Patents Represented by Attorney, Agent or Law Firm Kohn & Associates
  • Double transfectants of the MHC genes as cellular vaccines for immuno prevention of tumor metastasis
    Patent number: 5750102
    Abstract: The present invention relates to anti-tumor vaccines comprising at least one type of tumor cell into each of which at least two genes encoding MHC proteins of different haplotypes have been inserted, or naturally expressed, said genes being expressed in said tumor cells and wherein at least one of said MHC proteins has the same haplotype as a haplotype of the individual to be vaccinated. The invention furthermore relates to a method of treating a patient suffering from a tumorous disease comprising administering a vaccine of the invention and to the use of a vaccine of the invention for the preparation of an anti-tumor vaccine.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: May 12, 1998
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Lea Eisenbach, Michael Feldman
  • Fusion implant
    Patent number: 5749916
    Abstract: A fusion implant for insertion between opposing vertabrae includes a body having an inner surface defining a hollow inner chamber for containing a graft material therein. The body includes a stress transfer mechanism for transferring stress from the vertabrae surrounding the implant to the graft material contained within the implant. A method is provided for implanting the fusion implant between opposing vertabraes by the steps of inserting an implant into a collapsed disc space between adjacent vertabrae, the implant including a collapsed body, and expanding the body to spread the adjacent vertabrae apart.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: May 12, 1998
    Assignee: Spinal Innovations
    Inventor: Marc Richelsoph
  • Phaseolus .alpha.-D-galactosidases
    Patent number: 5731426
    Abstract: A DNA (SEQ ID No.:2) and amino acid (SEQ ID No.:4) sequences of Glycine .alpha.-D-galactosidase are provided as well as the DNA sequence (SEQ ID No:5) and mature length amino acid sequence (SEQ ID No:7) of Phaseolus.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: March 24, 1998
    Assignee: The Curators of the University of Missouri
    Inventors: Daniel S. Smith, John C. Walker
  • Mutated proteins associated with ataxia-telangiectasia
    Patent number: 5728807
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 17, 1998
    Assignee: Ramot-University Authority For Applied Research and Industrial Development, Ltd.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis S. Collins
  • Clavulanic acid salts
    Patent number: 5726170
    Abstract: The salts are prepared by reacting a benzhydrylamine of the formula I (or a salt thereof) with clavulanic acid (or a salt thereof) in solvent, and isolating the resulting salt. In formula I, each of R.sup.1 and R.sup.2 is hydrogen (preferred) or an acceptable substituent. ##STR1## The clavulanic acid salts can be used in pharmaceutical formulations together with a pharmaceutically acceptable carrier, and, preferably, a beta-lactam antibiotic.
    Type: Grant
    Filed: February 22, 1996
    Date of Patent: March 10, 1998
    Assignee: Spurcourt Limited
    Inventor: George Leo Callewaert
  • Protective arm and wrist guard
    Patent number: 5722092
    Abstract: The present invention is a protective guard for use during sports such as snowboarding. It comprises a substantially rigid dipartite sleeve adapted to receive the distal forearm, wrist and proximal portion of a hand; thumb receiving region at one end of the sleeve to receive and partially surround the base of the thumb of a user and retaining straps to hold the sleeve on the arm of a user.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: March 3, 1998
    Inventors: Mark Borzecki, David C. Nielen
  • Method for masking the cornea
    Patent number: 5723142
    Abstract: A method of masking the cornea of an eye during surgical application of laser energy by forming an ablatable mask on the eye.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: March 3, 1998
    Inventor: Barry L. Bowyer
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 5710304
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: January 20, 1998
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Sertoli cells as neurorecovery inducing cells for Parkinson's disease
    Patent number: 5702700
    Abstract: A method of generating in situ trophic factor production by transplanting Sertoli cells into the central nervous system of a mammal, the cells creating trophic factors in situ.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: December 30, 1997
    Assignee: University of South Florida
    Inventors: Paul R. Sanberg, Don F. Cameron, Cesario V. Borlongan
  • Method of utilizing isocyanate linkage for forming multi-tier cascade polymers
    Patent number: 5703271
    Abstract: A method of synthesizing multitier cascade polymers and the polymers made thereby are formed by reacting at least one tier of a polymer with a functionalized isocyanate having the following formula:O.dbd.C.dbd.N--C(CH.sub.2 --R).sub.3with R being selected from the group including:--(CH.sub.2).sub.n --CH.sub.2 --COOR' a)with R' being selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl- polycycloalkyl, adamantyl, n=0-10;--O--(CH.sub.2).sub.n --CH.sub.2 --COOR'--O--(CH.sub.2).sub.n --CH.sub.2 --CN b)with R' being selected from the group consisting of alkyl (c-1 to C(20), cycloalkyl (C-3 to C-10), aryl heteroaryl, polycycloalkyl, adamantyl, n=0-10; and--CH.sub.2 --(CH.sub.2).sub.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: December 30, 1997
