Abstract: Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each incorporation step.
Abstract: A switch element for surface mounting onto a printed circuit board which has a bearer element (2) and a contact element (1). Both the bearer element and the contact element are formed from an electrically conductive material and the contact element being formed from a resilient material. The bearer element and the contact element can be of an integral construction or are separate components assembled together. By this construction the bearer element comprises a peripheral retainer for the contact element. In one arrangement the bearer element has an inwardly facing C-shaped cross sectional shape to provide a recess to act as a peripheral retainer for the contact element by receiving at least a portion of the rim of the contact element in the C-shaped member recess.
Abstract: A dimmer circuit arrangement is disclosed including a second control circuit for controlling the operation of a triac for delivering current to a load, and a first control circuit for controlling the operation of an IGBT power semiconductor switch for controlling the rate of rise of load voltage. The first control circuit also controls the operation of the second control circuit.
Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
Type:
Grant
Filed:
March 14, 2006
Date of Patent:
December 25, 2007
Assignee:
Renovis, Inc.
Inventors:
Michael G. Kelly, John Kincaid, Satyanarayana Janagani, Matthew Duncton
Abstract: Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
Type:
Grant
Filed:
May 4, 2005
Date of Patent:
December 25, 2007
Assignee:
Renovis, Inc.
Inventors:
Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid, David Lonergan, YunFeng Fang, Zhi-Liang Wei
Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gƒ Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
Abstract: A dimmer circuit arrangement is disclosed including a second control circuit (40) for controlling the operation of a triac (50) for delivering current to a load (60), and a first control circuit (10) for controlling the operation of an IGBT power semiconductor switch (20) for controlling the rate of rise of load voltage. The first control circuit also controls the operation of the second control circuit.