Abstract: The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.
Abstract: A method of generating a stream comprising synchronized interactive content is described. The method comprises the steps of: transmitting a first stream from a studio to a terminal or a terminal system of a first user and to a buffer; transmitting in response to the first stream a second stream to a mixer connected to the buffer, the second stream comprising content generated in reaction to the content of the first stream; providing the mixer with a temporal relation between the packets in the first and second stream; generating a first output stream comprising a substantially synchronized content by mixing packets in second stream with packets of the buffered first stream on the basis of the temporal relation.
Type:
Grant
Filed:
July 2, 2009
Date of Patent:
October 23, 2012
Assignee:
Koninklijke KPN N.V.
Inventors:
Hans Maarten Stokking, Omar Aziz Niamut, Mattijs Oskar van Deventer, Fabian Arthur Walraven, Victor Bastiaan Klos, John Gerard Beerends
Abstract: A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C1 . . . CN at each pixel from the set of images and reference spectral data for the N fluorophores. The coefficients C1 . . . CN are related to the concentration of each of the individual fluorophores at each pixel location. Morphological processing instructions find biological structures, e.g., cells, cellular components, genes, etc., in the images of the specimen. Quantitative analysis is performed on the identified biological structures. A display module displays the quantitative analysis results to the user, along with images of the specimen. The images can include images constructed from one or more of the coefficients C1 . . . CN.
Type:
Grant
Filed:
June 3, 2011
Date of Patent:
October 16, 2012
Assignee:
Ventana Medical Systems, Inc
Inventors:
G. Scott Lett, Ned C. Haubein, Gary Pestano
Abstract: Disclosed are compositions comprising and methods of using sulphated or phoshated polysaccharides for the treatment of diseases caused by herpes viruses, more particularly by alpha-herpes viruses, and in particular by HSV-1 and HSV-2, as well as by strains of these viruses which are resistant to known antiviral agents.
Abstract: The invention provides a single-step method for removing bulk metal contamination from III-V semiconductor substrates. The method comprises immersing a metal contaminated III-V semiconductor substrate in a mixture of sulfuric acid and peroxide with a volume ratio of sulfuric acid to peroxide (e.g., hydrogen peroxide) between about 3:1 and about 9:1. After treating the III-V semiconductor substrates with the sulfuric acid-peroxide mixture, the bulk metal contamination may be substantially removed from the substrate while a surface roughness of the substrate after treatment of below about 0.5 nm RMS (2 ?m×2 ?m) is obtained. The invention further provides a method for manufacturing a semiconductor device by removing bulk metal contamination according to the single-step method of the invention before performing processing steps for forming the semiconductor device.
Abstract: Particulate compositions are described comprising an intimate mixture of a coal and a gasification catalyst. The particulate compositions are gasified in the presence of steam to yield a plurality of gases including methane and at least one or more of hydrogen, carbon monoxide, carbon dioxide, hydrogen sulfide, ammonia and other higher hydrocarbons. Processes are also provided for the preparation of the particulate compositions and converting the particulate composition into a plurality of gaseous products.
Type:
Grant
Filed:
February 27, 2009
Date of Patent:
October 16, 2012
Assignee:
Greatpoint Energy, Inc.
Inventors:
Alkis S. Rappas, George Frederick Salem
Abstract: Human PGD genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of PGD are provided.
Type:
Grant
Filed:
June 20, 2005
Date of Patent:
October 16, 2012
Assignee:
Exelixis, Inc.
Inventors:
Chunyan Song, Michael Martin Ollmann, Lynn Margaret Bjerke
Abstract: A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C1 . . . CN at each pixel from the set of images and reference spectral data for the N fluorophores. The coefficients C1 . . . CN are related to the concentration of each of the individual fluorophores at each pixel location. Morphological processing instructions find biological structures, e.g., cells, cellular components, genes, etc., in the images of the specimen. Quantitative analysis is performed on the identified biological structures. A display module displays the quantitative analysis results to the user, along with images of the specimen. The images can include images constructed from one or more of the coefficients C1 . . . CN.
Type:
Grant
Filed:
June 3, 2011
Date of Patent:
October 16, 2012
Assignee:
Ventana Medical Systems, Inc.
Inventors:
G. Scott Lett, Ned C. Haubein, Gary Pestano
Abstract: A device (10) for capturing energy from a fluid flow is disclosed. The device (10) comprises a base (12) adapted for stationary mounting relative to the fluid flow. A member (20), having a longitudinal axis (21), is pivotally connected relative to the base (12) about a substantially vertical first pivotal axis (22) and is adapted to move relative to the base (12) towards a position in which the longitudinal axis (21) generally aligns with a vertical plane parallel to the direction of the fluid flow passing the member (20). A lift generating element (26) is connected to the member (20) and is movable relative to the direction of the fluid flow to vary a direction of lift produced by the lift generating element (26) as fluid flows therearound. The lift generated by the lift generating element (26) drives the member (20) in oscillatory motion relative to the base (12). An energy transfer mechanism is attached to the member (20) and is adapted to be driven by the oscillation of the member (20).
Abstract: A system and method for optimizing the frequency of market information updates in an electronic trading environment are described herein. According to one example embodiment, by optimizing the frequency of market information updates, the burden on the client device to update the graphical user interface may be reduced, while still providing an accurate portrayal of the market to the user. An example method includes associating different precedence levels with messages comprising market information. Messages containing market information related to the inside market may be associated to a higher precedence level. Whereas messages containing market information relating to the quantities at prices outside the inside market may be associated with a lower precedence level. Based on the precedence level associated with a message, a client device may update the graphical user interface or the message may be stored in a data structure until a pre-defined condition is satisfied.