    Assignee: University of South Florida
    Inventors: George R. Newkome, Claus Weis
  • Method and compositions to assess oxidative stress in vivo
    Patent number: 5700654
    Abstract: This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F.sub.2 -like compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: December 23, 1997
    Assignee: Vanderbilt Unversity
    Inventors: L. Jackson Roberts, Jason D. Morrow
  • Method for making a medicament for treating secondary immunodeficiency
    Patent number: 5698194
    Abstract: A method of producing a natural nonrecombinant cytokine mixture is disclosed including the steps of immobilizing at least one mitogen in a tissue culture vessel. An isolated population of lymphocytes free of neutrophils and erythrocytes, is suspended in a serum-free media and placed in the vessel. The lymphocytes are cultured, the media removed, and characterized for the yield of cytokines.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: December 16, 1997
    Assignee: University of South Florida
    Inventor: John Winthrop Hadden
  • Prevention of protein aggregation
    Patent number: 5688651
    Abstract: A method of selecting anti-aggregation molecules with chaperone-like activity that have characteristics including binding to a native target molecule epitope with a high binding constant and are non-inhibitory to the biological activity of the target molecule. The method molecules denaturating a target molecule in the presence of presumptative antiaggregation molecules to prevent the target molecules from self-or induced-aggregation. The nonaggregated target molecule coupled to the anti-aggregation molecule is then tested for bioactivity.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: November 18, 1997
    Assignee: RAMOT University Authority For Applied Research and Development Ltd.
    Inventor: Beka Solomon
  • Method for regulating bone forming cells
    Patent number: 5688531
    Abstract: Regulation factors and a method for modulating bone forming cells including the steps of collecting regulation factors from bone stromal cells including marrow adipocytes and treating the bone forming cells with the regulation factors derived from stromal cells to modify the bone forming cells.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 18, 1997
    Assignee: Ramot University Authority for Applied Research and Industrial Development, Ltd.
    Inventors: Dafna Benayahu, Shlomo Wientroub
  • Circular air bag made of two simultaneously woven fabrics
    Patent number: 5685347
    Abstract: A method of forming an air bag which includes the steps of weaving on a loom an upper and lower fabric simultaneously, the two fabrics being combined in selected areas to define a seam of substantially circular shape. A bag is produced by cutting within the seam. The bag does not have an additional coating, but the permeability of the bag is determined by controlling the sett thereby utilizing the permeability of the weave itself.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: November 11, 1997
    Assignee: Airbags International Limited
    Inventors: Raymond Graham, Christopher Paul Kavanagh, Simon Valkenburg, Michael Gervase Litton
  • Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
    Patent number: 5686133
    Abstract: A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: November 11, 1997
    Assignee: Port Systems, L.L.C.
    Inventors: Gordon L. Amidon, John R. Crison
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 5684189
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: November 4, 1997
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Human papilloma virus inhibition by a hairpin ribozyme
    Patent number: 5683902
    Abstract: Synthetic catalytic RNAs, i.e. ribozyme, including a hairpin portion, binding sites for binding to a human papilloma virus after viral base 419 and 434, respectively, and cleavage sites for cleaving the virus at the binding sites have been constructed.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: November 4, 1997
    Assignees: Northern Illinois University, United States of America as represented by the Department of Health and Human Services
    Inventors: Arnold Hampel, Joseph DiPaolo, Andrew M. Siwkowski, Scott C. Galasinski
  • Method for covalently linking adjacent oligonucleotides
    Patent number: 5681943
    Abstract: A method for increasing oligonucleotide selectivity comprising reversibly binding two oligonucleotides at adjacent positions to the bases on a complementary template and then spontaneously and irreversibly covalently joining said oligomers via two reactive groups brought into proximity of each other by the binding of the oligonucleotides, in the absence of added reagent or enzyme. By using a shorter, lower affinity, highly selective first oligonucleotide complementary which binds to the site of a point mutation combined, with a longer, high affinity, less selective second oligonucleotide, this method provides an effective way to identify the presence of absence of a point mutation.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: October 28, 1997
    Assignee: Northwestern University
    Inventors: Robert Lewis Letsinger, Sergei M. Gryaznov
  • Hat
    Patent number: D387541
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: December 16, 1997
    Inventors: David B. Kellman, Marc E. Kellman