Patents Represented by Attorney Joseph J. Borovian

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  • Analgesic and myotonolytic preparations
    Patent number: 4442084
    Abstract: Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.
    Type: Grant
    Filed: August 11, 1982
    Date of Patent: April 10, 1984
    Assignee: Sandoz Ltd.
    Inventor: Dietmar Romer
  • Dibenzazepine derivatives, pharmaceutical compositions containing them, and pharmaceutical methods using them
    Patent number: 4434171
    Abstract: Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging agents.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: February 28, 1984
    Assignee: Sandoz Ltd.
    Inventor: Werner M/u/ ller
  • Neuroleptic use of morphanthridines
    Patent number: 4406900
    Abstract: Compounds of formula I, ##STR1## wherein R is hydrogen, alkyl (C.sub.1-4) or hydroxyalkyl (C.sub.2-3), are useful as neuroleptics, sleep promoters, myotonolytics, and anti-depressants.
    Type: Grant
    Filed: September 22, 1981
    Date of Patent: September 27, 1983
    Assignee: Sandoz Ltd.
    Inventors: Fritz Hunziker, Rudolf Fischer
  • Use of guanfacine in treating schizophrenia
    Patent number: 4404226
    Abstract: This invention provides a new neuroleptic use of a guanidine derivative and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: July 6, 1982
    Date of Patent: September 13, 1983
    Assignee: Sandoz Ltd.
    Inventors: Milan Matejcek, Carl Theohar, Horst Kleinlogel
  • Bicyclic heterocyclic amino derivatives
    Patent number: 4398028
    Abstract: The present invention concerns compounds of formula ##STR1## wherein X is O, S or NH; n is 1 or 2 and A is a 5-membered heterocyclic ring, wherein the bicyclic system may be substituted. The compounds are useful as myotonolytic and anti-hypertensive agents.
    Type: Grant
    Filed: June 24, 1981
    Date of Patent: August 9, 1983
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Guanfacine in treating opiate addiction
    Patent number: 4380550
    Abstract: This invention provides a new opiate withdrawal use of an guanidine derivative and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: May 28, 1982
    Date of Patent: April 19, 1983
    Assignee: Sandoz Ltd.
    Inventors: Horst Kleinlogel, Carl Theohar
  • Esters of 2,5-anhydro-D-mannitol
    Patent number: 4378369
    Abstract: Agents for lowering glucose levels in blood having the formula: ##STR1## wherein each R, independently, is hydrogen, C.sub.1-6 alkylcarbonyl or a group of the formula ##STR2## where R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, halo or trifluoromethyl, andR.sub.2 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or halo, with the proviso that when one R is hydrogen, the other R is not hydrogen.
    Type: Grant
    Filed: October 5, 1981
    Date of Patent: March 29, 1983
    Assignee: Sandoz, Inc.
    Inventor: Ronald Simpson
  • Sulpho group-containing anthraquinone dyestuffs
    Patent number: 4376077
    Abstract: Disclosed are anthraquinone dyestuffs which, in free acid form, are of formula I, ##STR1## in which R signifies an alkyl radical of 6 to 24 carbon atoms, an unsubstituted cyclohexyl radical or a cyclohexyl radical substituted by one or more substituents selected from halogen atoms and alkyl and alkoxy radicals,R.sub.1 and R.sub.2, independently, each signifies an alkyl radical of 1 to 6 carbon atoms,X signifies --O-- or a direct bond,ring A is unsubstituted or substituted by one or two halogen atoms, hydroxyl groups or C.sub.1-4 alkyl or alkoxy groups,their production and use in the dyeing of anionic dyeable substrates, particularly natural and synthetic polyamide fibers.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: March 8, 1983
    Assignee: Sandoz Ltd.
    Inventors: Wolfgang Schoenauer, Roland Wald
  • 4,4'-(Alkanediyl)-bis(2,2,6,6-tetraalkyl -1-oxa-4-aza-2,6-disilacyclohexanes)
    Patent number: 4374130
    Abstract: This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, andeach R is lower alkyl having 1 to 4 carbon atoms, or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents in particular glucagon inhibiting agents.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: February 15, 1983
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof
    Patent number: 4362731
    Abstract: The myotonolytic use of compounds of formula I ##STR1## wherein R is hydrogen, acetyl or a group of formula IIR'--O--CO-- IIwherein R' is alkyl(C.sub.1-8); phenyl; phenyl substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4); phenylalkyl; or phenylalkyl in which the phenyl group is substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4).
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: December 7, 1982
    Assignee: Sandoz Ltd.
    Inventor: Ronald C. Hill
  • Dibenzazepine derivatives, pharmaceutical compositions containing them, and methods of use
    Patent number: 4360525
    Abstract: Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging agents.
