Patents Represented by Attorney, Agent or Law Firm Lawrence T. Welch
  • Patent number: 6194445
    Abstract: The present invention provides the use of pramipexole in the treatment of restless legs syndrome.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: February 27, 2001
    Assignees: Pharmacia & Upjohn Company, Boehringer Ingelheim Pharma KG
    Inventors: Wolfgang H. Oertel, Dieter Meier, Baltazar Gomez-Mancilla, Jacques Montplaisir
  • Patent number: 6156777
    Abstract: The present invention provides the use of pramipexole as a neuroprotective agent.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: December 5, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Edward Dallas Hall, Philip F. Von Voigtlander, Frank A. Rohde
  • Patent number: 6005105
    Abstract: The present invention is directed to a process for preparing the following compound ##STR1## which is prepared starting from ##STR2## which is reacted succesively with 4-iodobenzyl or 4-bromobenzyl bromide, hydrazine and 1,4-dimethyl-1,3-cyclohexadiene, reduced and reacted with phenyltetrazole or suitably protected phenyltetrazole followed by removal
    Type: Grant
    Filed: December 6, 1995
    Date of Patent: December 21, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Hiroyoshi Yamada, Kiyotaka Munesada, Keiko Koh, Kazuo Tsuzuki, Mikio Taniguchi, Yoshiji Fujita
  • Patent number: 5929101
    Abstract: The present invention provides a method for treatin hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: July 27, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • Patent number: 5852195
    Abstract: The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl?b!pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R.sub.10 and R.sub.20 taken together are formulae (III) and (IV).
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: December 22, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Karen Rene Romines, Gordon L. Bundy, Theresa M. Schwartz, Ruben A. Tommasi, Joseph W. Strohbach, Steven Ronald Turner, Suvit Thaisrivongs, Paul Adrian Aristoff, Paul D. Johnson, Harvey Irving Skulnick, Louis L. Skaletzky, David John Anderson, Joel Morris, Ronald B. Gammill, George P. Luke
  • Patent number: 5814670
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: September 29, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • Patent number: 5719188
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: February 17, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • Patent number: 5703071
    Abstract: The present invention provides novel tropolone derivatives of the formula I ##STR1## wherein R.sub.10 is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharamaceutical compositions thereof. These compounds are useful for the prevention and treatment of ischemic diseases, including cerebrovascular diseases and cardiovascular diseases.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: December 30, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Noriie Itoh, Mineo Kunihara, Hiroshi Kushida, William W. McWhorter, Syunji Nomura, Kazunori Ozawa, Mikio Taniguchi, Kazuo Tsuzuki
  • Patent number: 5668286
    Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel oxazolidinone derivatives represented by chemical formula (I), or pharmaceutically acceptable salts thereof, as well as antimicrobial compositions containing said derivatives or salts thereof as active ingredients.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: September 16, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Hiroyoshi Yamada, Kiyotaka Munesada, Mikio Taniguchi
  • Patent number: 5650420
    Abstract: The present invention provides the use of pramipexole as a neuroprotective agent.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: July 22, 1997
    Assignees: Pharmacia & Upjohn Company, Boehringer Ingelheim International GmbH
    Inventors: Edward D. Hall, Philip F. Von Voigtlander, Frank A. Rohde
  • Patent number: 5599841
    Abstract: The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: February 4, 1997
    Assignee: The Upjohn Company
    Inventor: Martin D. Meglasson
  • Patent number: 5594144
    Abstract: The present invention provides novel tropolone derivatives of the formula I ##STR1## wherein R.sub.10 is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharamaceutical compositions thereof. These compounds are useful for the prevention and treatment of ischemic diseases, including cerebrovascular diseases and cardiovascular diseases.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: January 14, 1997
    Assignee: The Upjohn Company
    Inventors: Noriie Itoh, Mineo Kunihara, Hiroshi Kushida, William W. McWhorter, Syunji Nomura, Kazunori Ozawa, Mikio Taniguchi, Kazuo Tsuzuki
  • Patent number: 5506361
    Abstract: There are provided pharmacologically active compounds which are highly effective to treat hypertension or congestive heart failure, and are well absorbed into the body and have long-lasting action. Thus, the present invention providesA compound represented by the general formula: ##STR1## or a pharmacologically acceptable ester or salt thereof, and a pharmaceutical composition for preventing or treating hypertension or congestive heart failure which comprises the compound as an active ingredient.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: April 9, 1996
    Assignee: TheUpjohn Company
    Inventors: Keiko Koh, Hiroshi Kushida, Noriie Itoh, Kazunori Ozawa, William W. McWhorter, Jr.
  • Patent number: 5442062
    Abstract: The present invention provides a novel imidazole derivative having the chemical formula ##STR1## These compounds are useful for preventing or treating hypertension or congestive heart failure and have high activity, rapid action upon intravenous injection, good oral absorbtion, low toxicity, and long-lasting action. Also provided are pharmaceutical compositions which contain these compounds.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: August 15, 1995
    Assignee: The Upjohn Company
    Inventors: Keiko Koh, Mikio Taniguchi, Noriie Itoh, Hiroshi Kushida, Osamu Morita, Hiroyoshi Yamada, Kiyotaka Munesada, Kazuo Tsuzuki, Mineo Kunihara, Yoshiji Fujita
  • Patent number: 5441971
    Abstract: A thiazolidinedione compound of the formula ##STR1## wherein X,Q are as defined in the specification. The compounds are used for treating diabetes.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: August 15, 1995
    Assignees: The Upjohn Company, Takeda Chemical Industries, Ltd.
    Inventors: Takashi Sohda, Hitoshi Ikeda, John C. Greenfield, Jerry R. Colca, Edgar N. Petzold
  • Patent number: 5356913
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: October 18, 1994
    Assignee: The Upjohn Company
    Inventor: Jerry R. Colca
  • Patent number: 5275934
    Abstract: Provided are methods for determining whether a vaccinated animal is uninfected or infected with a virulent wild-type virus. Methods, vaccines and viruses are disclosed that are useful to seratologically distinguish infected from uninfected animals in populations of animals vaccinated with a properly incapacitated virus lacking an antigen of the wild-type virus.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: January 4, 1994
    Assignee: The Upjohn Company
    Inventors: Leonard E. Post, Darrell R. Thomsen
  • Patent number: 5225189
    Abstract: The present invention provides a novel pharmaceutically acceptable gel containing minoxidil for topical application.
    Type: Grant
    Filed: August 17, 1990
    Date of Patent: July 6, 1993
    Assignee: The Upjohn Company
    Inventor: Lorraine E. Pena
  • Patent number: 5175298
    Abstract: The present invention provides processes and intermediates for one preparation of the hydroxy ethylene isostere dipeptide of leu-val which is itself useful in the preparation of renin inhibitory peptides. The process employs certain novel oxazolidenes.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: December 29, 1992
    Assignee: The Upjohn Company
    Inventor: Peter G. M. Wuts
  • Patent number: 5134164
    Abstract: The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: July 28, 1992
    Assignee: The Upjohn Company
    Inventor: Martin D. Meglasson