Abstract: An anti-tumor pharmaceutical composition includes cells into which a gene encoding human IL-6 has been inserted. A method of treatment of a patient suffering from cancer to prevent and/or inhibit the development of metastases by administering to the patient the anti-tumor pharmaceutical composition including the above mentioned cells.

Abstract: A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD) and the transgenic animal made by the method is disclosed. The method includes producing an F.sub.1 generation by crossing a first and second transgenic parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AD pathology. The offspring of the F.sub.1 generation are then screened and those which carry a transgene from each parental transgenic animal resulting in an enhanced pathology for Alzheimer's Disease are selected. In a preferred embodiment the AD-associated pathology is for amyloid accumulation. In an embodiment a mutant presenilin transgene and a transgene for a mutant amyloid precursor protein are used.

Abstract: The invention relates to a sustained-release pharmaceutical delivery system for the administration of an antioxidant drug to a patient in need of such drug, wherein said delivery system comprises said drug in combination with a polymeric matrix, said matrix comprising a polymer which does not interact with said drug or a mixture of such polymers. The pharmaceutical delivery system of the invention is useful for the treatment of pathological conditions involving pathologically increased formation of active oxygen species.

Abstract: A motor vehicle is provided having an elongated body with a front and rear end aligned along a longitudinal axis, a right and left seat area, and a right and left entry opening defined in part by a right and left sill member. A pair of front wheels and a pair of rear wheels are pivotally attached to the body generally adjacent the front and rear ends thereof. The front and rear wheels have a tire contact width of TW.sub.F and TW.sub.R. The front tires having a front wheel track WT.sub.F and the rear tires having a rear wheel track WT.sub.R measured from center of tire contact to center of tire contact of the tires making up a pair. The front wheel track being greater than the rear wheel track so that WT.sub.R +TW.sub.R is less than WT.sub.F. This dimensional relationship enables the sill members to be generally rearwardly inclined relative to the body longitudinal axis to facilitate easy vehicle entry by an occupant.

Abstract: A method to assess oxidative stress in vivo by measuring the amount of free, esterified and glucuronidated forms of isoprostanes (8EPGF2) in a biological sample which contains the isoprostanes is disclosed. The method further includes determining the amount of total isoprostanes present in the sample. This amount is compared with a control sample. The oxidative stress is determined through the comparison wherein the amount of isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control. Alternatively the method of the present invention provides for only the measurement of the glucuronidated form wherein the amount of glucuronidated isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control.

Abstract: The invention relates to synthetic phosphorothioated or partially phosphorothioated oligodeoxynucleotides capable of selectively modulating hemopoietic bone marrow cells development. More particularly, the invention relates to synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE or 2HS genes, having phosphorothioate bonds linking between the nucleotide bases; synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE gene, 2HS gene or BCHE gene or against a 5'-region in the human CHED (cdc2 homolog) gene, having phosphorothioate bonds linking between the four 3'-terminus nucleotide bases. The invention also relates to pharmaceutical compositions comprising as active ingredient at least one synthetic phosphorothioated or partially phosphorothioated antisense oligodeoxynucleotides according to the invention in physiologically acceptable carrier in diluent.

Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers introduce heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.

Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers have heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.

Abstract: A method for examining a visual field of a subject includes the steps of stimulating the subject eye movement reflex to an off field visual stimulus and mapping the subject visual field based on a positive reflex to the stimulus. An apparatus (20) for evaluating the visual field of a subject (22) includes a subject affixation mechanism (24) for affixing a portion of the apparatus (20) to the subject (22), an eye tracking mechanism (26) operatively connected to the subject affixation means (24) for tracking eye movement of the subject (22), and visual field stimulus generater (28) operatively connected to the affixation mechanism (24) for generating a visual stimulus.

Abstract: A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.

Abstract: A method of diagnosing and determining the disease stage of a degenerative disease of the central nervous system associated with the impairment of integrative brain function is disclosed. The method includes the steps of (a) measuring a cytokine production level of peripheral mononuclear cells from a peripheral blood sample and (b) determining the disease stage by comparing the level determined in step (a) with a level generated by age-matched normal controls.

Abstract: The torso-support garment provides increased support for larger women that is useful as an undergarment, as a bra-top for outerwear, or as the top of a two-piece swimsuit. The garment comprises an inner and an outer bra attached together. Each inner cup is attached to an outer cup and each inner backstrap is attached to an outer backstrap. The inner bra is made of a heavyweight powerknit fabric having two-way stretch properties.

Abstract: A human cataractous lens nuclei methanolic extract characterized in that it comprises substances having a molecular weight lower than 3000 daltons, inhibiting ATP hydrolysis by Na.sup.+,K.sup.+ -ATPase having affinity to the ouabain binding site on the enzyme and cross-reacting with an antibody directed against digoxin. Compounds of the general formula are disclosed: ##STR1## or of the general formula: ##STR2## in which R is hydrogen, an amino acid, a di- or tripeptide or a mono-, di- or trisaccharide. Pharmaceutical preparations and methods of using the compounds are also disclosed.

Abstract: A device for shaping a vacuum includes a housing having a primary passageway which includes an inlet. A fluid shaping mechanism is disposed in the primary passageway in fluid communication with the inlet for changing the shape of a fluid flow into a planar fluid flow flowing radially outwardly from a central point. The fluid shaping mechanism includes a conically-shaped portion disposed within the primary passageway, a plurality of secondary passageways extending through the housing from a periphery of the cone-shaped surface to outlets at a bottom surface of the housing, and a reflector adjacent to and spaced from the bottom surface for uniformly reflecting the fluid from the secondary passageways radially outwardly to create a vacuum adjacent thereto.

Abstract: A method for production of a form-specific and/or inhibitory antibody against a cytochrome P450 protein is disclosed. The method includes the steps of selecting a cytochrome P450 protein for which a form-specific and/or inhibitory antibody is needed. The amino acid sequence of the selected cytochrome P450 protein is determined and aligned with a comparison amino acid sequence using an alignment algorithm. A peptide sequence corresponding to a region of a substrate recognition site is identified and a peptide of the selected sequence prepared. Using the peptide as an immunogen, an inhibitory and/or form-specific antibody is produced.

Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.

Abstract: A spinal implant fixation assembly includes a bone fixation member, such as a screw or hook for fixation to a bone. A rod receiving seat is operatively connected to the bone fixation element for seating a portion of a rod therein. A locking mechanism, in the form of a nut and locking ring engage the rod receiving seat for forcing an inner wall of the rod receiving seat to contour around and engage the rod seated therein and for locking and fixing the rod relative to the inner housing. In one embodiment, the locking ring secures a head portion of the bone fixation element within the assembly. A method is also provided for locking the rod to a bone by fixing a rod seating member to a bone and seating a portion of a rod within a substantially U-shaped seat of the seating member. The rod is then locked within the U-shaped seating member while engaging and contouring at least a portion of the U-shaped seat about the rod.

Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia and its genomic organization is disclosed. Methods and a kit for the detection of carriers of mutations of the ATM gene are provided by analysis of nucleic acids isolated from patients including in situ hybridization, Northern blotting and reverse transcriptase--polymerase chain reaction, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification and DNA-chip analysis.

Abstract: This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F.sub.2 -like compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.