    Type: Grant
    Filed: September 29, 1981
    Date of Patent: November 23, 1982
    Assignee: Sandoz Ltd.
    Inventor: Werner Muller
  • 1-Phenyl-pyrazole derivatives as glucagon inhibitors
    Patent number: 4359474
    Abstract: The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are prepared by cyclization of a phenyl hydrazine compound with a 1,1,3,3-tetra-C.sub.1-4 -alkoxy-propane compound.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: November 16, 1982
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Nicholas A. Paolella
  • Benzofuran(2)one or indolin(2)one compounds useful as stabilizers for organic materials
    Patent number: 4338244
    Abstract: The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran(2)one compound or indolin(2)one compound containing at least two benzofuran(2)one or indolin(2)one nuclei.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: July 6, 1982
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider
  • Pyrazinobenzodiazepines
    Patent number: 4337198
    Abstract: either(i) X is --CH.sub.2 -- and n is 0, 1, 2 or 3 or(ii) X is --CO-- and n is 1, 2 or 3 or(iii) X is --O-- and n is 2 or 3,R.sub.2 is hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms,R.sub.3 is hydrogen, halogen, trifluoromethyl, or alkyl or alkoxy of 1 to 4 carbon atoms,R.sub.4 is hydrogen, or alkyl or alkoxy of 1 to 4 carbon atoms,andR.sub.5 is hydrogen, alkyl of 1 to 4 carbon atoms or alkenyl of 3 or 4 carbon atoms, with the proviso that, when R.sub.2 is hydrogen, R.sub.5 is hydrogen,are useful for inducing sleep and treating psychoses and depressions.
    Type: Grant
    Filed: April 24, 1980
    Date of Patent: June 29, 1982
    Assignee: Sandoz Ltd.
    Inventors: Dieter Sorg, Albert Leutwiler
  • Thiazoline and imidazoline derivatives useful as minor tranquilizers
    Patent number: 4333945
    Abstract: This invention provides a new tranquillizing use of thiazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: June 8, 1982
    Assignee: Sandoz Ltd.
    Inventor: Erwin Ringwald
  • Cationic surfactant-containing aqueous wax dispersions, and their use as textile finishing agents
    Patent number: 4329390
    Abstract: Aqueous dispersions of an oxidized microcrystalline wax, optionally together with one or more non-oxidized paraffins, in which a cationic surfactant is used as dispersing agent may be applied to textile substrates by impregnation or exhaust processes. The treated textile substrates, particularly knitted goods, have improved sewability and are less liable to damage by high-speed sewing machines.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: May 11, 1982
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Thiazoline and imidazoline derivatives useful as antidepressants
    Patent number: 4329354
    Abstract: This invention provides a new antidepressive use of thiazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: May 23, 1980
    Date of Patent: May 11, 1982
    Assignee: Sandoz Ltd.
    Inventor: Erwin Ringwald
  • Benzofuranone or indolinone compounds useful as stabilizers for organic materials
    Patent number: 4325863
    Abstract: The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran (2) one or indolin (2) one compound as stabilizer. Such stabilized polymeric materials are stabilized against degradation during the polymer processing.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: April 20, 1982
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider
  • Morphanthridine derivatives
    Patent number: 4308207
    Abstract: Compounds of formula I, ##STR1## wherein R is hydrogen, alkyl (C.sub.1-4) or hydroxyalkyl (C.sub.2-3), are useful as neuroleptics, sleep promoters, myotonolytics, and anti-depressants.
    Type: Grant
    Filed: January 11, 1980
    Date of Patent: December 29, 1981
    Assignee: Sandoz Ltd.
    Inventors: Fritz Hunziker, Rudolf Fischer
  • Aryl phosphonites and thiophosphonites useful as antioxidants
    Patent number: 4308218
    Abstract: Aryl phosphonites and thiophosphonites of the formula, ##STR1## in which the or each R, independently, is alkyl, alkoxy, chlorine or dialkylamino, there being at the most one dialkylamino group, at the 4-position and unaccompanied by any other substituents, on the benzene nucleus,n is zero, 1, 2 or 3,each X, independently, is oxygen or sulphur,and each R.sub.1, independently, is alkyl or optionally substituted phenyl,are useful as antioxidants. Organic material, e.g. polypropylene, which are susceptible to the degradative effects of oxygen, are treated with one or more of such compounds, e.g. by incorporation into the body of the organic material, in order to be stabilized against such effects.
    Type: Grant
    Filed: May 29, 1980
    Date of Patent: December 29, 1981
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Rudolf Moesch, Guenther Tscheulin