Patents Represented by Attorney Joseph J. Borovian

Find this attorney in the Justia Lawyer Directory

  • Process for preparing the R- and S-isomers of 2-hydroxy-methyl-2-octadecyloxymethyl-tetrahydrofuran and their use in preparing stereoisomers of pharmacologically active compounds
    Patent number: 5208352
    Abstract: An improved process for preparing the R- and S-isomers of 2-hydroxymethyl-2-octadecyloxymethyl-tetrahydrofuran, a critical step of which involves the preparation of the R- and S-isomers of 2-[3-(1-methoxy-1-methylethoxy)]propyl-oxiranemethanol employing metal-catalyzed Sharpless epoxidation. In addition, the invention relates to the use of the R- and S-isomers of 2-hydroxymethyl-2-octadecyloxymethyl-tetrahydrofuran in preparing stereoisomers of pharmacologically active compounds, and to the R- and S-isomers of 2-[3-(1-methoxy-1-methylethoxy)]-propyl-oxiranemethanol as novel compounds.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: May 4, 1993
    Assignee: Sandoz Ltd.
    Inventors: Chung-Pin Chen, Prasad K. Kapa, William J. Houlihan
  • Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents
    Patent number: 5198459
    Abstract: The invention provides use of a 5HT-3 antagonist in the manufacture of a medicament suitable for the prevention or reduction of dependence on a dependence-inducing agent.
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: March 30, 1993
    Assignee: Sandoz Ltd.
    Inventors: Assunta Imperato, Dietmar Romer
  • Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
    Patent number: 5182271
    Abstract: The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: January 26, 1993
    Assignee: Sandoz Ltd.
    Inventor: William J. Houlihan
  • Dihydro-isoquinoline derivatives, processes for their production, pharmaceutical compositions containing them, and their use in treating asthma
    Patent number: 5177085
    Abstract: 6,7-Di(C.sub.1-4 alkoxy)-1-[3,5-di(C.sub.1-4 alkoxy)phenyl]-3,4-dihydro-3-hydroxy-methyl-isoquinolines, their physiologically hydrolyzable and -acceptable esters and acid addition salts thereof are novel. The said compounds and esters and pharmaceutically acceptable acid addition salts thereof are useful as pharmaceuticals, e.g. in the treatment of asthma.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: January 5, 1993
    Assignee: Sandoz Ltd.
    Inventor: Reto Naef
  • .alpha.-amino-.alpha.(3-alkyl-phenyl)alkyl ethanoic acids wherein the 3-alkyl moiety bears a phosphorus oxo acid group or an ester thereof, their preparation and pharmaceutical compositions containing them
    Patent number: 5162311
    Abstract: The invention discloses certain substituted .alpha.-aminoacids having the formula ##STR1## where m and n are 1 or 2, and R, R.sub.1, R.sub.2, R.sub.3 and Y have various significances, which compounds are useful in treating epilepsy, disorders associated with excess GH or LH secretion, anxiety, schizophrenia, depression, CNS degenerative disorders, cerebral hypoxic conditions and stress-related psychiatric disorders.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: November 10, 1992
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: Paul L. Herrling, Werner Muller
  • 5-Aryl-substituted-2,3-dihydro-imidazo(1,2-a)furo- and thieno pyridines
    Patent number: 5141932
    Abstract: The invention discloses certain 5-aryl-substituted-2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines useful as PAF receptor antagonists and for treating tumors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-mediated bronchoconstriction and extravasation, for controlling hyperreactive airways, for protecting against endotoxin-induced hypotension and death and for treating tumors.
    Type: Grant
    Filed: December 4, 1990
    Date of Patent: August 25, 1992
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: William J. Houlihan, Seung H. Cheon
  • Acid addition salts of amidated taurine or glycine, their preparation and use
    Patent number: 5122520
    Abstract: Acid addition salt of taurine or glycine, their amino group being amidated with a carboxylic acid residue which contains the structure of a 3.alpha., 7.alpha., 12.alpha.-trihydroxysteroid, their acid group being neutralized with the amino group of an aliphatic amine or neutralized with the amino group of a basic .alpha.-amino carboxylic acid which group is connected over an alkylene bridge with the .alpha.-amino acid group, may be used e.g. as transmucuous resorption promoter of drug compounds.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: June 16, 1992
    Assignee: Sandoz Ltd.
    Inventors: Moise Azria, Zdenek Brich
  • Use of the R-(+)-isomer of 2-methoxy-3-octadecyloxy-propanol-(1)-phosphoric acid, monocholine ester in treating multiple sclerosis
    Patent number: 5082846
    Abstract: The invention discloses the use of the R-(+)-isomer of 2-methoxy-3-octadecyloxy-propanol-(1)-phosphoric acid, monocholine ester in treating multiple sclerosis and to pharmaceutical compositions containing said isomer.
    Type: Grant
    Filed: August 30, 1990
    Date of Patent: January 21, 1992
    Assignee: Sandoz Ltd.
    Inventor: William J. Houlihan
  • Heterocyclic phospholipids useful in treating multiple sclerosis
    Patent number: 5064816
    Abstract: invention relates to heterocyclic phospholipids of formula III which are useful in treating multiple sclerosis:where R .sub.2 is n-C.sub.14 -C.sub.20 alkyl;each R.sub.1, independently, is methyl or ethyl; Y is --O-- or --S--;n is an integer 2 to 6.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: November 12, 1991
    Assignee: Sandoz Ltd.
