Patents Represented by Attorney Michael C. Sudol

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  • Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives
    Patent number: 4594341
    Abstract: There are disclosed perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: June 10, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Yak-Fa Cheung, Eugene D. Thorsett, Arthur A. Patchett
  • 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
    Patent number: 4593039
    Abstract: 1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have .beta.-adrenergic blocking activity with some cardioselectivity and hence are useful as antihypertensive, antianginal, antiarrhythmic and cardioprotective agents and in the treatment of elevated intraocular pressure such as glaucoma.
    Type: Grant
    Filed: April 2, 1984
    Date of Patent: June 3, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Sandor L. Varga, Gerald S. Ponticello
  • Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
    Patent number: 4593033
    Abstract: Novel substituted indeno[2,1-c] pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: June 3, 1986
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Wasyl Halczenko, Steven D. Young
  • Cyclopropyl pyridine compounds useful as calcium channel blockers
    Patent number: 4591587
    Abstract: Novel cyclopropyl pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: May 27, 1986
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • Polyelectrolyte and surfactant compositions for controlling alkaline earth metal scales
    Patent number: 4589985
    Abstract: The instant invention is directed to a method of inhibiting the precipitation and deposition of alkaline earth metal scales in an aqueous system, comprising adding to said system an effective amount of (a) an anionic polyelectrolyte; and (b) an anionic surfactant, wherein said polyelectrolyte/surfactant ratio ranges from 1000:1 to 1:10, by weight.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: May 20, 1986
    Assignee: Calgon Corporation
    Inventor: Monica A. Yorke
  • Process for the preparation of cyclopropyl pyridine compounds useful as calcium channel blockers
    Patent number: 4590276
    Abstract: A novel process for the preparation of cyclopropyl pyridine compounds, which are useful as calcium channel blockers, is disclosed.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: May 20, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Stella W. King
  • 5-amino or substituted amino 1,2,3-triazoles
    Patent number: 4590201
    Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: May 20, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Richard J. Bochis, John C. Chabala, Michael H. Fisher
  • N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds and .alpha..sub.2 -adrenergic antagonistic uses thereof
    Patent number: 4590202
    Abstract: N-(2-Imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds are disclosed. The compounds have the property of inhibiting calcium induced contraction of smooth muscle. Certain of the compounds have properties of .alpha..sub.2 -adrenergic antagonists and others of .alpha..sub.2 -adrenergic agonists.
    Type: Grant
    Filed: January 19, 1984
    Date of Patent: May 20, 1986
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • Preparation of epihalohydrin enantiomers
    Patent number: 4588824
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: May 13, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Process for epimerization at C.sub.6 of 3,4,5,6-tetrahydro-2H-pyran-2-one
    Patent number: 4588820
    Abstract: An external bond at the 6-position of a 3,4,5,6-tetrahydro-2H-pyran-2-one, as found in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, is readily epimerized by treating an amide of the corresponding hydroxy acid with a sulfonyl chloride reagent.
    Type: Grant
    Filed: June 11, 1984
    Date of Patent: May 13, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Gerald E. Stokker
  • Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
    Patent number: 4587247
    Abstract: Novel substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones are useful as anthelmintic and antiparasitic agents. The compounds are also useful as pesticides and insecticides against agricultural pests. Included herein are novel intermediates useful in the process for preparing said avermectin aglycone derivatives. Compositions of said derivatives and methods of administering said compositions are also disclosed.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Bruce O. Linn, Helmut H. Mrozik
  • Bridged pyridine compounds useful as calcium channel blockers and analgesics
    Patent number: 4587253
    Abstract: Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • Substituted caprylolactam derivatives as anti-hypertensives
    Patent number: 4587238
    Abstract: The invention in its broad aspects relates to caprylolactam derivatives which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 9, 1982
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Substituted enantholactam derivatives as antihypertensives
    Patent number: 4587050
    Abstract: The invention in its broad aspects relates to enantholactam derivatives which are useful as angiotensin converting enzyme inhibitors and antihypertensives.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Eugene D. Thorsett, Arthur A. Patchett
  • 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
    Patent number: 4585787
    Abstract: 5-[2(or 3)-Hydroxyphenylsulfonyl]thiophene-2-sulfonamides are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are disclosed.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: April 29, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Kenneth L. Shepard
  • Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
    Patent number: 4585755
    Abstract: Cyclic and bridged cyclic somatostatin analogs have been found to be useful as local anti-inflammatory agents in the treatment of such conditions, as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: April 29, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Evan R. Morgan, Sanford L. Steelman
  • Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
    Patent number: 4584294
    Abstract: The invention relates to fused tricyclic lactams and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: November 7, 1984
    Date of Patent: April 22, 1986
    Assignee: Merck & Co., Inc.
    Inventor: William V. Ruyle
  • Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use
    Patent number: 4581345
    Abstract: There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presence of an activated form of zinc. The avermectin 8,9-cyclopropyl compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: April 8, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Matthew J. Wyvratt, Jr.
  • Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
    Patent number: 4579864
    Abstract: There are disclosed novel avermectin and milbemycin compounds wherein the 13-position is oxidized to a keto function. The 13-keto derivatives are prepared from the 13-hydroxy compounds by oxidizing the 13-position with a suitable oxidizing agent. The avermectin and milbemycin 13-keto derivatives are active in their own right and also serve as intermediates in the preparation of 13-imino and 13-amino derivatives. The 13-keto, imino and amino compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.
    Type: Grant
    Filed: June 11, 1984
    Date of Patent: April 1, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Bruce O. Linn, Helmut H. Mrozik
  • Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
    Patent number: 4578509
    Abstract: A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: March 25, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Seemon H. Pines, Edward J. J. Grabowski