Patents Represented by Attorney Joseph J. Borovian

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  • Hydroxy-[1-substituted carbonyl-2-(or 3-) piperidinyl methoxy]phosphinyloxy]-N,N,N-trialkylalkaneaminium hydroxide inner salt oxides having antitumor activity
    Patent number: 4749696
    Abstract: The invention discloses hydroxy-[1-substituted carbonyl-2-(or 3-) piperidinyl methoxy]phosphinyloxy]-N,N,N-trilkylalkaneaminium hydroxide inner salt oxides useful as antitumor agents, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for treating tumors.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 7, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: Mark L. Lee
  • 1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents
    Patent number: 4737500
    Abstract: Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: April 12, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: Dieter Sorg
  • 4-(2,1,3-benzoxadiazol and benzothiadiazol-4-4L)-1,4-dihydropyridine-3,5-dicarboxylic acid esters useful as antihypertensives
    Patent number: 4707482
    Abstract: 1,4-Dihydropyridine-3,5-dicarboxylic acid esters of formula I ##STR1## wherein the substitutents have various significances, are useful as calcium antagonists.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: November 17, 1987
    Assignee: Sandoz Ltd.
    Inventor: Arnold Vogel
  • Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides
    Patent number: 4673672
    Abstract: The invention discloses substituted 2-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl) alkoxyphosphinyloxy]-alkanaminium hydroxide inner salt-4-oxides useful as anti-tumor agents, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for treating tumors.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: June 16, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: William J. Houlihan, Mark L. Lee
  • Diazepinoindoles useful for treating depression, schizophrenia, social withdrawal or anxiety and pharmaceutical compositions containing them
    Patent number: 4673674
    Abstract: Diazepinoindoles or pharmaceutically acceptable acid addition salts thereof are useful as antidepressant, conflict reducing or neuroleptic agents.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: June 16, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: Fulvio Gadient
  • Piperazine derivatives, their production and pharmaceutical compositions containing them
    Patent number: 4652565
    Abstract: Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: March 24, 1987
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts
    Patent number: 4619917
    Abstract: The invention discloses certain substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated bronchoconstriction and extravasation, PAF-induced hypotension and PAF-induced ischemic bowel disease.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: October 28, 1986
    Assignee: Sandoz Pharm. Corp.
    Inventors: Mark L. Lee, Christian Jaeggi
  • Pharmaceutical preparation comprising co-dergocrine and a calcium antagonist
    Patent number: 4617306
    Abstract: Pharmaceutical preparations comprising (a) co-dergocrine or a pharmaceutically acceptable acid addition salt thereof and (b) a calcium antagonist or a pharmaceutically acceptable salt thereof, as well as the treatment of hypertension/migraine by co-administration of components (a) and (b), e.g. in the form of a composition as defined.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: October 14, 1986
    Assignee: Sandoz Ltd.
    Inventors: Dieter Welzel, Hans Buhlmann
  • 2-piperazinyl-quinazoline derivatives and pharmaceutical compositions containing them
    Patent number: 4588725
    Abstract: 2-Piperazinyl-quinazolines or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic and anti-hypertensive agents.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: May 13, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Benzoxadiazoles and benzothiadiazoles
    Patent number: 4567271
    Abstract: Compounds of formula I, ##STR1## wherein X is oxygen or sulphur, and R.sub.1 -R.sub.6 are various substituents. The compounds are useful for treating coronary insufficiency, intermittent claudication, cerebrovascular insults, spasms in muscles and hypertension.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: January 28, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Piperazine derivatives and pharmaceutical composition containing them
    Patent number: 4565816
    Abstract: Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: January 21, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Pharmaceutical compositions effective against coronary heart disease and hypertension
    Patent number: 4510150
    Abstract: Pharmaceutical composition containing as active agents (A) a calcium antagonist of a 4-(2,1,3-benz-oxa- or thiadiazoly)-1,4-dihydro pyridine type and (B) a .beta.-blocker and/or a vasodilating nitrate, effective against coronary heart disease and hypertension.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: April 9, 1985
    Assignee: Sandoz Ltd.
    Inventor: Richard Berthold
  • 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydropyridazine derivatives, their production and pharmaceutical compositions
    Patent number: 4491581
    Abstract: Novel 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridazines, particularly compounds of the formula I, ##STR1## wherein COOR.sub.1 and COOR.sub.2 are the same or different carboxylic acid ester groups,R.sub.3 is H or (C.sub.1-6)alkyl andR.sub.4 is H, (C.sub.1-6)alkyl, (C.sub.3-6)alkenyl or -alkynyl, (C.sub.3-7)cycloalkyl, (C.sub.4-8)cycloalkylalkyl, (C.sub.7-9)phenylalkyl or (C.sub.9-12) phenylalkenyl, the phenyl ring being unsubstituted or mono-, di- or trisubstituted independently by halogen, OH, (C.sub.1-4)alkyl or -alkoxy,for the treatment of coronary insufficiency, spasms in smooth muscles, hypertension or cerebrovascular insufficiency.
