Abstract: A method for molding a composite article by injecting a plastics material resin into the fibers within a mold by a continuous web of fibers that is laid in a mold in such fashion that a honeycomb structure is produced without the web crossing itself.

Abstract: A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.

Abstract: An end fitting assembly (10) for connecting a hose to an external device is disclosed. The end fitting assembly (10) includes a stem (11) adapted to be inserted into the inner channel (32) of a hose (30). The stem (11) includes an axial bore (13) adapted to convey a fluid therethrough. The stem (11) further includes a plurality of circumferential barbs (12), each of the barbs (12) including a plurality of lands (12a, 12b) at the outer surface thereof. One of the lands (12a) is disposed at an acute angle with respect to the axis of the bore (13) of the stem (11). A second one of the lands (12b) is disposed adjacent to the first land (12a) and is disposed at a smaller acute angle with respect to the axis of the bore (13) of the stem (11) than the angle of the first land (12a). The stem (11) further includes an additional barb (15) having a rotation resisting structure provided thereon to resist relative rotational movement between the stem (11) and a hose (30) into which the stem (11) is disposed.

Abstract: A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.

Abstract: A double-hole pencil-point (DHPP) spinal needle is composed of a closed end blunt ogival or pencil point tip and two circular coaxial holes in close proximity to the tip. Anesthetic solution may be injected through the coaxial holes in a direction parallel to the long axis of the spinal fluid column which allows an even anesthetic distribution with a low dosage required. The spinal needle of the present invention allows anesthetic solution to be injected even when one of the holes is obstructed by a tissue fragment and rapid reflux of cerebral spinal fluid at twice the rate of single hole pencil point spinal needles.

Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.

Abstract: A rapid screening method for the detection and identification of target microorganisms in a sample which may contain both target microorganisms and competing non-target microorganisms includes the steps of enriching a sample in a mildly selective medium, incubating the sample in the growth medium for a predetermined amount of time, adding at least one inhibitor of the non-target microorganisms to the growth medium to discourage the growth of non-target microorganisms and to encourage the growth of target microorganisms. The method further includes the steps of incubating the sample in the growth medium including at least one inhibitor for a predetermined amount of time, performing biochemical assays specific for the identification of the target microorganisms, and detecting the presence of the target microorganisms in the sample. The invention further provides a system for the rapid detection of microorganisms in a sample.

Abstract: A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.

Abstract: A glycoprotein having a molecular weight of 28,000 to 32,000 and an isoelectric point of 7.0 to 9.0, both as determined by two-dimensional SDS polyacrylamide gel electrophoresis, is synthesized and secreted specifically by stromal cells of endometriotic origin. Amino acid residues in the region of the N-terminus of the glycoprotein share amino acid sequence identity with a region of tissue inhibitor of metalloproteinases-1 (TIMP-1). A method of screening for endometriosis is disclosed by detection of lower levels of the protein or TIMP-1 in peritoneal fluid or serum samples of women.

Abstract: A pharmaceutical composition includes an aqueous solution/suspension of omeprazole or other substituted benzimidazoles and derivatives thereof in a pharmaceutically acceptable carrier comprising a bicarbonate salt of a Group IA metal. A method for treating and/or preventing gastrointestinal conditions by administering to a patient a pharmaceutical composition including an aqueous solution/suspension of omeprazole or other substituted benzimidazoles and derivatives thereof in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal wherein the administering step consists of a single dosage form without requiring further administering of the bicarbonate salt of the Group IA metal.

Abstract: A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.

Abstract: The invention relates to a method and kit for the prediction of the response of a patient suffering from superficial bladder carcinoma to treatment with bacillus Calmette-Guerin (BCG), by calculating the inducibility of the Interleukin-2 (IL-2) gene of the patient in a sample of peripheral blood mononuclear (PBM) cells from the patient receiving BCG. The method includes the steps of culturing at least two aliquots of PBM from the patient where the cells in a first aliquot are cultured in the presence of an inducing agent for inducing expression of the IL-2 gene and the cells in the second aliquot are cultured in the absence of the inducing agent. The extent of expression of the IL-2 gene is quantitatively determined for each aliquot. The ratio of the extent of the expression of the IL-2 gene in the first aliquot to the extent of the expression of the IL-2 gene in the second aliquot is calculated, the ratio providing a measure of the inducibility of the IL-2 gene.

Abstract: A respirator apparatus comprises a mask with a passage and a mesh material disposed across the passage. The mesh material is fused between two layers of the mask material in a molding process. The mask is made of a cross-linked polyethylene material that is flexible, resilient, impervious to liquids, and a good insulator. The cross-linked polyethylene material may be formed to fit the individual facial contours of the wearer, and has a memory. A lip is disposed across the top of the mask, and provides a seal, preventing moist air from escaping that may fog the goggles or the glasses of the wearer.

Abstract: The present invention is an isolated and purified DNA sequence which encodes a vertebrate mRNA for a neuron specific protein, neuronatin. The mRNA is selectively expressed in brain tissue during rapid brain growth when there is a surge in neuronal proliferation and migration and is repressed in adult tissue. In the human, the genomic DNA is as set forth in SEQ ID No:6 and the cDNA has a nucleotide sequence as set forth in SEQ ID No:5, with the gene mapped to human chromosome 20q11.2-12. The deduced protein is a proteolipid that appears to have a role in ion channel regulation during brain development.

Abstract: A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.

Abstract: The invention relates to a plasmid carrying a selenium-specifying DNA seqce of the E. coli fdhF gene upstream of the E. coli lac'Z gene which permits the incorporation of selenocystein into .beta.-galactosidase. Particular plasmids according to the invention are pRM2, deposited at the ATCC under No. 75594 and pRM4, deposited at the ATCC under No. 75595. The invention also relates to microorganisms transformed with a plasmid according to the invention having selenium dependent .beta.-galactosidase activity. The invention provides a method for the quantitative determine of selenium in selenium derivatives in a biological sample comprising incubating microorganisms according to the invention in a suitable medium also containing said sample and measuring the level of .beta.-galactosidase activity. The biological sample may be, e.g. a blood sample or a food sample.

Abstract: A method of producing a sustained localized brain immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the brain tissue.

Abstract: An antibody to the purified and isolated glycoprotein and functional analogs thereof characterized by being progesterone induced and estradiol inhibited secretory glycoprotein specifically from stromal cells of endometrial origin. The protein has the molecular weight of 70,000 daltons as determined by two-dimensional SDS-PAGE polyacrylamide gel electrophoresis and has an isoelectric point of 5.7.

Abstract: A method for Gram staining a specimen containing bacteria includes the steps of staining Gram positive bacteria in the specimen, fixing the stain to the Gram positive bacteria, and simultaneously decolorizing and counter-staining Gram negative bacteria in the specimen.

Abstract: A purified and isolated Sertoli cell and secretory cell hybrid, or an aggregate of these two cells, wherein the secretory cells preferably are pancreatic islet cells and chromaffin cells characterized by beinga) capable of survival in situ after transplantation;b) able to provide immunoprotection for the hybrid cells when transplanted; andc) able to provide a mechanism for prolonged viability and cellular functionality of the transplanted hybrid cells wherein the hybrid maintains both the immunoprotection characteristics of the Sertoli cell and the secretory function of the secretory cell.