Abstract: The present invention provides a method and system for registering rules for attributes of an entity with an entity validation and inference unit. The entity validation and inference unit can further validate input values for an entity and/or infer attributes of an entity using the associated registered rules. The entity validation and inference unit can also provide information regarding attributes, relations, and behaviors of an entity using the associated registered rules in response to a query. The present invention also provides a mechanism for a user to query an entity or the entity validation and inference unit regarding valid values for an entity. The mechanism also allows the user to query the registered rule associated with the entity.

Abstract: A schema that enables a user to store data generated in an array-based computing environment in a scientific data file is disclosed. The schema may provide a mapping between the data types of the array-based computing environment and the data types of the scientific data file format. The schema may also apply when data is loaded from the scientific data file into the array-based computing environment. When the data is stored in the scientific data file, the file contains descriptions of the data as the variables of the array-based computing environment so that the data in the file can be loaded into the array-based computing environment without additional user input. The loaded variables (name and value) are identical to their state before the data is stored in the file.

Abstract: A fuel cell stack has fuel cell units. Each of the fuel cell units includes first and second membrane electrode assemblies and first to third separators sandwiching the first and second membrane electrode assemblies. A positioning mechanism is used for positioning the first to third separators in alignment with each other. The positioning mechanism includes a first protruded portion and a second protruded portion. The first protruded portion protrudes from one surface of the second separator for positioning the first separator. The second protruded portion protrudes from the other surface of the second separator for positioning the third separator.

Abstract: Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed.

Abstract: A method of saving portions of a simulation or execution engine image at various points in a simulation or execution is disclosed. The saving of the simulation or execution context in addition to the more traditional saving of the system state information enables the restoration of a simulation or execution that is capable of producing, in a subsequent simulation or execution of a block diagram continuing from the point of the saved simulation or execution, results that are identical to those of the initial simulation or execution. The ability to restore more than just system state variables enables a user to run multiple variations of a simulation from a given point without having to replicate the simulation up until the point of the saved initial simulation, and the ability to run multiple iterations of a block diagram execution in a non-simulation execution from a given point without having to replicate the execution of the block diagram up until that point.

Abstract: Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least one cytokine that regulates development of a T helper type 1 or T helper type 2 response is modulated. In one embodiment, the agent is a stimulatory form of a compound comprising a Lewis antigen, such as a Lewisy, Lewisx or Lewisa oligosaccharide, or a derivative thereof. In another embodiment, the agent is an inhibitory form of a compound comprising a Lewis antigen, such as a Lewisy, Lewisx or Lewisa oligosaccharide, or a derivative thereof. In various embodiments, the immune cell is a human immune cell, a macrophage or a T cell. Pharmaceutical compositions for modulating immune responses are also provided.

Abstract: A water-jacket structure, for a water-cooled internal combustion engine, forms a cylinder block water jacket in a cylinder block so as to surround cylinder bores formed in the cylinder block to make cooling water flow through the cylinder block water jacket into a cylinder head water jacket formed in a cylinder head joined to the cylinder block. An upper connecting opening is formed in an upper part of the cylinder block water jacket so as to open into the cylinder head water jacket. In the cylinder block is formed a lower connecting passage opening into a lower part of the cylinder block water jacket, extending upward, and connecting to the cylinder head water jacket.

Abstract: Cooled air introduced from an evaporator through a first passage in a housing is divided into laminar flows by a guide structure disposed on an air mixing door. The direction of flow of the cooled air is changed upwardly by guide walls of the guide structure and is further changed upwardly by first walls of the guide structure, after which the cooled air is introduced into a mixer. Heated air introduced from a heater core through a third passage is mixed with the cooled air in the mixer. The mixed air is delivered from a face discharge outlet, a defroster discharge outlet, or a foot discharge outlet into a passenger compartment.

Abstract: The present invention is directed toward automatically integrating a late bound program language into an external environment. The external environment may be an early bound environment, a late bound environment or some combination thereof. Associated with the late bound program environment is a modular execution engine and an interface mechanism, wherein the interface mechanism is capable of expressing late bound semantics in a format compatible with the external environment.

