Patents Represented by Attorney Martin F. Savitzky

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  • Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B.sub.4 antagonist activity, their preparation and use in pharmaceutical compositions
    Patent number: 5366982
    Abstract: This invention relates to compounds having selective LTB.sub.4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB.sub.4 agonist-mediated activity utilizing said compositions wherein the compounds are described by the general formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: November 22, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Norbert Dereu, Wolfram Hendel, Richard Labaudiniere
  • Compounds having antihypertensive and anti-ischemic properties
    Patent number: 5364862
    Abstract: This invention relates to adenosine derivatives and analogs which possess adenosine agonist activity and are useful as anti-hypertensive and anti-ischemic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypertension and myocardial ischemia, and to methods and intermediates used in the preparation of such compounds.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: November 15, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Alfred P. Spada, Cynthia A. Fink, Michael R. Myers
  • Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid
    Patent number: 5347039
    Abstract: This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one with a borohydride in the presence of titanium derivative.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: September 13, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Patrick Leon, Xavier Radisson, Viviane Massonneau
  • Thioformamide derivatives
    Patent number: 5342848
    Abstract: Thioformamide derivatives of formula (I): ##STR1## wherein R represents alkyl; A represents optionally substituted pyrid-4-yl; Y represents ethylene or methylene or a direct bond and X represents an optionally substituted phenyl, pyridyl, furyl or thienyl group or optionally substituted alkyl, alkenyl or cycloalkyl, and salts thereof possessing useful pharmacological properties.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: August 30, 1994
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Terance W. Hart, Bernard Y. J. Vacher
  • Compounds having cholecystokinin and gastrin antagonistic properties
    Patent number: 5340801
    Abstract: This invention relates to N-arylcarbamoyl proline analogues which are useful as cholecystokinin and gastrin antagonists, to pharmaceutical compositions including such proline analogues, and to their use in preventing or treating cholecystokinin or gastrin related disorders.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: August 23, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: William R. Ewing, Bruce F. Molino
  • Antithrombotic peptides and pseudopeptides
    Patent number: 5332726
    Abstract: This invention relates to novel peptide and pseudopeptide derivatives and analogs of aspartic acid which are useful as inhibitors of platelet aggregation and thrombus formation in mammalian blood, to pharmaceutical compositions including such compounds, and to their use in inhibiting thrombus formation and platelet aggregation in mammals.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: July 26, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino, Mark Czekaj, Charles Gardner, Michael R. Becker, Jeffrey M. Dener, Jeffrey C. Pelletier
  • Anti-thrombotic peptide and pseudopeptide derivatives
    Patent number: 5328900
    Abstract: Disclosed are novel peptide and pseudopeptide derivatives and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: July 12, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Azacyclic bisphosphonates as anticholesterolemic agents
    Patent number: 5317015
    Abstract: This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: May 31, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John W. Ullrich, Raymond D. Youssefyeh, Daniel L. Cheney, Christopher J. Burns
  • Pyran derivatives
    Patent number: 5304660
    Abstract: The invention provides compounds of formula (I) wherein R.sup.1 represents alkyl, R.sup.2 represents an acid-labile protecting group and X.sup.1 represents a halogen atom, which are useful in the synthesis of mevalonic acid derivatives.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: April 19, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Stanley F. Clark, Ronald H. Jones, Christopher G. Newton
  • Methods for the inactivation of viruses in viral-contaminated pharmaceutical compositions
    Patent number: 5300433
    Abstract: The present invention provides a fail-safe combination of chemical and physical means for rendering a blood product which comprises a labile blood protein free of viruses without incurring protein denaturation. The blood product is contacted with an effective amount of a selected chemical disinfectant, preferably, sodium thiocyanate in combination with a physical process, preferably, ultrafiltration. The blood product may be plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant containing viruses such as hepatitis or human immunodeficiency virus.
    Type: Grant
    Filed: September 25, 1991
    Date of Patent: April 5, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Michael E. Hrinda, Rose D'Alisa, George C. Tarr
  • 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides
    Patent number: 5288731
    Abstract: Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT.sub.3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D.sub.2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT.sub.3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: February 22, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John E. Airey, Matthew R. Powers, Walter Rodriguez, Raymond D. Youssefyeh
  • Process for preparing chiral dibenzofurans via intramolecular heck reaction
    Patent number: 5278323
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by an intramolecular Heck stereospecific synthesis substantially free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 11, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers
  • Hydrazine derivatives
    Patent number: 5276046
    Abstract: A hydrazine derivative of formula (I), ##STR1## wherein A represents an optionally substituted phenyl, naphthyl or heteroaromatic group containing one or two nitrogen atoms, and R.sup.1 represents hydrogen, optionally substituted alkyl, or optionally substituted benzyl, phenethyl, or 1-naphthylmethyl, or pyrid-3-ylmethyl group, and salts thereof, possess useful pharmaceutical properties.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: January 4, 1994
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Terance W. Hart, Brian W. Sharp, Roger J. A. Walsh
  • Pure glia maturation factor
    Patent number: 5270452
    Abstract: Pure homogeneous glia maturation factor is disclosed with methods for producing it from neutral sources and by molecular cloning and genetic engineering.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: December 14, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Ramon Lim, Ruth Kaplan, Michael Jaye
  • Antithrombotic diaminoalkanoic acid derivatives
    Patent number: 5258398
    Abstract: This invention relates to novel diaminoalkanoic acid derivatives that inhibit platelet aggregation and thrombus formation in mammalian blood thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease and disseminated intravascular coagulation, to pharmaceutical compositions including such compounds, and to their use in inhibiting thrombus formation and platelet aggregation in mammals.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: November 2, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors
    Patent number: 5258544
    Abstract: Disclosed is a process for the preparation of 2-aryl-1-cyclohexene-1-carboxaldehydes from 1-arylcyclohexenes which are intermediates for trans-6-[(2-arylsubstituted cycloalkenyl and substituted cycloalkyl)alkenyl and alkyl]-3,4,5,6-tetrahydro-2H-pyran-2-ones.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: November 2, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Laurence W. Reilly, Jr., Ching T. Tsuei, Walter Rodriquez, Thomas Goetzen
  • Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydro-pyran-2-ones
    Patent number: 5248830
    Abstract: Disclosed are intermediates and a process of making an anticholesterolemic compound of the formula ##STR1## the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: September 28, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John Ullrich, John R. Regan
  • 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them
    Patent number: 5240948
    Abstract: Compounds of formula: ##STR1## in which R.sub.1 represents a polyfluoroalkoxy radical and R.sub.2 represents an alkylthio, alkylsulphinyl or alkylsulphonyl radical, their salts, their preparation and the medicaments containing them.
    Type: Grant
    Filed: January 29, 1991
    Date of Patent: August 31, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Claude Gueremy, Patrick Jimonet
  • Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
    Patent number: 5238919
    Abstract: This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from synthetic peptide mixtures or isolated from lysates of organisms capable of producing recombinant human vWF. The fragments and sub-fragments are useful in the prevention and treatment of cardiovascular disorders by virtue of their ability to inhibit the binding of vWF to platelets, heparin and/or collagen.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: August 24, 1993
    Assignee: Scipps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Yoshihiro Fujimura, Richard A. Houghten, Zaverio M. Ruggeri
  • Process for preparing dibenzofurans via catalytic heteroannulation
    Patent number: H1406
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by a stereospecific catalytic heteroannulation synthesis free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 3, 1995
    Assignee: Rhone Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers