Abstract: A new method of preparing 3.alpha.,5.alpha.-cyclo-6.beta.-alkoxy-.DELTA..sup.22 -25-oxy or acyloxy bisnorcholestane and analogues which involves reacting a bisnorcholanaldehyde with an ylide. Novel cholestanes and i-ethers are also claimed.

Abstract: Compounds represented below ##SPC1##And pharmaceutical compositions thereof, the compositions including the non-substituted phenylene dioxamates are useful in the prophylactic treatment of sensitized mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.

Abstract: This invention relates to pharmaceutical compositions containing known compounds of the formula ##SPC1##Wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methylammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms.The compounds (1) above are formulated with pharmaceutical carriers for inhalation or for oral, parenteral or rectal administration, with insufflation being the preferred method. The compositions are useful in the prophylactic treatment of sensitized humans and mammals for allergic and all anaphylactic reactions of a reaginmediated and non-reagin-mediated nature.

Abstract: Novel phenyl dioxamic free radicals are useful in the prophylactic treatment of sensitized humans and animals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature.

Abstract: It has now been discovered, that compounds of FIG. 1 ##SPC1##are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, the compounds are intermediates to the biologically active dioxamic acids and their salts. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.

Abstract: A new method for preparing cytosine arabinoside involving the cyanovinylation of the aminooxazoline of D-arabinose by cis-.beta.-[trimethylammonium]-acrylonitrile tosylate. Also included are new preparations of the aminooxazoline of D-arabinose and the anion of cis-1-cyano-2-hydroxyethylene.DESCRIPTION OF THE PRIOR ARTCytosine arabinoside, an anti-leukemic agent also known as 1-.beta.-D-arabinofuranosylcytosine, is a known anti-leukemic agent. Consequently, an economical and safe synthesis of the compound and other significant cytosine nucleosides is an important contribution to the well being of the populace. The Orgel and Sanchez patent, U.S. Pat. No. 3,658,788, provided a new way of preparing cytosine nucleosides, particularly cytosine arabinoside. The process consisted of preparing an aminooxazoline intermediate which is then cyanovinylated to a cyclocytidine salt. The cyclocytidine salt is then treated with aqueous ammonia to form the cytosine nucleoside.

Abstract: Compounds of the structure ##SPC1##Wherein R and R.sub.1 are the same or different and are selected from the group consisting of hydrogen, halogen, and alkyl from one to four carbon atoms, inclusive, and R.sub.2 is a substance which inhibits thrombogenic or clotting activity of a material and is that portion of a substituted aromatic which couples with a diazonium salt.

Abstract: It has now been discovered that novel compounds of FIG. 1 ##SPC1##are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, these compounds are intermediates to the acids and physiologically acceptable salts which also have the same biological utility. The compounds of the invention are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.

Abstract: A method for preparing the 5,7- steroid diene illustrated below, and intermediates thereof, has been discovered.

Abstract: Compounds of the formula below are compounded into pharmaceutical compositions and are useful for treatment of arrhythmic conditions.

Abstract: Novel compounds of formula 1 ##SPC1##And ##SPC2##Are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.

Abstract: A new method for converting certain diesters to physiologically acceptable amines which comprises reacting the diester with the desired amine in a solvent consisting essentially of water.

Abstract: The pharmaceutical compositions and methods of using these compositions for anti-arrhythmic and diuretic uses are disclosed for the compounds below: ##EQU1##

Abstract: Novel chemical compounds of the formula: ##SPC1##WhereinR is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, phenyl, alkali metal, or an amine cation;X and Y can be the same or different and are selected from the group consisting of hydrogen, alkyl of from one to six carbon atoms, inclusive, cycloalkyl of 5 or 6 carbon atoms, inclusive, phenyl, hydroxyl, alkoxy having from one to three carbon atoms, inclusive, halogen, trifluoromethyl, cyano, carboxyamide and O C-OQ, ##EQU1## where Q is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, alkali metal, and an amine cation, with the proviso that whereR is hydrogen, alkali metal or an amine cation, then Q is the same as R, and whereR is phenyl or alkyl from one to three carbon atoms, then Q is phenyl or alkyl from one to three carbon atoms; andZ is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and phenyl.

Abstract: A method for preparing 25-hydroxycholesterol and novel intermediates.

Abstract: In accordance with this invention, there are disclosed compounds of the formula ##SPC1##Wherein X is selected from the group consisting of nitro and amino with the proviso that when y is hydrogen, X is nitro; Y is selected from the group consisting of hydrogen and fluoro; R is selected from the group consisting of hydrogen and alkyl of from one to six carbon atoms, inclusive.These compounds are compounded into pharmaceutical compositions and administered to mammals for purposes of relieving inflammation and to mammals in need of prophylactic anti-thrombotic treatment.

Abstract: A new process for coating materials which are susceptible to interaction with an aromatic sulfonyl nitrene which involves contacting an aromatic sulfonylazide with said material and irradiating.

Abstract: Compounds represented below ##SPC1##And pharmaceutical compositions thereof are useful in the prophylactic treatment of mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.

Abstract: Compounds of the formula ##SPC1##Are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.Compositions of these compounds formulated with pharmaceutical carriers and methods of using these compositions are also provided.