Patents Represented by Attorney LeClairRyan
  • Patent number: 8273575
    Abstract: Methods for the diagnosis, risk assessment, and monitoring of Autism Spectrum Disorder (ASD) are disclosed. More specifically the present invention relates to the measurement of small molecules (metabolites) in human plasma that are found to have different abundances between persons with a clinical manifestation of ASD and subjects not expressing symptoms of ASD. Further, this invention relates to the monitoring of putative therapeutic strategies designed to ameliorate the biochemical abnormalities associated with ASD.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: September 25, 2012
    Assignee: Phenomenome Discoveries Inc.
    Inventor: Dayan Goodenowe
  • Patent number: 8273770
    Abstract: 5-pyridinone substituted indazoles of the formula and methods of their use are presented.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: September 25, 2012
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter Guzzo, Matthew David Surman, Alan John Henderson, Mark Hadden
  • Patent number: 8273712
    Abstract: A method of promoting healing of a wound in a patient, the method comprising administering to the patient (i) a prostaglandin E (PGE) or an agonist thereof and/or an agent that increases the local concentration or effect of PGE and (ii) granulocyte-macrophage colony stimulating factor (GMCSF) or a derivative thereof. Use of (i) a PGE or an agonist thereof and/or an agent that increases the local concentration or effect of PGE and (ii) GMCSF or a derivative thereof in the preparation of a medicament for promoting healing of a wound in a patient. A wound dressing, bandage or fibrin glue comprising (i) a PGE or an agonist thereof and/or an agent that increases the local concentration or effect of PGE and (ii) GMCSF or a derivative thereof.
    Type: Grant
    Filed: November 24, 2006
    Date of Patent: September 25, 2012
    Assignee: Medical Research Council
    Inventor: Rodney Kelly
  • Patent number: 8268868
    Abstract: Various 5-substituted 1-substituted indazoles are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: September 18, 2012
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter Robert Guzzo, Matthew David Surman, Alan John Henderson, Mark Hadden, May Xiaowu Jiang
  • Patent number: 8263402
    Abstract: The present invention is directed to a method of separating oligodendrocyte cells or progenitor cells thereof from a mixed population of cells. It comprises selecting a promoter which functions only in the oligodendrocyte cells or progenitor cells thereof, introducing a nucleic acid molecule encoding a fluorescent protein under control of that promoter into the mixed population cells, allowing the oligodendrocyte cells or progenitor cells thereof to express the fluorescent protein, and separating the fluorescent cells from the mixed population cells, where the separated cells are the oligodendrocyte cells or progenitor cells thereof. The invention also relates to the isolated and enriched human oligodendrocyte cells or progenitor cells thereof.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: September 11, 2012
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Steven A. Goldman, Su Wang
  • Patent number: 8263356
    Abstract: The present invention relates to antibodies, binding portions thereof, or probes that bind specifically to glucosyltransferase enzymes, and uses of these agents for detecting glucosyltransferase enzyme(s) in a sample and for diagnosing predisposition of a human child to early childhood caries. The present invention also relates to a kit for detecting a glucosyltransferase enzyme in an oral sample from an animal.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 11, 2012
    Assignee: University of Rochester
    Inventors: William H. Bowen, Anne Vacca Smith, Robert Berkowitz
  • Patent number: 8260924
    Abstract: A method, computer readable medium and system for user load balancing includes identifying when an overall load in at least one of two or more servers exceeds one or more thresholds that are related to one or more user loads. One or more of the user loads in the identified overall load in one of the servers are transferred to one or more of the other servers when the one or more thresholds is exceeded.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: September 4, 2012
    Assignee: BlueTie, Inc.
    Inventor: David A. Koretz
  • Patent number: 8254665
    Abstract: Methods and systems for three-dimensional imaging include sampling one or more emissions which are reflected back from a target scene with one or more micro-channel plates. The one or more sampled emissions are processed in one or more frames. Within each frame a phase is extracted and a distance to the target scene and amplitude is determined on a pixel-by-pixel basis. A three dimensional image of the target scene is generated and provided based on the extracted phase and the determined distance and amplitude for the one or more frames.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: August 28, 2012
    Assignee: Munro Design & Technologies, LLC
    Inventor: James F. Munro
  • Patent number: 8248071
    Abstract: The present invention relates to a method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by the use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts. The present invention also relates to methods of conducting an N-dimensional NMR experiment in a phase-sensitive manner by the use of dual forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure secondary phase shifts or at least partially cancel dispersive and quadrature image signal components arising in the frequency domain from secondary phase shifts.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: August 21, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Thomas Szyperski, Arindam Ghosh, Yibing Wu
  • Patent number: 8235556
    Abstract: A condensing element, array, and methods thereof include a bowl-shaped outer section and a lens-shaped inner section. The outer section provides substantially total internal reflection of light entering at an input surface of the outer section. The inner section is recessed within the outer section at a distance from the entering light that is within the focal position of the inner section. The outer and inner sections are configured in a preferred embodiment so that substantially all the light exiting the condensing element is substantially parallel to the optical axis of the entering light. In an alternate embodiment, the configuration of the condensing element can be modified to selectively adjust the desired degree of collimation of the exiting light.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: August 7, 2012
    Assignee: Reflexite Corporation
    Inventors: James F. Munro, Penny J. Munro
  • Patent number: 8236796
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle o
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: August 7, 2012
    Assignees: Albany Molecular Research, Inc., Bristol-Myers Squibb Company
    Inventors: Bruce F. Molino, Shuang Liu, Peter R. Guzzo, James P. Beck
  • Patent number: 8239354
    Abstract: In an aggregated file system, a method of processing a user file retrieves user file metadata and user data from a metadata server and applies operations to the user data in accordance with a file open request from a client. At the end of the process, the method stores the processed user data at a location in accordance with a predefined rule and updates the metadata in the metadata server to reference the processed user data at the location. In some embodiments, the predefined rule is to choose a location between the metadata server and a separate storage server in accordance with the size of the processed user data. If the size is still smaller than a predetermined threshold, the user data is stored in the metadata server. Otherwise, the user data is stored in the storage server.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: August 7, 2012
    Assignee: F5 Networks, Inc.
