Abstract: Effective dosing regimens for neural stem cell proliferating and differentiating agents, kits comprising effective dosing regimens for neural stem cell proliferating and differentiating agents, and uses thereof are provided herein. Such kits and methods can be utilized acutely or chronically to treat a neurodegenerative disease or condition. Furthermore, the compositions and methods can be used continuously or intermittently in various dosing regimens.

Abstract: A process for the removal of sterols, specifically cholesterol, from a triglyceride oil, preferably a marine triglyceride oil, said process comprising contacting an oil with an adsorbent, specifically TRIS YL™, clay or a mixture thereof, heating the mixture to 100° C. to 210° C., preferably 150° C. to 170° C., preferably for a time period of greater than one minute and optionally at a pressure less than 133 Pa, preferably less than 1.33 Pa.

Abstract: Technologies are described for implementing a system that schedules background workflows in a storage system. Historical load statistics can be analyzed to estimate the preferred times in the future during which to schedule background workflows. After collecting load statistics related to the storage system, natural cyclical patterns in the load data can be determined as the predominant periodicities of the load data are selected from peaks in an autocorrelation of the collected data. A linear predictor may be formed as a weighted sum of the historical data sampled at the determined periodicities. Error minimization, such as the method of least squares, may be used to determine the values of the weighting in order to minimize an error between the load predictor and the measured load. Predicting future loads can improve the scheduling of background operations by avoiding conflicts with normal system operations.

Abstract: Methods, systems, and apparatus for optical imaging and patterning based on a magnetically controlled ferrofluid are described. One such system includes a substrate and an active region including multiple magnetic field generators. The active region is positioned adjacent to the substrate. The system includes a ferrofluid positioned on the substrate adjacent the active region within a range of a magnetic field of the multiple magnetic field generators. The ferrofluid is distributed across multiple ferrofluid regions. Each magnetic field generator is aligned with a corresponding ferrofluid region.

Abstract: An intervertebral implant with a central axis, a top part, a bottom part, a joint comprising a joint part and a joint shell, and a joining means. The top part has a top apposed surface that is suitable for placing it on a vertebra situated above it; The bottom part has a bottom apposed surface, that is suitable for placing it on a vertebra situated below it. One of the two parts is operatively associated with a convex joint part and the other part to a matching joint shell. The joint part and the joint shell are mounted against one another in a sliding manner such that the top part and the bottom part can rotate relative to one another at least about one axis of rotation. The joining means holds the top part and the bottom part together without impairing the capability of the joint to pivot while allowing a clearance between the joint part and the joint shell.

Abstract: Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.

Abstract: A process for separating a sperm type from a sperm population by electrophoresis comprising subjecting the sperm population to an electric potential such that a sperm type is separated from a sperm population through an ion-permeable barrier.

Abstract: Technologies for high capacity storage servers with thin provisioning can support an increased storage capacity and an increased number of snapshots within a data storage system while maintaining a reduced memory footprint. Flexible virtual address translation can support both direct, and indirect, translation from a virtual address to an address in physical storage. A data structure, referred to as a volume table, may be provided for supporting the virtual to physical address translation. Multiple volume tables for the various volumes within a data storage system can be stored together in a global volume table. Granularities of storage allocation units, such as territories, provisions, and chunks can be reduced to improve efficiencies in the operation of the storage system. Processes for handling volume and snapshot I/O operations with various data structures can contribute to improved efficiencies while supporting increased storage capacities and an increased number of snapshots.

Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.

Abstract: Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.

Abstract: A method, system, apparatus, and computer-readable medium are provided for taking snapshots of a storage volume. According to aspects of one method, each snapshot is represented as a unique sequence number. Every fresh write access to a volume in a new snapshot lifetime is allocated a new section in the disk, called a provision, which is labeled with the sequence number. Read-modify-write operations are performed on a sub-provision level at the granularity of a chunk. Because each provision contains chunks with valid data and chunks with invalid data, a bitmap is utilized to identify the valid and invalid chunks with each provision. Provisions corresponding to different snapshots are arranged in a linked list. Branches from the linked list can be created for storing writable snapshots. Provisions may also be deleted and rolled back by manipulating the contents of the linked lists.

