Patents Represented by Attorney LeClairRyan
  • Patent number: 8309324
    Abstract: The present invention relates to an inducible and a high expression nucleic acid promoter isolated from Clostridium thermocellum. These promoters are useful for directing expression of a protein or polypeptide encoded by a nucleic acid molecule operably associated with the nucleic acid promoters. The present invention also relates to nucleic acid constructs including the C. thermocellum promoters, and expression vectors and hosts containing such nucleic acid constructs. The present invention also relates to protein isolated from Clostridium thermocellum, including a repressor protein. The present invention also provides methods of using the isolated promoters and proteins from Clostridium thermocellum, including methods for directing inducible in vitro and in vivo expression of a protein or polypeptide in a host, and methods of producing ethanol from a cellulosic biomass.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: November 13, 2012
    Assignee: University of Rochester
    Inventors: J. H. David Wu, Michael Newcomb
  • Patent number: 8306038
    Abstract: A method, computer readable medium, and system for enhancing TCP communications includes transmitting a payload fragment for each of one or more of packets. A determination of which of the one or more packets to complete and reorder is made and a sequence in a completion fragment for one or more of the packets is adjusted based on the determination. One or more of the completion fragments are transmitted based on the determining to reassemble one or more of the transmitted payload fragments with one or more of the transmitted completion fragments based on the determination and adjustment.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: November 6, 2012
    Assignee: F5 Networks, Inc.
    Inventor: Saxon Amdahl
  • Patent number: 8306036
    Abstract: Methods and systems for efficient allocation of resources between child nodes of a parent node in a hierarchical system. The parent node has a limited number of resources available in a resource allocation phrase. The limited number of resources are allocated according to requests from the child nodes in the resource allocation phase. It is determined whether at least one of the child nodes has a request not met by the allocated resources. A bookmark associated with the child node is set for the additional required resources. Additional resources are allocated to the child node according to the bookmark in a subsequent resource allocation phase.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: November 6, 2012
    Assignee: F5 Networks, Inc.
    Inventor: Benn Bollay
  • Patent number: 8304246
    Abstract: The present invention is directed to a method for differentially diagnosing dementia or the risk of dementia in a patient. The method comprises obtaining a sample from the patient; analyzing the sample to obtain quantifying data for one or more than one metabolite marker; comparing the quantifying data for the one or more than one metabolite marker to corresponding data obtained from one or more than one reference sample; and using the comparison to differentially diagnose dementia or the risk of dementia. The method may also assist in assessing dementia or the risk of dementia in a patient. The present invention is also directed to metabolite markers and compounds useful in the present method.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: November 6, 2012
    Assignee: Phenomenome Discoveries, Inc.
    Inventors: Lisa Cook, Dayan Burke Goodenowe
  • Patent number: 8304960
    Abstract: A method, computer readable medium, and a system for reducing power consumption of an at least partially resonant actuator system includes adjusting a driving system with an actuator controller computing device configured to provide a driving signal including a delay interval during a transition in the driving signal. The driving system provides the driving signal with the delay interval to an at least one partially resonant actuator device.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: November 6, 2012
    Assignees: New Scale Technologies, Austriamicrosystems AG
    Inventors: Stefan Sattler, Thomas Guidarelli
  • Patent number: 8306253
    Abstract: A modular headset and method of use comprises a headset band having a first end and a second end. The headset includes a first node coupled to the first end of the headset band in which the first node has a plurality of first jacks. Each first jack selectively receives a first plug of a peripheral device. The headset includes a second node coupled to the second end of the headset band. The second node has a plurality of second jacks. Each second jack selectively receives a second plug of the peripheral device. The headset includes circuitry coupled to the jacks at the first and second nodes, wherein signals from a peripheral device are received or transmitted to any of the first jacks in the first node and signals from the external electronic device are received or transmitted to any of the second jacks in the second node.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: November 6, 2012
    Assignee: UME Voice, Inc.
    Inventors: Paul Devlas, Adithya M. R. Padala, Joe Tate
  • Patent number: 8301837
    Abstract: A method, computer readable medium, and system for generating a response includes determining from which of a plurality of levels of cache to retrieve a response. The determination is based on a number of matches between current user session data associated with a current request and stored user session data rewritten into each of one or more metadata data variables for the response when a current request for the response matches at least one prior stored request for the response. The response from the determined level of the plurality of levels of cache is provided.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: October 30, 2012
    Assignee: F5 Networks, Inc.
    Inventor: Ravi Natarajan
  • Patent number: 8297908
    Abstract: The present invention concerns an automated system for handling trays for containing animals in a lab animal room, and particularly for inverting the trays when they emerge from the tunnel washer. One object of the present invention is thus a completely automated system comprising an inverter device associated with a system for moving the trays on rotating rollers and complete with stopper means capable of blocking the trays in their forward feed movement synchronized, by means of a central control unit, with the movements of an inverter device capable of managing trays of different shapes and sizes.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: October 30, 2012
    Assignee: IWT S.R.L.
    Inventors: Luciano Savoia, Roberto Tosi, Michele Vitali
  • Patent number: 8299733
    Abstract: A method, computer readable medium, and system for controlling velocity of an at least partially resonant actuator system in accordance with embodiments of the present invention includes determining with an actuator controller computing device a sequence of full bridge and half bridge outputs to control an output velocity of an at least partially resonant actuator device. The actuator controller computing device controls a driver system to output a driving signal based on the determined sequence of full bridge and half bridge outputs. The driver system provides the driving signal to the at least one at least partially resonant actuator device.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 30, 2012
    Assignees: New Scale Technologies, Inc., Austriamicrosystems AG
    Inventors: Stefan Sattler, Thomas Guidarelli
  • Patent number: 8292090
    Abstract: The present invention provides for a method of producing an integral multilayered porous membrane by simultaneously co-casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a porous membrane. The support can be a temporary support or form an integrated support for the membrane. The plurality of layers may be of the same polymer or different, same concentration or viscosity or different and may be subjected to the same processing conditions or different ones to form unique structures.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: October 23, 2012
    Assignee: EMD Millipore Corporation
    Inventor: Willem Kools
  • Patent number: 8292091
    Abstract: The present invention provides for a method of producing an integral multilayered porous membrane by simultaneously co-casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a porous membrane. The support can be a temporary support or form an integrated support for the membrane. The plurality of layers may be of the same polymer or different, same concentration or viscosity or different and may be subjected to the same processing conditions or different ones to form unique structures.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: October 23, 2012
    Assignee: EMD Millipore Corporation
    Inventor: Willem Kools
  • Patent number: 8288521
    Abstract: The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: October 16, 2012
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, Monib Zirvi
  • Patent number: 8285514
    Abstract: A method, computer readable medium and system for detecting a sensor fault includes identifying one or more of a plurality of tools to use with at least one of a plurality of data acquisition systems based on data obtained from and at least one characteristic of the at least one of the data acquisition systems. The identified one or more tools are utilized on the obtained data to determine at least one confidence rating. An operational status for the at least one of the data acquisition systems is determined and provided based on at least the one determined confidence rating.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: October 9, 2012
    Assignee: Rochester Institute of Technology
    Inventors: Omar Anbari, Michael G. Thurston
  • Patent number: 8283891
    Abstract: A method and system for assessing health of a power source includes measuring voltage and current of a power source in a system using a device in the system as the load. An internal resistance of the power source is determined based on the measured voltage and current. A health assessment of the power source is determined and provided based at least on the determined internal resistance and a stored baseline internal resistance for the power source.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: October 9, 2012
    Assignee: Rochester Institute of Technology
    Inventor: Omar Anbari
  • Patent number: 8283121
    Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: October 9, 2012
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
  • Patent number: 8278301
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: October 2, 2012
    Assignee: Albany Molecular Research, Inc.
    Inventors: David D. Manning, Zhicai Yang
  • Patent number: 8277058
    Abstract: Optical structures and sheeting that include polyurea and method for forming same are proposed in accordance with aspects of the present invention. One and two-component layers can be used to form the optical structures. The optical structures can include microstructures formed from polyurea. The sheeting can include at least one of cube-corner prisms, open-faced cube-corner prisms, linear prisms, lenticular lenses, moth-eye structures, lenses, Fresnel lens arrays, lenses, and fish-eye lens arrays.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: October 2, 2012
    Assignee: Reflexite Corporation
    Inventors: Dzu D. Luong, Patrick W. Mullen
  • Patent number: 8279541
    Abstract: A lens actuator module includes a lens assembly with an optical centerline and a clear aperture, a bearing guide integrated adjacent to the clear aperture with the centerline of motion substantially parallel to the optical centerline, a linear actuator with a preloaded frictional contact point that moves the lens along the centerline. The preload force is perpendicular to the optical centerline, constant and generated in-line with the contact point such that the preload force produces substantially zero additional friction in the bearing guide irrespective of the location along the optical centerline.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: October 2, 2012
    Assignee: New Scale Technologies
    Inventors: David A. Henderson, Todd Haran, Matt Wrona, Qin Xu, Daniele Piazza
  • Patent number: 8277052
    Abstract: A multimedia presentation system includes a plurality of display systems and at least one control system. The plurality of display systems output image areas of a multimedia presentation to at least partially different locations of a display environment. The control system adjusts the output of the image areas from the plurality of display systems to conform to the display environment. The display and capture systems may be wearable, mobile or adjustable and can react to any environment. Editing environments allow the same show to be easily relinked to a new display configuration without any need for extensive user-driven layout revision. Virtual display configurations are simulated and presented on other displays.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: October 2, 2012
    Assignee: Rochester Institute of Technology
    Inventors: Ian Gatley, Mitchell Rosen, James Meyer, Robert A. Clark, Jonathan Schull, Samuel Gatley
  • Patent number: D669786
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: October 30, 2012
    Assignee: Central Garden & Pet Company
    Inventors: Jeff McMillian, Fred Vogelgesang, Chuck Yeager