    Inventor: William J. Houlihan
  • New use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents
    Patent number: 5039680
    Abstract: The invention provides use of a 5HT-3 antagonist in the manufacture of a medicament suitable for the prevention or reduction of dependence on a dependence-inducing agent.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: August 13, 1991
    Assignee: Sandoz Ltd.
    Inventors: Assunta Imperato, Dietmar Romer
  • Method of inducing a serotonin M receptor antagonist effect with N-quinuclidinyl-benzamides
    Patent number: 5017582
    Abstract: The dicarboxylic, heterocyclic and substituted benzoic acid alkylene bridged piperidyl amides and esters are serotonin M antagonists.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: May 21, 1991
    Assignee: Sandoz Ltd.
    Inventors: Peter Donatsch, Gunter Engel, Bruno Hugi, Brian P. Richardson, Paul A. Stadler, Gerald Breuleux, legal representative
  • Triglyceride-water emulsion pharmaceutical vehicles
    Patent number: 5010067
    Abstract: An injectable pharmaceutical mixture comprises:(A) a water-oil emulsion vehicle comprising:(a) about 5 to 25% fatty acid triglycerides;(b) sufficient physiologically acceptable emulsifying agent, e.g. from about 0 to 1.2% egg phosphatides, purified; andthe balance water, with sufficient alkali metal hydroxide added to adjust to an alkaline pH: and(B) an active ingredient which is a PAF receptor inhibitor or anti-tumor agent, which is an ether or carbamoyl phospholipid salt.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: April 23, 1991
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: Dean A. Handley, William J. Houlihan, David B. Weinstein
  • Benzoic acid derivatives
    Patent number: 5001133
    Abstract: The substituted benzoic acid heterocyclic amides and esters are serotonin M antagonists. Included are compounds of the formula Iq ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, Z' and R.sub.8 ' have various definitions.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventors: Brian P. Richardson, Gunter Engel, Rudolf K. A. Giger, Andrea Vasella
  • Alkylene oxide-containing amphoteric surfactants
    Patent number: 4992211
    Abstract: The invention relates to novel alkylene oxide-containing amphoteric compounds and to their use as surface active agents. The novel amphoteric compounds are especially useful in the cosmetics and toiletries areas, e.g., as surfactants in shampoo compositions.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Ltd.
    Inventor: Robert V. Casciani
  • 5-aryl-substituted-2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines
    Patent number: 4992428
    Abstract: The invention discloses certain 5-aryl-substituted,2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines useful as PAF receptor antagonists and for treating tumors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-mediated bronchoconstriction and extravasation, for controlling hyperreactive airways, for protecting against endotoxin-induced hypotension and death and for treating tumors.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Pharm. Corp.
    Inventors: William J. Houlihan, Seung H. Cheon
  • Process for preparing glycine hydrochloride
    Patent number: 4988789
    Abstract: An improved process for preparing glycine hydrochloride in a high purity and high yield employing water as the solvent.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: January 29, 1991
    Assignee: Sandoz Ltd.
    Inventor: Jerome Linder
  • Isoquinoline derivatives and their use
    Patent number: 4980359
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is hydrogen and R.sub.3 is hydrogen or C.sub.1-4 alkyl, or R.sub.2 and R.sub.3 together represent an additional bond as indicated by the dotted line; R.sub.4 is hydrogen, C.sub.1-4 alkyl or phenyl; R.sub.5 is methoxy or ethoxy; R.sub.6 is hydrogen, hydroxy, C.sub.1-4 alkoxy, hydroxy-(C.sub.2-4 alkoxy) or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); R.sub.7 and R.sub.8 are each independently C.sub.1-4 alkoxy or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); and R.sub.9 is hydrogen or halogen,in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular as bronchodilators, eosinophil accumulation and/or activation inhibiting agents and in the treatment of prophylactic treatment of obstructive or inflammatory airways diseases.
    Type: Grant
    Filed: April 10, 1990
    Date of Patent: December 25, 1990
    Assignee: Sandoz Ltd.
    Inventors: Klaus Hasspacher, Reto Naef
  • Ether sulfates of a mixture of branched 1-decanols
    Patent number: 4980087
    Abstract: The invention relates to novel ether sulfates based on a mixture of branched 1-decanols and to their use as surface active agents. The novel ether sulfates are especially useful as the essential surfactant component in shampoo compositions, which compositions exhibit good foaming properties with little or no irritation potential.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: December 25, 1990
    Assignee: Sandoz Ltd.
    Inventors: Anthony Latella, Robert V. Casciani
  • Carboxyalkylated derivatives of alkyl and alkenyl catechol ethoxylates and detergent compositions containing same
    Patent number: 4960536
    Abstract: The invention relates to novel carboxyalkylated derivatives of alkyl and alkenyl catechol ethoxylates and to their use as surface active agents. The novel carboxyalkylated derivatives are especially useful as self-sequestering surfactants in detergent compositions.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: October 2, 1990
    Assignee: Sandoz Ltd.
    Inventor: Robert V. Casciani
  • Uses of 4-(3-phosphono-2-propenyl)-2-pierazinecarboxylic acid
    Patent number: 4939129
    Abstract: The uses of piperazinecarboxylic acid in the treatment of disorders characterized by reduced drive and/or social withdrawal, sleep disturbances or migraine.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: July 3, 1990
    Assignee: Sandoz Ltd.
    Inventors: Arnold K. Dixon, Julian A. Gray