Patents Represented by Attorney, Agent or Law Firm Lawrence T. Welch
  • Anti-atherosclerotic 6,7-dihydro-7,7-disubstituted-khellin analogs
    Patent number: 4434295
    Abstract: The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5- ones.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: February 28, 1984
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Stabilization of PGI.sub.2 compounds with surfactants
    Patent number: 4430340
    Abstract: The present invention provides novel methods for the stabilization of aqueous solutions of prostacyclin and related prostacyclin analogs comprising the addition of neutral or cationic surfactants to such aqueous solutions. Additionally, the novel surfactant-containing solutions of prostacyclin and related compounds are described. Finally there are provided novel pharmaceutical compositions comprising surfactant-containing aqueous solutions of prostacyclin and related compounds.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: February 7, 1984
    Assignee: The Upjohn Company
    Inventor: Moo J. Cho
  • Pyridinyl substituted benzimidazoles and quinoxalines
    Patent number: 4430502
    Abstract: The present invention provides novel pyridinyl-benzimidazoles and quinoxalines which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: August 13, 1982
    Date of Patent: February 7, 1984
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Gastric cytoprotection with heterocyclic sulfonamides
    Patent number: 4424227
    Abstract: The present invention provides a method for gastrointestinal cytoprotection using a class of heterocyclic sulfonamides.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Andre Robert
  • Substituted piperazinyl-1,2,4-triazoles
    Patent number: 4408049
    Abstract: The present invention provides certain substituted-piperazinyl-1,2,4-triazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.
    Type: Grant
    Filed: March 26, 1982
    Date of Patent: October 4, 1983
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • Piperazinyl-substituted imidazoles
    Patent number: 4404382
    Abstract: The present invention provides certain piperazinyl-substituted imidazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.
    Type: Grant
    Filed: March 26, 1982
    Date of Patent: September 13, 1983
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • Aminoalkyl-substituted imidazoles
    Patent number: 4404387
    Abstract: The present invention provides certain substituted-piperazinyl-1,2,4-triazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.
    Type: Grant
    Filed: March 26, 1982
    Date of Patent: September 13, 1983
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • (11R)-11-Deoxy-11-alkyl-6-oxo-prostaglandins
    Patent number: 4403100
    Abstract: The present invention provides novel (11R)-11-deoxy-11-alkyl-6-oxo-prostaglandins which are useful for curing and preventing duodenal ulcers and for preventing or treating gastrointestinal cell damage caused by the use of other pharmacological agents.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: September 6, 1983
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-PG compounds
    Patent number: 4398025
    Abstract: The present invention provides novel 2-decarboxy-2-hydroxymethyl-19,20-didehydro-13,14-dihydro-PG.sub.1 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: January 7, 1982
    Date of Patent: August 9, 1983
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Method for preventing renal papillary necrosis with prostaglandins
    Patent number: 4397865
    Abstract: The present invention provides a method for the prevention of renal papillary necrosis induced by non-steroidal anti-inflammatory compounds (NOSAC) comprising the administration of certain prostaglandins.
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: August 9, 1983
    Assignee: The Upjohn Company
    Inventors: Andre Robert, George A. Elliott
  • Diuretic 2,6-diaryl-4-pyridine carboxylic acids
    Patent number: 4377586
    Abstract: The present invention provides a novel method of inducing diuresis by administering certain 2,6-diaryl-4-pyridinecarboxylic acid derivatives. Also provided are novel compounds and pharmaceutical compositions to be used in this method.
    Type: Grant
    Filed: April 30, 1981
    Date of Patent: March 22, 1983
    Assignee: The Upjohn Company
    Inventor: Louis L. Skaletzky
  • Liver cytoprotection using PGE's
    Patent number: 4374856
    Abstract: The present invention provides a method for treatment of hepatic diseases which comprises administering a hepatocytoprotective prostaglandin to a mammal who suffers from or is particularly succeptible to said hepatic diseases.
    Type: Grant
    Filed: September 10, 1980
    Date of Patent: February 22, 1983
    Assignee: The Upjohn Company
    Inventor: Mary J. Ruwart
  • 2-Decarboxy-2-tetrazolyl-6-keto-PGE.sub.1 compounds
    Patent number: 4366313
    Abstract: Prostaglandin E (PGE)-type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: December 28, 1982
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid
    Patent number: 4352760
    Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: October 5, 1982
    Assignee: The Upjohn Company
    Inventor: Kirk M. Maxey
  • 9-Deoxy-9-methylene-6-keto-PGE-type compounds
    Patent number: 4349690
    Abstract: The present invention provides novel 9-deoxy-9-methylene-6-keto-PGE derivatives which are useful for platelet aggregation inhibition and gastric cyctoprotection.
    Type: Grant
    Filed: April 23, 1981
    Date of Patent: September 14, 1982
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Aminoalkyl-1,2,4-triazoles
    Patent number: 4338453
    Abstract: Novel aminoalkyl triazoles are provided which are useful for the treatment of sensitized humans and animals for allergies and anaphylactic reactions. Additionally, a number of the compounds are useful in the treatment of hypertension. These compounds are of the formula ##STR1## wherein R.sub.4 is hydrogen, alkyl, alkoxy, aryl, sulfonyl, or sulfinyl, R.sub.5 is aryl, R.sub.6 is hydrogen, hydroxy, alkyl, alkoxy, or alkanoyloxy, and R.sub.1 is piperidinyl or amino.
    Type: Grant
    Filed: September 17, 1980
    Date of Patent: July 6, 1982
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • 2-Decarboxy-2-tetrazolyl-PG.sub.2 compounds
    Patent number: 4336372
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-PG.sub.2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4336393
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.2 compounds
    Patent number: 4336371
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.2 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-PG.sub.1 compounds
    Patent number: 4336392
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih