Patents Represented by Attorney Michael C. Sudol

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  • Benzocycloheptapyridone compounds for treating congestive heart failure
    Patent number: 4639457
    Abstract: Novel benzocycloheptapyridone compounds are disclosed. The compounds exhibit inotropic potencies and are adaptable to being utilized as cardiotonic agents in the chemotherapeutic treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: January 27, 1987
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • 3',6-diisopentenyl-2',4'-dihydroxy-5,7-dimethoxy-isoflavan and related compounds useful as anxiolytic agents and avermectin antidotes
    Patent number: 4639466
    Abstract: 3',6-Diisopentenyl-2',4'-dihydroxy-5,7-dimethoxyisoflavan has been isolated from Glycyrrhiza uralensis Fisch. It has been found that this compound and other related compounds are potent stimulators of benzodiazepine receptors and thereby useful as effective anxiolytic agents. Furthermore, these compounds have been found to be potent antidotes of avermectin.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: January 27, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Leeyuan Huang, Y. K. Tony Lam
  • Polymers containing pendant acid functionalities and labile backbone bonds
    Patent number: 4639366
    Abstract: The instant invention is directed to a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units.The instant invention is also directed to a controlled release device which comprises:(A) a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units; and(B) a beneficial substance incorporated within or surrounded by the matrix of said polymer.
    Type: Grant
    Filed: June 6, 1984
    Date of Patent: January 27, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Jorge Heller
  • Substituted cephalosporins as anti-inflammatory and antidegenerative agents
    Patent number: 4637999
    Abstract: Substituted cephalosporins are found to be potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 2, 1983
    Date of Patent: January 20, 1987
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Paul E. Finke, Raymond A. Firestone, Shrenik S. Shah, Kevan R. Thompson
  • Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
    Patent number: 4634716
    Abstract: Compounds of the formula: ##STR1## where R.sup.3 is ##STR2## where n is 1-3 and the R.sup.a 's and R.sup.b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are inhibitors or angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: January 6, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, David Taub
  • Aza analogs of carboxyalkyl dipeptide derivatives as antihypertensives
    Patent number: 4634715
    Abstract: There are disclosed aza analogs of carboxyalkyl dipeptide derivatives and related compounds which are useful as converting enzyme inhibitors and as antihypertensives said compounds being represented by the general formula: ##STR1## wherein A and B can be joined together to form various ring structures.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: January 6, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Eugene D. Thorsett
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4629787
    Abstract: The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: December 16, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Amino acid derivatives as enzyme inhibitors
    Patent number: 4626545
    Abstract: Compounds of the formula ##STR1## and their use as angiotensin converting enzyme inhibitors and antihypertensives are disclosed.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: December 2, 1986
    Assignee: Merck & Co., Inc.
    Inventor: David Taub
  • 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
    Patent number: 4626542
    Abstract: Pharmaceutical compositions comprising 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds and the use of 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treatment of certain cardiovascular disorders are disclosed.
    Type: Grant
    Filed: April 5, 1984
    Date of Patent: December 2, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Stella W. King, David C. Remy
  • O-sulfate derivatives of avermectins and milbemycins having improved water solubility
    Patent number: 4622313
    Abstract: There are disclosed novel O-sulfate derivatives of avermectin and milbemycin. The avermectin and milbemycin O-sulfate derivatives have improved water solubility compared to the parent avermectin and milbemycin compounds and have utility as anti-parasitic agents and as potent insecticides against agricultural pests.
    Type: Grant
    Filed: August 1, 1985
    Date of Patent: November 11, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Matthew J. Wyvratt, Jr.
  • Resolution of racemic derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrro le-2-carboxylic acid and analogs
    Patent number: 4622407
    Abstract: Racemic mixture of derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole -2-carboxylic acid and analogs were resolved into pure l- or d-isomers via concomitant isomerization and functional crystallization.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: November 11, 1986
    Assignee: Merck & Co., Inc.