Type:
Grant
Filed:
December 21, 2006
Date of Patent:
October 16, 2012
Assignee:
Trading Technologies International, Inc.
Abstract: A user (102) hears an audio program being broadcast and can record a sample of the audio. The sample is then conveyed to an analyzing means (106) to determine to which broadcast station the user is listening. The analyzing means monitors many broadcast channels. Thus, characteristics of the audio sample and samples taken from the broadcast channels can be compared to find a match. Broadcast information pertaining to the broadcast channel from which the match was found may then be reported back to the user, combined with an advertisement of a promotion, prize notification, discount offers, and other information specific for a certain radio station for example.
Abstract: A system and methods are provided for using order descriptor identifiers in relation to orders being used in trading strategies. According to one example method, when a hedge order is submitted upon detecting a fill of another order, the hedge order includes one or more order descriptor identifiers conveying a purpose of the hedge order to a user. The order descriptor identifiers can be used to search for desired orders and perform more effective order management and post trade analysis.
Type:
Grant
Filed:
July 27, 2010
Date of Patent:
October 16, 2012
Assignee:
Trading Technologies International, Inc.
Abstract: Breastpumps and methods for use in extracting breastmilk, which can be used to generate, among other things, both a letdown or stimulation phase and a milk expression phase, are disclosed.
Type:
Grant
Filed:
April 14, 2003
Date of Patent:
October 9, 2012
Assignee:
Medela Holding AG
Inventors:
Andy Greter, Richard S. Weston, Brian H. Silver, Michael Larsson
Abstract: The invention mostly uses conventional procedures with regard to enabling specific end-user to decrypt encrypted content information, but supplies the decryption keys, which are identical for all end-users, only after the end-user has received the encrypted content information and after the end-user has received the subscription information comprised in the specific entitlement management data that specifies the individual rights to access the content information. This approach provides additional control over the conditions under which the content information is played-out by the end-user, and enables to temporally better manage the communication bandwidth available to the service provider.
Type:
Grant
Filed:
July 23, 2009
Date of Patent:
October 9, 2012
Assignees:
Koninklijke KPN N.V., Nederlandse Organisatie voor Toepast-Natuurwetenschappelijk Onderzoek TNO
Abstract: The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
Type:
Grant
Filed:
September 4, 2009
Date of Patent:
October 9, 2012
Assignee:
Elan Pharmaceuticals, Inc.
Inventors:
Andrei W. Konradi, Xiaocong Michael Ye, Simeon Bowers, Albert W. Garofalo, Danielle L. Aubele, Darren Dressen, Raymond Ng, Gary Probst, Christopher M. Semko, Minghua Sun, Anh P. Truong, Michael S. Dappen
Abstract: A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C1 . . . CN at each pixel from the set of images and reference spectral data for the N fluorophores. The coefficients C1 . . . CN are related to the concentration of each of the individual fluorophores at each pixel location. Morphological processing instructions find biological structures, e.g., cells, cellular components, genes, etc., in the images of the specimen. Quantitative analysis is performed on the identified biological structures. A display module displays the quantitative analysis results to the user, along with images of the specimen. The images can include images constructed from one or more of the coefficients C1 . . . CN.
Type:
Grant
Filed:
June 3, 2011
Date of Patent:
October 9, 2012
Assignee:
Ventana Medical Systems, Inc.
Inventors:
G. Scott Lett, Ned C. Haubein, Gary Pestano
Abstract: The present invention relates to novel tricyanoborates of the general formula Catn+[B(CN)3(XR1)]—n, wherein R1 is C1-6 alkyl, C2-6 alkenyl, C6-10 aryl or benzyl; X is oxygen or sulfur; and Catn+ is a cation with n being 1 or 2, which is selected from the group consisting of an inorganic cation and an organic cation; and also their preparation and use.
Abstract: A method for removing a hardened photoresist from a semiconductor substrate. An example method for removing a hardened photoresist layer from a substrate comprising a low-? dielectric material preserving the characteristics of the low-?dielectric material includes: a)—providing a substrate comprising a hardened photoresist layer and a low-? dielectric material at least partially exposed; b)—forming C?C double bonds in the hardened photoresist by exposing the hardened photoresist to UV radiation having a wavelength between 200 nm and 300 nm in vacuum or in an inert atmosphere; c)—breaking the C?C double bonds formed in step b) by reacting the hardened photoresist with ozone (O3) or a mixture of ozone (O3) and oxygen (O2) thereby fragmenting the hardened photoresist; and d)—removing the fragmented photoresist obtained in step c) by wet processing with cleaning chemistries.
Type:
Grant
Filed:
September 17, 2009
Date of Patent:
October 2, 2012
Assignee:
IMEC
Inventors:
Quoc Toan Le, Els Kesters, Guy Vereecke
Abstract: A vehicle suspension including a spring module and a spring mount positioned within an opening in the spring module with two shear springs on either side of the spring mount, wherein the spring mount includes an inboard part and an outboard part, and a through-hole positioned in the inboard or outboard part to allow passage of a threaded connecting rod therethrough that has been tightened to draw the inboard part of the first spring mount together with the outboard part of the first spring mount, and to compress the first shear spring between a first side wall of the spring mount and a first side wall of the opening, and also to compress a second shear spring between a second side wall of the spring mount and a second side wall of the opening.
Type:
Grant
Filed:
September 15, 2011
Date of Patent:
October 2, 2012
Assignee:
Hendrickson USA, L.L.C.
Inventors:
Shawn D. Noble, Hormoz Kerendian, Ashley T. Dudding