    Inventors: Francesco Lacapra, Srinivas Duvvuri
  • Patent number: 8236985
    Abstract: There is provided a compound of formula (I) wherein R1a, R2a, R3, X1 to X6, a, b and c have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, inhibitors of HDAC enzyme activity, and thus, in particular, in the treatment of conditions where inhibition of HDAC enzyme activity is required.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: August 7, 2012
    Assignee: Imperial Innovations Ltd.
    Inventors: Eric Ofori Aboagye, David Michael Vigushin, Wendy Vigushin, legal representative
  • Patent number: 8234203
    Abstract: An e-commerce system offering retail, instant buy, and auction sales models automatically moves items for sale between the sales models according to seller-defined criteria, such as elasticity of demand, cash generation, time in sales model, and quantity in sales model. The retail sales model includes a virtual storefront creation tool with which sellers can create and customize their own virtual storefronts. The system lists items offered for sale in the retail and instant buy sales models by sellers with virtual storefronts in the sellers' storefronts.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 31, 2012
    Assignee: Adventive, Inc.
    Inventor: David A. Koretz
  • Patent number: 8232228
    Abstract: The present invention is directed to increasing the efficacy of agricultural chemicals. This can be achieved by applying at least one agricultural chemical to a plant or plant seed under conditions effective for the agricultural chemical to perform its intended function and applying at least one hypersensitive response elicitor protein or polypeptide to the plant or plant seed under conditions effective to increase the efficacy of the agricultural chemical. Alternatively, the present invention relates to a method for increasing the efficacy of agricultural chemicals by applying an agricultural chemical to a transgenic plants or transgenic seeds transformed with nucleic acid molecule which encodes a hypersensitive response elicitor protein or polypeptide, wherein the agricultural chemical is applied under conditions effective for the agricultural chemical to perform its intended function but with increased efficacy.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: July 31, 2012
    Assignee: Plant Health Care, Inc.
    Inventor: Zhong-Min Wei
  • Patent number: 8226262
    Abstract: A TIRing condensing element and methods thereof includes a first section and a second section. The first section provides substantially total internal reflection of light entering at a base of the first section. The second section tapers from a first section towards an optical axis of the element extending through the second section to output light from the first section. The first and second sections are configured so a half-power angle of the light output from the second section is less than the half-power angle of the light entering the first section.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 24, 2012
    Assignee: Reflexite Corporation
    Inventors: James F. Munro, Penny J. Munro
  • Patent number: 8227486
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle opt
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: July 24, 2012
    Assignees: Albany Molecular Research, Inc., Bristol-Myers Squibb Company
    Inventors: Bruce F. Molino, Shuang Liu, Peter R. Guzzo, James P. Beck
  • Patent number: 8217553
    Abstract: A linear motor system includes an element with a threaded passage, a threaded shaft, and a driving system. The threaded shaft has an axis of rotation which extends through and is at least partially engaged with at least a portion of the threaded passage. The driving system comprises at least two members operatively connected to the element. Each of the two members comprises two or more piezoelectric layers and electrodes which are coupled to opposing surfaces of each of the piezoelectric layers. The members are configured to expand and contract in a direction along the axis of rotation. The driving system is configured to subject the element to vibrations causing the threaded shaft to simultaneously rotate and translate in the direction along the axis of rotation through the element and apply an axial force in the direction along the axis of rotation.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: July 10, 2012
    Assignee: New Scale Technologies
    Inventors: Qin Xu, David Henderson, Daniele Piazza
  • Patent number: 8219357
    Abstract: A method and system for displaying asset health information includes determining a status of at least one asset in a monitored system based on operational information obtained about the at least one asset. The obtained operational information about the at least one asset is compared against other operational information obtained about the monitored system. A review of the determined status of the at least one asset is conducted based on the comparison. At least one of textual information and numeric information is displayed based on the conducted review of the determined status of the at least one asset. Additionally, at least one of three or more indicator lights is displayed based on the conducted review of the determined status of the at least one asset.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: July 10, 2012
    Assignee: Rochester Institute of Technology
    Inventors: Christopher Piggott, Edward McCarthy, Michael G. Thurston, Sean McConky
  • Patent number: 8210177
    Abstract: A valve for controlling the level of liquid within a chamber (10) is disclosed. The valve comprises a liquid inlet (30) and a primary float (40) that is movable in response to a change in the level of liquid (20) within the chamber (10) between an open configuration in which liquid (20) is able to flow through the liquid inlet (30) into the chamber (10) when the liquid (20) within the chamber (10) is below a predetermined acceptable level, and a closed configuration in which liquid (20) is prevented from flowing through the liquid inlet (30) into the chamber (10) when the liquid within the chamber (10) is at or above the predetermined acceptable level.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: July 3, 2012
    Assignee: Intersurgical AG
    Inventors: Simon Robert Payne, Keethan Fernando