Abstract: A method, system, apparatus, and computer-readable medium are provided for taking snapshots of a storage volume. According to aspects of one method, each snapshot is represented as a unique sequence number. Every fresh write access to a volume in a new snapshot lifetime is allocated a new section in the disk, called a provision, which is labeled with the sequence number. Read-modify-write operations are performed on a sub-provision level at the granularity of a chunk. Because each provision contains chunks with valid data and chunks with invalid data, a bitmap is utilized to identify the valid and invalid chunks with each provision. Provisions corresponding to different snapshots are arranged in a linked list. Branches from the linked list can be created for storing writable snapshots. Provisions may also be deleted and rolled back by manipulating the contents of the linked lists.

Abstract: A flexible element that may be configured, among various uses, as an intervertebral implant for insertion into an intervertebral disc space between adjacent vertebral bodies or between two bone portions. The flexible element includes one or more struts extending from superior and inferior endplates and bending towards one another for connection with one or more internal beams.

Abstract: Technologies are described herein for achieving data consistency during a failover from a primary node to a secondary node in a storage cluster with a shared RAID array in a degraded mode. When the primary storage node receives a write I/O operation, a volume module on the primary node reads the missing data strip data from the failed disk belonging to the stripe targeted by the write I.O operation. The primary storage node communicates the missing data strip to the secondary storage node, which writes the missing strip data to an outstanding strip log. Upon the failure of the primary node, the secondary storage node reads the missing data strip from the outstanding strip log and writes the missing data strip to the shared RAID array, thus restoring data consistency to the stripe of the RAID array containing the missing data strip.

Abstract: Technologies are described for implementing a migration mechanism in a data storage system containing multiple tiers of storage with each tier having different cost and performance parameters. Access statistics can be collected for each territory, or storage entity, within the storage system. Data that is accessed more frequently can be migrated toward higher performance storage tiers while data that is accessed less frequently can be migrated towards lower performance storage tiers. Each tier can be associated with a range of ILM statistics referred to as the bucket for that tier. A pivot table may be provided that relates the tiers and the buckets. Operations on the pivot table can provide counts of how many territories may be promoted or demoted between any two pairs of tiers.

Abstract: Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).

Abstract: The present invention provides methods and compounds for inhibiting HEC1 activity for the treatment of diseases involving cell hyperproliferation, e.g. cancer. The present invention also provides methods of identifying compounds for inhibiting HEC1 activity.

Abstract: Methods and system for preventing or allowing an installer application from installing applications based on a comparison of the installer application actions to profiles and rules. The profiles and rules are established (and periodically updated) to identify a particular software installation process as undesirable and stop it from occurring. An install blocker processes the profiles and rules and compares them against what the installer is trying to do as part of its installation process. If the installer is attempting to install an application deemed undesirable, the user could then be notified, provided all of the information about what the installer was trying to do, and provided choice to allow the installation to continue.

Abstract: Techniques for maintaining mirrored storage cluster data consistency on systems with write back cache can employ write-intent logging and periodic log clearing. The techniques can track any outstanding I/Os, data in caches, and data that has gone out of sync between mirrored nodes due to link failures. The techniques can ensure that a power failure on any of the storage nodes does not result in inconsistent data among the storage nodes. The techniques can use gate bitmaps to log outstanding I/Os. The gate bitmaps may be periodically cleared. The clearing period may be selected as to allow enough time for all caches to be flushed and for all synchronizing I/Os to complete. Efficient queuing of I/O requests in conjunction with the efficient operation of multiple gate bitmaps can reduce performance impacts of the gating or logging operations.

Abstract: Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

Abstract: The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.

Abstract: The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.

Abstract: A moisture vapor permeable, water impermeable composite sheet material is provided which is suitable for use as a housewrap material, and is also useful for other applications such as tarpaulins, or as covers for automobile, boats, patio furniture or the like. The composite sheet material includes a nonwoven substrate and an extrusion-coated polyolefin film layer overlying one surface of the substrate. The nonwoven substrate is comprised of polymeric fibers randomly disposed and bonded to one another to form a high tenacity nonwoven web. The nonwoven substrate has a grab tensile strength of at least 178 Newtons (40 pounds) in at least one of the machine direction (MD) or the cross-machine direction (CD). The extrusion coated polyolefin film layer is intimately bonded to the nonwoven substrate. The film layer has micropores formed therein to impart to the composite sheet material a moisture vapor transmission rate (MVTR) of at least 35 g/m2/24 hr. at 50% relative humidity and 23° C.

Abstract: The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from or suspected of having neurodegenerative diseases or conditions.

Abstract: The invention is a method of producing an essentially electrically neutral polymer dispersion, comprising a polymerizing one or more monomers in the presence of a nonionic surfactant, wherein the polymerization preferably occurs in the absence of ionic surfactants. The invention also includes methods of producing positively or negatively charged polymer dispersions comprising producing the essentially nonionic polymer dispersion and further adding a cationically-charged or anionically-charged surfactant or electrolyte. The invention further includes dispersions produced by the methods of the invention and polymer films and powders produced from these dispersions.

Abstract: An expandable interspinous process spacer implant for insertion and/or implantation between a spinous process of a superior vertebral body and a spinous process of an inferior vertebral body, the implant comprising multiple pairs of legs joined in a scissor-like fashion and pivotally coupled to each other by one or more pins, where each leg has multiple slots along its longitudinal axis. The implant further may include a pair of bearing surfaces coupled between the legs via cross pins and a first plate and second plate each of which is coupled to a pair of roller pins disposed between a pair of slots on the legs where rotation of a fastener in the fastener holes of the first and second plate results in the first plate and the second plate being drawn toward each other causing the expansion of the height of the implant.

Abstract: Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).

Abstract: A method of uniformly transferring luminescent quantum dots onto a substrate, comprising: a) preparing a colloidal suspension of luminescent quantum dots in a hydrophobic solvent, wherein the density of the hydrophobic solvent is from 0.67 g/cm3 to 0.96 g/cm3; b) dispensing the suspension onto a convex aqueous surface; c) allowing the hydrophobic solvent to evaporate; d) contacting the film of luminescent quantum dots with a hydrophobic stamp; and e) depositing the film of luminescent quantum dots onto a substrate with the hydrophobic stamp is described herein. Further described is a method of preparing quantum dot based light emitting diodes.

Abstract: The connecting element (1) has the shape of a rod with longitudinal axis (2), a rear end (6), and a front end (7), and serves to span a number of bone anchoring elements (12) implanted in the bone. The connecting element (1) comprises at least one longitudinal slot (5). This provides it with a greater elasticity during implantation so that it can be reversibly deformed. The connecting element can then be stiffened once it has been fixed in the bone anchoring elements (e.g. pedicle screws).

Abstract: A video indexing system uses pictures representative of a recorded video program to assist a user in determining the contents of a recorded medium without having to view the program itself. The pictures preferably represent segments of the program which are spaced apart in time, enabling a relatively small number of such pictures to characterize a lengthy program, and are presented in separate windows on the screen of the same device used to display the video program. The pictures may include still or moving imagery. A viewer optionally may select a particular picture with a pointing device, to commence replay of the recorded program from that period in the program, or to recall stored audio information so as to assist in identifying the selection. The picture information may be stored on the same medium as that used to record the video program, or a different medium may be used.

Abstract: Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.