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

Abstract: The present invention provides systems and methods for providing two or more parameterization functions which are associated with a single graphical language environment. Such an arrangement allows for modeling of complex models with interaction across multiple domains. In the present invention, the graphical language environment include components, represented by nodes, that have multiple parameterization functions associated with them, yet operate within a single graphical language environment. A change in one parameterization function associated with one or more nodes is propagated across all associated nodes within the domain.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, chroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed 2Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recongnize this protein, and methods for diagnosing such conditions.

Abstract: The invention detects quickly and with high precision abnormalities in fuel cells. In a method of detecting abnormalities in a fuel cell 1 comprising a plurality of unit cells that generate power by supplying hydrogen gas to an anode and supplying air to a cathode of each unit cell, the abnormality in the fuel cell 1 is detected based on the speed of the decrease in the cell voltages after stopping the fuel cell, i.e., after stopping the supply of the reacting gases to the fuel cell.

Abstract: The invention provides a catalyst for catalytically reducing nitrogen oxides in diesel engine exhaust gas by use of unburnt carbon contained in the diesel engine exhaust gas as a reducing agent, the catalyst comprising: (a) an acid zeolite, or (b) an alkali metal- and/or alkaline earth metal-containing zeolite, or (c) a rare earth metal-containing zeolite, or (d) a zeolite containing at least one transition metal selected from Fe, Co, Ni and Cu.

Abstract: Provided is an apparatus for matching Gigabit Ethernet (GbE) signals to an Optical Transport Hierarchy (OTH). The apparatus real-time records a source address and input port information of GbE Ethernet frames in a memory, compares a destination address of the Ethernet frame which is a payload of a GFP frame with memory table information, searches an output port location of the GbE, and interreceives GbE frames and Generic Frame Procedure (GFP) frames by multiplexing/demultiplexing.

Abstract: Graphical programming or modeling environments in which a coding standard can be applied to graphical programs or models are disclosed. The present invention provides mechanisms for applying the coding standard to graphical programs/models in the graphical programming/modeling environments. The mechanisms may detect violations of the coding standard in the graphical model and report such violations to the users. The mechanisms may automatically correct the graphical model to remove the violations from the graphical model. The mechanisms may also automatically avoid the violations in the simulation and/or code generation of the graphical model.

Abstract: A gene relating to the regeneration ability of plants was successfully isolated and identified using linkage analysis. Furthermore, methods for breeding highly regenerative varieties, methods for transforming unculturable varieties, and methods for selecting transformed cells, wherein these methods utilize this gene, were also discovered. The present invention is useful in fields such as cultivar improvement and gene analysis that uses transformation methods.

Abstract: A control system for an internal combustion engine, which is capable of properly setting fuel injection timing according to the actual degree of delay of the amount of fresh air to be supplied to cylinders of the engine, thereby making it possible to positively suppress torque variation, when the control system has switched an air-fuel ratio mode between a lean mode and a rich mode. The control system controls the air-fuel ratio of a mixture by switching the air-fuel ratio mode. In the lean mode, the control system sets a target fresh air amount for the lean mode, and in the rich mode, it sets a target fresh air amount for the rich mode. Upon switching the air-fuel ratio mode, the control system corrects the fuel injection timing according to the difference between the target fresh air amount for the lean mode or the rich mode and the detected fresh air amount.

Abstract: A unit cell of a fuel cell includes a membrane electrode assembly and an anode side metal separator and a cathode side metal separator sandwiching the membrane electrode assembly. A plurality of first supply holes and a plurality of second supply holes extend through a channel unit of the anode side metal separator, and the channel unit connects a fuel gas supply passage and a fuel gas flow field. A fuel gas from the fuel gas supply passage flows into the first supply holes, and flows through an inlet connection channel. The fuel gas flows into the second supply holes connected to an end of the inlet connection channel. The fuel gas flows toward the side of the membrane electrode assembly, and then, the fuel gas is supplied to an anode.

Abstract: Methods for treating lymphomas characterized by expression of CD30 using anti-CD30 antibodies and proteasome inhibitors in combination are disclosed.