Patents Represented by Attorney, Agent or Law Firm Lawrence T. Welch
  • Pyridyl-substituted benzothiophenes
    Patent number: 4611059
    Abstract: The present invention provides novel pyridinyl-benzothiophenes and derivatives thereof which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: September 9, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Phospholipase A.sub.2 inhibition using 4,1-benzoxazepine-2-(3H)-ones
    Patent number: 4590187
    Abstract: The present invention provides certain novel 4,1-benzoxazepin-2(3H)-ones which are useful as inhibitors of phospholipase A.sub.2 and thus as inhibitors of arachidonate mobilization. These compounds are thus useful whenever it is medically necessary or desirable to inhibit the biosynthesis of the products of the arachidonic acid cascade.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: May 20, 1986
    Assignee: The Upjohn Company
    Inventors: Donald P. Wallach, deceased, Donald E. Ayer, Jacob Szmuszkovicz
  • Pyrrolizidine-3-ones
    Patent number: 4581462
    Abstract: The present invention provides certain 2,3-didehydro-5-oxopyrrolizidinones and indolizidinones which are useful as lipid-altering and anti-atherosclerotic agents.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: April 8, 1986
    Assignee: The Upjohn Company
    Inventors: Ernest W. Yankee, Ronald H. Rynbrandt, deceased
  • Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents
    Patent number: 4577020
    Abstract: The present invention provides certain aminoalkyl and aminoalkenyl triazoles which are useful as anti-psychotics. Certain of these aminoalkyl triazoles were previously known as anti-allergy agents.
    Type: Grant
    Filed: January 25, 1983
    Date of Patent: March 18, 1986
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
    Patent number: 4575554
    Abstract: The present invention provides novel substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles with gastric acid inhibiting effects.
    Type: Grant
    Filed: September 6, 1984
    Date of Patent: March 11, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Composition of matter and process
    Patent number: 4548814
    Abstract: Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting a neoplastic disease.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: October 22, 1985
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Kenneth L. Rinehart, Jr.
  • Organic compounds and process
    Patent number: 4549030
    Abstract: The present invention provides a novel process for preparing known prostaglandins, particularly 9-deoxo-9-methylene-16,16-dimethyl-PGE.sub.2. This well known and useful prostaglandin is prepared from D-glucose through a series of efficient reactions. Also provided are novel intermediates which are useful for preparation of a wide variety of prostaglandins.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: October 22, 1985
    Assignee: The Upjohn Company
    Inventor: Bruce A. Pearlman
  • 1-(6-Hydroxy-4- or -7-methoxy-5-Benzofuranyl)-4-substituted-1,3-butanediones
    Patent number: 4546177
    Abstract: The present invention provides novel 1-(6-hydroxy-4- or 7-methoxy or 4,7-dimethoxy-5-benzofuranyl)-4-substituted-1,3-butanediones which are useful as intermediates in the synthesis of khellin and related anti-atherosclerotic furochromones.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: October 8, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • 4-Hydroxy-furochromone intermediates for antiathersclerotic compounds
    Patent number: 4542228
    Abstract: The present specification provides intermediates for novel analogs of khellin, a natural product, which are useful in the treatment and prevention of atherosclerosis. Particularly, the present disclosure provides novel 5H-furo[3,2-g]-benzopyran-5-ones substituted at the nine position by methoxy and substituted at the four position by hydroxy.
    Type: Grant
    Filed: January 3, 1984
    Date of Patent: September 17, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Antiatherosclerotic aminoethenyl furochromones
    Patent number: 4540798
    Abstract: The present invention provides certain novel aminoethanyl furochromones which are useful for antiatherosclerotic purposes.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: September 10, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Derivatives of leukotrienes A and C
    Patent number: 4537723
    Abstract: The present invention provides novel derivatives of leukotrienes A and C which are useful in inhibiting the smooth muscle contracting effects of SRS-A; inhibiting platelet aggregation; and inhibiting the biosynthesis of thromboxane A.sub.2.
    Type: Grant
    Filed: October 24, 1983
    Date of Patent: August 27, 1985
    Assignee: The Upjohn Company
    Inventor: William P. Schneider
  • Intermediates for the production of prostaglandins from D-glucose
    Patent number: 4535173
    Abstract: The present invention provides a novel process for preparing known prostaglandins, particularly 9-deoxo-9-methylene-16,16-dimethyl-PGE.sub.2. This well known and useful prostaglandin is prepared from D-glucose through a series of efficient reactions. Also provided are novel intermediates which are useful for preparation of a wide variety of prostaglandins.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: August 13, 1985
    Assignee: The Upjohn Company
    Inventor: Bruce A. Pearlman
  • Furochromone intermediates
    Patent number: 4532340
    Abstract: The present invention provides novel intermediates used for preparation of anti-atherosclerotic furochromones.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: July 30, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Use of phenyl hydrazines for seed biostimulation or the treatment of lipoxygenase mediated seed deteriorations
    Patent number: 4531963
    Abstract: The present invention provides a method of treating certain deleterious conditions mediated by the action of lipoxygenases in mammals and seeds using certain phenyl hydrazines. Also provided is a method for seed biostimulation using these phenyl hydrazines.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: July 30, 1985
    Assignee: The Upjohn Company
    Inventor: Donald P. Wallach
  • Paulomycin derivatives
    Patent number: 4520191
    Abstract: Novel and useful compounds are obtained by the degradation of antibiotics paulomycin A and paulomycin B. These novel compounds are useful as ultraviolet light filters in plastics, cloth, and the like.
    Type: Grant
    Filed: November 8, 1983
    Date of Patent: May 28, 1985
    Assignee: The Upjohn Company
    Inventor: Paul F. Wiley
  • Antibiotic 273.sub.a1
    Patent number: 4505895
    Abstract: Novel and useful antibiotics designated 273a.sub.1.spsb..alpha. and 273a.sub.1.spsb..beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.
    Type: Grant
    Filed: March 30, 1983
    Date of Patent: March 19, 1985
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, Vincent P. Marshall, Paul F. Wiley
  • Pyridyl benzenediols
    Patent number: 4501892
    Abstract: The present invention provides novel benzenediols and benzedioxins which selectively inhibit thromboxane A.sub.2 synthetase and as such represent useful and potent pharmacological agents.
    Type: Grant
    Filed: July 28, 1982
    Date of Patent: February 26, 1985
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Inhibition of bacterial toxin release by prostaglandins
    Patent number: 4496587
    Abstract: The present invention provides a method for inhibiting the synthesis and release of toxins from bacteria which comprises contacting the bacteria with an antitoxic prostaglandin.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: January 29, 1985
    Assignee: The Upjohn Company
    Inventors: Harold E. Renis, Mary J. Ruwart
  • Pyridyl-substituted-benzofurans
    Patent number: 4495357
    Abstract: The present invention provides novel pyridinyl-benzofurans and derivatives thereof which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: January 22, 1985
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Didemnins A, B, C, and derivatives thereof, as antiviral agents
    Patent number: 4493796
    Abstract: Novel antibiotics didemnins A, B, C, D, and E (didemnins), are obtained from a marine organism. These antibiotics, and derivatives thereof, are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses.
    Type: Grant
    Filed: March 13, 1984
    Date of Patent: January 15, 1985
    Assignee: Board of Trustees, Univ. of Ill.
    Inventor: Kenneth L. Rinehart, Jr.