: Novel cephalosporins having various acyl substituents at the 7- position and a sulfamidoethyl substituted tetrazolylthiomethyl group at the 3- position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: June 9, 1977
    Date of Patent: September 26, 1978
    Assignee: SmithKline Corporation
    Inventor: David Alan Berges
  • 2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones
    Patent number: 4108989
    Abstract: Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.
    Type: Grant
    Filed: April 1, 1977
    Date of Patent: August 22, 1978
    Assignee: SmithKline Corporation
    Inventor: Kenneth George Holden
  • Method of preparing aryloxybenzoic and arylthiobenzoic acids
    Patent number: 4094900
    Abstract: Novel process for preparing aryloxybenzoic and arylthiobenzoic acids by reacting 2-chlorobenzoic acid with substituted phenols or thiophenols in the presence of an alkali metal iodide and a base.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: June 13, 1978
    Assignee: SmithKline Corporation
    Inventors: Elvin Lowell Anderson, Gerald Aloysius Connelly
  • Antiarthritic compositions comprising bis[(trialkyl-phosphine)gold(I)]sulfides and methods of producing antiarthritic activity
    Patent number: 4093719
    Abstract: Pharmaceutical compositions having antiarthritic activity comprising Bis[(Trialkylphosphine)Gold(I)]Sulfides and methods of producing antiarthritic activity by administering internally, preferably orally, said compositions.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 6, 1978
    Assignee: SmithKline Corporation
    Inventor: David Taylor Hill
  • Folic acid derivatives and use in radio-assay
    Patent number: 4091087
    Abstract: Novel folic acid derivatives useful for radioassaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.
    Type: Grant
    Filed: July 28, 1976
    Date of Patent: May 23, 1978
    Assignee: Smith Kline Instruments, Inc.
    Inventors: M. James Barrett, Joseph I. De Graw
  • Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
    Patent number: 4089961
    Abstract: Tricyclic quinolizidine derivatives administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity essentially free of extrapyramidal symptoms.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 16, 1978
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, John Joseph Lafferty
  • Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
    Patent number: 4073912
    Abstract: Novel piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity essentially free of extrapyramidal symptoms.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 14, 1978
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, John J. Lafferty
  • Apparatus and method for oral dosing
    Patent number: 4059111
    Abstract: A method and apparatus for the oral dosing of animals, such as cattle, which comprises a substantially U-shaped conduit adapted to be passed into the mouth of the animal so that the leading end points in the direction of the animal's throat and the rear end projects from the side of the animal's mouth. A suitable substance is passed via the conduit into the animal's mouth.
    Type: Grant
    Filed: May 25, 1976
    Date of Patent: November 22, 1977
    Assignee: Smith Kline & French (Proprietary) Limited
    Inventor: Frans P. G. Erasmus
  • Skeletal muscle relaxant compositions comprising .alpha.,.alpha.-diphenyl-3-tropidineethanol and methods of producing skeletal muscle relaxation
    Patent number: 4058615
    Abstract: Pharmaceutical compositions having direct acting skeletal muscle relaxant activity comprising .alpha.,.alpha.-diphenyl-3-tropidineethanol and methods of producing skeletal muscle relaxant activity by administering internally said compositions.
    Type: Grant
    Filed: September 28, 1976
    Date of Patent: November 15, 1977
    Assignee: SmithKline Corporation
    Inventors: Peter Tone Ridley, Edwin Frank Weidley
  • 7-Dithioacetamido cephalosporins
    Patent number: 4058609
    Abstract: Novel cephalosporins having a dithioacetamido substituent at the 7-position are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: June 28, 1976
    Date of Patent: November 15, 1977
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Antiarthritic compositions comprising bis-coordinated gold(1+) salts and methods of producing antiarthritic activity
    Patent number: 4057630
    Abstract: Pharmaceutical compositions having antiarthritic activity comprising phosphine or phosphite bis-coordinated gold(1+) salts and methods of producing antiarthritic activity by administering internally, preferably orally, said compositions.
    Type: Grant
    Filed: August 2, 1976
    Date of Patent: November 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David Taylor Hill