Patents Represented by Attorney Martin F. Savitzky

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  • Sustained production of recombinant gamma interferon using an Epstein-Barr virus replicon
    Patent number: 4939088
    Abstract: A recombinant DNA expression vector comprising an Epstein-Barr virus origin of replication, an EBNA-1 gene, a selectable marker expression cassette and a human gamma interferon expression cassette comprising a promoter region, an open reading frame encoding human gamma interferon and a polyadenylation region; a mammalian host cell transformed by said vector; and a process for producing human gamma interferon using said transformed mammalian host cell.
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: July 3, 1990
    Assignee: Meloy Laboratories Inc.
    Inventors: Janet M. Young, Nava Sarver, William N. Drohan
  • Benzoxepins as intermediates to 5HT.sub.3 antagonists
    Patent number: 4924010
    Abstract: Certain specific substituted 9-N-(1-azabicycolo-[2.2.2.]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-ben zoxepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic activity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: May 8, 1990
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Raymond Youssefyeh, Scott I. Klein, Henry F. Campbell, Donald E. Kuhla
  • Pyridazinone and pyrazolone compounds, cardiotonic compositions including same, and their uses
    Patent number: 4906629
    Abstract: This invention relates to substituted pyridooxazinone and naphtheridone pyridazinone and pyrazolone compounds which are useful as cardiotonic agents for the treatment of congestive heart failure, to methods for increasing cardiac contractility using said compounds, and pharmaceutical compositions including the same.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: March 6, 1990
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Alfred P. Spada, William L. Studt, Henry F. Campbell, Donald E. Kuhla, Thomas Tucker
  • Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
    Patent number: 4906630
    Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: March 6, 1990
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, William C. Faith, Bruce F. Molino
  • Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4818755
    Abstract: Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: April 4, 1989
    Assignee: Rorer Pharmaceutical Corporaton
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Bruce F. Molino
  • 3- and 5-(bicyclic ether or bicyclic alkylene thioether) alkylene amino thiatriazines
    Patent number: 4816583
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: March 28, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson, Robert A. Galemmo, Jr., Pamela J. Durham
  • Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
    Patent number: 4806535
    Abstract: This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of the formula ##STR1## wherein A is CH or N and not more than one of W, X, Y and Z is a N atom which possess valuable pharmaceutical preparations, e.g., increasing cardiotonic contractility. Uses of said compounds including methods for increasing cardiac contractility and in the treatment of congestive heart failure, pharmaceutical compositions including the same and methods for the preparation thereof.
    Type: Grant
    Filed: July 22, 1987
    Date of Patent: February 21, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William C. Faith, Henry F. Campbell, Donald E. Kuhla, William L. Studt, James L. Barnes
  • Coating compositions and method for improving the properties of coated substrates
    Patent number: 4791008
    Abstract: An acidic aqueous coating composition comprising dissolved phosphate, dissolved aluminum, dissolved dichromate, inorganic colloidal particles and a water miscible organic component including an effective film-forming amount of a water miscible material comprising an ether of a polypropylene glycol, and preferably including also another glycol material, for example, a mono-ethylene glycol material or a mono-propylene glycol material, for use in forming a glaze coating, or a base coating when said composition includes also a particulate material.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: December 13, 1988
    Assignee: Coatings for Industry, Inc.
    Inventors: James M. Klotz, Brian L. Klotz
  • Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical composition and use
    Patent number: 4788187
    Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: November 29, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
    Patent number: 4785101
    Abstract: Benzodiazinone-pyridazinone and -hydroxypyrazolyl compounds possess cardiotonic activity and are included in therapeutic cardiotonic compositions useful in methods for increasing cardiac contractility and for the treatment of congestive heart failure.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: November 15, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith, Bruce F. Molino
  • 6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
    Patent number: 4785005
    Abstract: This invention relates to 6-pyridone-carbostyril compounds, uses of said compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: November 15, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Henry F. Campbell, Donald E. Kuhla, Bruce F. Molino, William L. Studt
  • Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
    Patent number: 4783463
    Abstract: Compounds of the formula ##STR1## wherein: Het is imidazol-1-yl or 1,2,4-triazol-1-yl;py is 2-, 3-, or 4-pyridyl;R and R.sub.2 are H or alkyl;R.sub.1 is H, alkyl or vicinal R.sub.1 groups from a C--C double bond; and x is 0 or 1;or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions including the same for cardiotonic uses and methods of treating congestive heart failure.
    Type: Grant
    Filed: October 23, 1985
    Date of Patent: November 8, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith
  • Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4777168
    Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting parmacological activity, including anti-secretory and anti-ulcerogenic activity, pharaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: October 11, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
  • Bicyclic benzonoid alkylene amino thieno [3,4-D] isothiazole ethers and thioethethers, pharmaceutical compositions and use
    Patent number: 4748164
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcero-genic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: May 31, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Amidinoureas for treating irritable bowel syndrome
    Patent number: 4745131
    Abstract: 1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of Irritable Bowel Syndrome.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: May 17, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: John Yelnosky, Ghulam N. Mir
  • Process for the preparation of a viscosity-stable antacid composition
    Patent number: 4744986
    Abstract: A process for the preparation of a viscosity-stable antacid composition containing an alginic acid salt comprising reacting an antacid material with said salt at elevated temperatures to form a reaction product and recovering said reaction product in stabilized form.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: May 17, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Joseph R. Luber, Kenneth M. Feld, Richard J. Harwood, Wayne M. Grim
  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4745110
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: July 27, 1987
    Date of Patent: May 17, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4743600
    Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: May 10, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • 3- and 5-amino thiatriazines, and their pharmaceutical uses
    Patent number: 4742055
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including anti-ulcerogenic and gastrointestinal cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: May 3, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, Donald E. Kuhla, Henry F. Campbell, Stuart A. Dodson
  • Method for the treatment of pruritus and composition for the use therein
    Patent number: 4734434
    Abstract: A method for the relief of pruritus comprising the administration of an effective antipruritic amount of a N-(trifluoromethylphenyl)anthranilic acid ester to an afflicted patient.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: March 29, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Robert L. Procaccini, Kim D. Lamon, Nicholas S. Hagen