Abstract: A method, computer readable medium, and system for generating a unified virtual snapshot in accordance with embodiments of the present invention includes invoking with a file virtualization system a capture of a plurality of physical snapshots. Each of the physical snapshots comprises content at a given point in time in one of the plurality of data storage systems. A unified virtual snapshot is generated with the file virtualization system based on the captured plurality of the physical snapshots.

Abstract: The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete, nonconcentric, metal-containing cores. Methods of making and using these nanoparticles are also disclosed.

Abstract: The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a carbohydrate; or a steroid, e.g., cholesterol, which is optionally substituted with at least one carbohydrate. is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.

Abstract: A nanofocusing system includes a dielectric waveguide having two opposing ends; and a metal-dielectric-metal layered waveguide having two opposing ends optically aligned at one end with one end of the dielectric waveguide, wherein the metal-dielectric-metal waveguide tapers in at least one dimension from the aligned end of the metal-dielectric-metal waveguide towards the opposing end, wherein light travelling through the dielectric waveguide is funneled into the dielectric layer of the metal-dielectric-metal waveguide, squeezed by the metal-dielectric-metal waveguide taper, and exits the metal-dielectric-metal waveguide as nanofocused light.

Abstract: A method, computer readable medium, and device for providing authenticated domain name service includes forwarding at a traffic management device a request for a domain name from a client device to one or more servers coupled to the traffic management device. The traffic management device receives a first response comprising at least a portion of the domain name from the one or more servers. The traffic management device attaches a first signature to the first response when the first response is determined by the traffic management device to be an unauthenticated response, and provides the first response with the first signature to the client device.

Abstract: A method, computer readable medium, and a system for communicating with networked clients and servers through a network device is disclosed. A first network data packet is received at a first port of a network device. The first network data packet is destined for a first executing application of a plurality of executing applications operating in the network device. The plurality of executing applications are associated with corresponding application drivers utilizing independent and unique direct memory access (DMA) channels. A first DMA channel is identified, wherein the first DMA channel is mapped to the first port and associated with a first application driver corresponding to the first executing application. The first network data packet is transmitted to the first executing application over the first identified DMA channel.

Abstract: A memory system for ingress processing is arranged to access multiple banks in a time interleaved fashion. Each memory bank has an associated memory bank manager, which is arranged to track the contents and egress ports associated with data stored in the memory bank. Incoming data from ingress traffic is evaluated and segregated based on criteria. One of the memory banks is identified based on the criteria, and the incoming data is stored in the identified memory bank in the next available write cycle timeslot. Data constructs in the memory bank manager are updated to indicate the location and egress port associated with the stored data. The memory bank managers submit egress transmit bids to a master scheduler, which controls access to the memory banks. The memory banks are readout in interleaved fashion such that the effective average traffic arrival rate is increased and memory bandwidth requirements are reduced.

Abstract: Disclosed are methods for the prevention or treatment of tuberculosis in a subject infected with Mycobacterium tuberculosis by administering rhodanine derivatives of formula (I), as well as some novel such compounds. Other embodiments are also disclosed.

Abstract: The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.

Abstract: A device for lifting and moving shelves, in particular shelves for cages for laboratory animals, said device comprising: means for lifting at least one shelf, and for keeping it lifted from the ground; moving means to allow displacement of the device in the presence of a shelf lifted from the ground, along at least one direction. Structure comprising several devices as described above, engaged with a driving system to allow translation along a common direction.

Abstract: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

Abstract: The invention provides an apparatus and methods for removing heavy metals and heavy metal-containing compounds from fluid streams. The invention also provides new uses and methods for removing heavy metals and heavy metal-containing compounds from a natural gas stream, or a gas stream produced during the combustion or gasification of a fossil fuel, such as coal or petroleum fuels or oil.

Abstract: A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum.

Abstract: A method and system for generating one or more keys includes obtaining at two or more devices data based on movement of at least one of the devices with the respect to the other device. At least one key is generated based on the obtained data at each of the devices for use in securing communications between the devices. The key at each of the devices is substantially the same.

Abstract: A method, computer readable medium and apparatus that optimizes a web content proxy server includes obtaining at a proxy server a web page with an original server cookie from one of one or more web content servers in response to a request from one of one or more client devices. A web optimized client cookie based on the original server cookie is generated at the proxy server. The obtained web page with the generated web optimized client cookie is providing by the proxy server to the requesting one of one or more client devices.

Abstract: A dispensing apparatus includes a housing defining a channel, a plunger slidably engaged with an inner surface of the channel, a substrate with one or more passages each having two or more openings, a liquid in each of the one or more passages, at least one fluid, and a force application system. The substrate is disposed in the channel on one side of the plunger. The liquid in each of the one or more passages has a volume which exceeds an internal volume of each the one or more passages and forms a liquid drop around each of the openings. The liquid drops are fluidly connected to one another and each of the liquid drops is individually adjustable between two or more sizes. Each of the sizes and a location of each of the liquid drops define one of two or more switch positions. The fluid is located in the channel on the one side of the plunger and substantially surrounding the liquid drops.