    Type: Grant
    Filed: October 28, 1982
    Date of Patent: January 1, 1985
    Assignee: Sandoz Ltd.
    Inventor: Arnold Vogel
  • 1-Phenyl-azepinoindoles
    Patent number: 4478750
    Abstract: A 1,2,3,4,5,6-hexahydro-6-phenyl-azepino[4,5-b]indole, or a pharmaceutically acceptable acid addition salt thereof is a useful neuroleptic, anti-depressant and anti-allergic agent.
    Type: Grant
    Filed: June 7, 1982
    Date of Patent: October 23, 1984
    Assignee: Sandoz Ltd.
    Inventor: Fulvio Gadient
  • Amino-2,1,3-benzothiadiazole and -benzoxadiazole derivatives, their preparation and pharmaceutical compositions containing them
    Patent number: 4476135
    Abstract: The compounds of formula I ##STR1## wherein A is an optionally substituted 2,1,3-benzothiadiazole or 2,1,3-benzoxadiazole moiety,B is a trisubstituted amino group andC is an optionally 1-substituted 4,5-dihydro-1H-imidazol-2-yl or an optionally 3-substituted 3,4,5,6-tetrahydropyrimidin-2-yl moiety.are useful as bradycardiac agents, as anti-tremor, anti-rigor and myotonolytic agents, as tranquillizers and as antidepressants.
    Type: Grant
    Filed: February 16, 1982
    Date of Patent: October 9, 1984
    Assignee: Sandoz Ltd.
    Inventors: Peter Neumann, Gerhard Bormann
  • Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
    Patent number: 4466972
    Abstract: Compounds of formula I, ##STR1## wherein X is oxygen or sulphur, and R.sub.1 -R.sub.6 are various substituents.The compounds are useful for treating coronary insufficiency, intermittent claudication, cerebrovascular insults, spasms in muscles and hypertension.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: August 21, 1984
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Process for preparing alkoxylates containing primary amine functions
    Patent number: 4460789
    Abstract: The invention relates to a new process for preparing alkoxylates containing primary amine functions comprising reacting a monoalkanolamine or a polyamine compound with a carbonyl compound to form an amide- or carbamate-type condensation product, reacting said condensation product with an alkylene oxide compound to form an alkylene oxide adduct of said condensation product, and salifying the so-formed adduct under mild, acidic conditions.
    Type: Grant
    Filed: June 10, 1982
    Date of Patent: July 17, 1984
    Assignee: Sandoz, Inc.
    Inventor: Robert V. Casciani
  • Triazinyl compounds as intermediates for producing naphthoquinone derivatives
    Patent number: 4455424
    Abstract: The present invention relates to naphthoquinone derivatives of formula I, ##STR1## in which R.sub.1 signifies a halogen atom, a nitro group or an unsubstituted or substituted alkoxy or amino group,R.sub.2 signifies the atoms necessary to form an unsaturated ring system, which ring system has 1 or 2 nuclei and is unsubstituted or substituted,R.sub.3 signifies an unsubstituted or substituted s-triazinyl or pyrimidyl radical, andn is 0, 1 or 2,which compounds are free from sulphonic acid groups are useful as pigments or disperse dyes.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: June 19, 1984
    Assignee: Sandoz Ltd.
    Inventor: Bansi L. Kaul
  • Pyrrolobenzotriazepines
    Patent number: 4450108
    Abstract: A pyrrolobenzotriazepine or a pharmaceutically acceptable acid addition salt thereof is useful as a neuroleptic, anti-depressant or soporific.
    Type: Grant
    Filed: December 17, 1980
    Date of Patent: May 22, 1984
    Assignee: Sandoz Ltd.
    Inventors: Rudolf Fischer, Franz M. Kunzle, Jean Schmutz
  • Dihydropyridine derivatives useful in treating vascular headaches
    Patent number: 4442112
    Abstract: A pharmaceutical composition for treating or preventing vascular headaches, containing a 4-(2,1,3-benz-oxa- or thia-diazolyl)-1,4-dihydropyridine as an active compound.
    Type: Grant
    Filed: August 24, 1982
    Date of Patent: April 10, 1984
    Assignee: Sandoz Ltd.
    Inventor: Else Muller-Schweinitzer