Abstract: Valve arrangements for use with a water meter include a first valve comprising a first valve housing, a first inlet, and a first outlet, the first inlet and the first outlet of the first valve being oriented substantially perpendicular to one another, a second valve comprising a second valve housing, a second inlet, and a second outlet, the second inlet and the second outlet of the second valve being oriented substantially perpendicular to one another; the first inlet of the first valve and the second outlet of the second valve being substantially coaxial with one another, and the first outlet of the first valve and the second inlet of the second valve being oriented substantially 180° apart from one another, with the first valve housing and the second valve housing being joined together by a connection member. The valve arrangement may also be provided as a kit of parts with a set of pipeline attachment members.

Abstract: A passive noise attenuation device and system is provided having a reticulated open-cell porous structure configured to acts as a passive control device in order to mitigate combustion noise and instability problems in combustion systems. A porous inert media structure is placed downstream of the reaction zone of a combustion chamber to dissipate noise and/or instability generated upstream in the flame. The porous inert media also limits and/or disintegrates vortical structures in the flame to produce a homogeneous flow field to facilitate distributed reaction zones.

Abstract: Technologies for efficient synchronous replication across heterogeneous storage nodes can provide the performance of high-speed storage units while leveraging low-cost and high-capacity backup storage units within the same system. The performance of low-cost, high-capacity hard disks may be improved by initially storing data into sequential physical locations. A sequential journal of I/Os may be used in a replicated secondary node to allow for rapid completion of I/Os. A separate background process can later scatter the sequentially logged I/O data into its proper location for storage. A programmable n-way router can be configured to route I/Os as needed to improve overall performance of the storage unit. A secondary node log device can also be used to provide continuous data protection (CDP). Lastly, packetizing together I/Os prior to delivery to a secondary node may reduce interrupts and context switches in the primary node, thereby improving performance of the storage system.

Abstract: Systems and methods are disclosed for an optimizing operations at a contact center. In one embodiment, an integrated contact center comprises: a workforce manager comprising a scheduler and a tracking function; and a lesson assignment function configured to receive at least one indicator of performance of the agent, and further configured to assign a lesson to the agent based on the at least one indicator.

Abstract: A rotatable building structure that comprises: a vertically extending building having one or more floors; a fixed core support for supporting the building, located substantially centrally beneath the building; a rotatable annular drive system for rotating the building, located lower than the building and with its centre substantially aligned with the vertical centerline of the building, the system having an upper surface and a planar lower surface; and a fixed outer support, located beneath the annular drive system, the support having a planar upper surface that contacts the planar lower surface of the annular drive system; wherein at least one of the lower surface of the annular drive system and the upper surface of the fixed outer support is a bearing material, permitting rotation of the annular drive system over the fixed outer support, such that the annular drive system is rotated via a planar to planar bearing system.

Abstract: Included are embodiments for providing communications data. At least one embodiment of a method receiving data associated with a communications session, the communications session including a first communications stream and a second communications stream, wherein the first communications stream and the second communications stream are received in a receiving order and recording at least a portion of the communications session. Some embodiments include receiving a request to provide, from the recording, at least a portion of the first communications stream in a visual format and providing at least a portion of the first communications stream in the visual format.

Abstract: The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector comprising an HSV origin of replication, an HSV cleavage/packaging signal, and a heterologous transgene expressible in a patient, (ii) one or more vectors individually or collectively encoding all essential HSV genes but excluding all cleavage/packaging signals, and (iii) a vhs expression vector encoding a virion host shutoff protein; and then isolating HSV amplicon particles produced by the host cell, the HSV amplicon particles including the transgene. Also disclosed are a system and a kit for preparing HSV amplicon particles, HSV amplicon particles prepared according to the process of the present invention, and their use.

Abstract: A process for separating a cell type from a mixture of cell types by electrophoresis comprising providing a sample containing a mixture of cell types to a sample chamber of membrane-based electrophoresis apparatus adapted to separate cells and applying an electric potential causing at least one cell type in the sample to be separated from other cells in the sample.

Abstract: Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.