Patents Represented by Attorney Michael C. Sudol

Find this attorney in the Justia Lawyer Directory

  • Antihypercholesterolemic beta-lactones
    Patent number: 4751237
    Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or C.sub.1-3 alkyl and the tetrahydro analogs thereof, are 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would by useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: June 14, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Arthur A. Patchett, Michael D. Greenspan
  • Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
    Patent number: 4751231
    Abstract: Thieno[2,3-b]pyrrole-5-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: June 14, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • Novel lysine esters used as absorption
    Patent number: 4749694
    Abstract: Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as pharmaceutical formulations and methods for their use as absorption enhancing agents.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: June 7, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Joseph A. Fix, Stefano A. Pogany
  • Dosage device
    Patent number: 4747521
    Abstract: A dosage device for the delivery of a measured quantity of a liquid or flowable paste, such as a medicament, comprises a cup component and a compartmented component which is secured within the cup component and rotatable with respect thereto about an axis, the cup component having a radial base wall with an opening radially offset from the axis, the compartmented component having axially extending walls bounding a plurality of compartments each of which has an open end and each of which can be brought, by relative rotation of the two components, into alignment with the base wall opening, each compartment having in its outer wall an outlet which is at a respective different axial spacing from its open end, the cup component and that outer wall bounding a dispensing space to receive liquid or flowable paste from the compartment.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: May 31, 1988
    Assignee: Merck & Co., Inc.
    Inventor: Ronald G. Saffron
  • Compounds having somatostatin-like activity useful as local anti-inflammatory agents
    Patent number: 4748153
    Abstract: Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particularly useful are cyclic and bridged somatostatin analogs.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: May 31, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Evan R. Morgan, Daniel F. Veber, Sanford L. Steelman
  • Diastereocontrolled synthesis of 2-amino alcohols
    Patent number: 4743694
    Abstract: The addition of organolithium to dimethylhydrazones of certain ethers of a-hydroxyaldehydes results in the synthesis of threo- or erythro- intermediates readily convertible to threo- or erythro-2-amino alcohols.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: May 10, 1988
    Assignee: Mercek & Co., Inc.
    Inventor: David A. Claremon
  • HMG-CoA reductase inhibitors
    Patent number: 4738982
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): ##STR1## and pharmaceutically acceptable salts thereof the compounds of the formula (II) in which R is hydrogen are disclosed.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: April 19, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Michael D. Greenspan, Joel B. Yudkovitz
  • Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety
    Patent number: 4735961
    Abstract: Novel substituted aminohydroxypropoxyphenyl oxazole and thiazole compounds and methods for their preparation are disclosed. These compounds, and their salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and antianginal agents.
    Type: Grant
    Filed: November 5, 1985
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
    Patent number: 4735956
    Abstract: Novel substituted 4-heteroaryl-1,4-dihydropyridine compounds useful as calcium channel blockers, pharmaceutical compositions therof, and methods of treatment are disclosed.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Wasyl Halczenko, George D. Hartman, Brian T. Phillips
  • Prodrugs of antihypercholesterolemic compounds
    Patent number: 4736064
    Abstract: Prodrugs of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## and pharmaceutically acceptable salts thereof are disclosed.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Wasyl Halczenko, George Hartman
  • Drug delivery device which can be retained in the stomach for a controlled period of time
    Patent number: 4735804
    Abstract: Drug delivery device retained in the stomach comprising at least one drug and a continuous solid-stick figure made from polymer(s) that releases said drug slowly over a controlled, predictable and extended period of time.
    Type: Grant
    Filed: May 7, 1987
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Larry J. Caldwell, Colin R. Gardner, Robyn C. Cargill
  • Tamper evident overcap
    Patent number: 4733787
    Abstract: There is disclosed an overcap for a container with a primary cap for the removal of the contents thereof, whereby the overcap is easily assembled onto the container and completely surrounds the primary cap. When assembled, the overcap prevents access to the primary cap, and when removed, the overcap becomes irreversibly deformed such that visual evidence is clearly apparent that access to the primary cap has been gained. The irreversible deformity consists of tabs connecting the pull-tab to the overcap, and weakened areas in the side of the overcap which must be torn to allow removal of the primary cap.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: March 29, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Norman D. Knopf, Heinz P. Meyer, Abraham Leibson
  • Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor
    Patent number: 4734421
    Abstract: Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: March 29, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Robert A. Zambias
  • Compounds useful in treating sickle cell anemia
    Patent number: 4731473
    Abstract: The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein: R=ethyl, propyl or isopropyl; andA=(CH.sub.2).sub.n wherein n is 2, 4 or 5, and C(CH.sub.2).sub.3.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Donald J. Abraham, Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
  • Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
    Patent number: 4731360
    Abstract: Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jose Alexander, A. J. Repta, Joseph A. Fix
  • Thienopyridine sulfonamides and their ophthalmological formulation
    Patent number: 4731368
    Abstract: Thienopyridine sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and disorders associated therewith such as glaucoma.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jacob M. Hoffman, Jr., Kenneth L. Shepard
  • Bicyclic lactams as antihypertensives
    Patent number: 4731444
    Abstract: There are disclosed bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Matthew J. Wyvratt, Jr.
  • Method of treating a person for sickle cell anemia
    Patent number: 4731381
    Abstract: The present invention is directed to a method of treating a person for sickle cell anemia comprising administering to the person a therapeutically effective dosage of a compound of the general formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R=ethyl, propyl or isopropyl; and ##STR2##
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Donald J. Abraham, Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Biosoluble ocular insert
    Patent number: 4730013
    Abstract: Ocular inserts with or without pharmacologically active agents comprising low molecular weight polymers have a lower propensity to cause blurred vision compared with inserts prepared from high molecular weight hydroxypropyl cellulose. When an enteric coating material is included as a constituent of the matrix there is provided a means for controlling and predicting dissolution rates of the insert to yield a prolonged residence time.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: March 8, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Joseph V. Bondi, Richard J. Harwood
  • Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts
    Patent number: 4729989
    Abstract: Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: March 8, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jose Alexander, Joseph A. Fix