    Inventor: William K. Hagmann
  • Antiprotozoal 3-amino or substituted amino pyrazoles
    Patent number: 4622330
    Abstract: Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.
    Type: Grant
    Filed: June 19, 1984
    Date of Patent: November 11, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Richard J. Bochis, Richard A. Dybas, Edward F. Rogers
  • 3-hydroxybenzo[b]thiophene-2-sulfide derivatives compositions, and method of use therefor
    Patent number: 4621091
    Abstract: 3-hydroxybenzo[b]thiophene-2-sulfide derivatives have been prepared by ring closure of an appropriately substituted 2--R.sup.1 SCH.sub.2 S-- benzoic acid ester in the presence of a strong base. These compounds have been found to be specific inhibitors of 5-lipoxygenase and thereby useful in the treatment of inflammation, pain and fever associated with inflammation, arthritic conditions, asthma, allergic disorders such as allergic rhinitis and chronic bronchitis, skin diseases like psoriasis and atopic exzema, cardiovascular or vascular disorders, and other leukotriene mediated diseases. Furthermore, these compounds have been found to exhibit cytoprotective activity which does not involve the inhibition of gastric acid secretion but can be used at relatively low dosages for increasing the resistance of gastro-intestinal mucosa to strong irritants.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: November 4, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Allan N. Tischler, Thomas J. Lanza, Jr.
  • Process for the preparation of biphenyl intermediates
    Patent number: 4620025
    Abstract: A novel process for the preparation of intermediates in the totally synthetic antihypercholesterolemic agents, 6-[2-[1,1'-biphenyl]-2-yl-ethenyl] pyranones, involving a highly efficient nickel catalyzed aryl cross-coupling reaction is disclosed.
    Type: Grant
    Filed: August 1, 1984
    Date of Patent: October 28, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Meyer Sletzinger, Thomas R. Verhoeven
  • Carboxylic/sulfonic/polyalkylene oxide polymer for use as scale, corrosion, and iron oxide deposit control
    Patent number: 4618448
    Abstract: The instant invention is directed to a process for inhibiting corrosion and the formation and deposition of scale and iron oxide in aqueous systems, comprising adding to the system at least 0.1 ppm of a water-soluble polymer having an intrinsic viscosity of 0.05 to 2.5 dl/g, prepared from:(a) 35 to 90%, by weight, of an unsaturated carboxylic acid, or its salt;(b) 5 to 40%, by weight of an unsaturated sulfonic acid, or its salt; and(c) 5 to 40%, by weight, of an unsaturated, polyalkylene oxide compound, the total of (a), (b) and (c) being 100% weight of the polymer.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: October 21, 1986
    Assignee: Calgon Corporation
    Inventors: Charles Y. Cha, Richard G. Varsanik, Shih-Ruey T. Chen
  • Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
    Patent number: 4617301
    Abstract: Sulfoxide and sulfone derivatives of bicyclic lactams are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: October 14, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Matthew J. Wyvratt, Jr.
  • Pharmaceutical compositions of 4-(dibenzo-[a,d]cycloalkenyl)piperazine compounds and methods
    Patent number: 4616023
    Abstract: Pharmaceutical compositions comprising 4-(dibenzo[a,d]cycloalkenyl)piperazine compounds and the use of said piperazine compounds for treatment of certain cardiovascular disorders are disclosed.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: October 7, 1986
    Assignee: Merck & Co., Inc.
    Inventors: David C. Remy, Steven D. Young
  • Aminohydroxypropoxy substituted aryl compounds
    Patent number: 4616017
    Abstract: Novel tertiary aminohydroxypropoxy substituted aryl compounds exhibit .alpha..sub.1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: October 7, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Mercapthothiazoline corrosion inhibiting compositions
    Patent number: 4613481
    Abstract: The present invention is directed to a composition useful for inhibiting the corrosion of copper and copper alloy metals in an aqueous system comprising mercaptothiazoline and ferrous ions.The present invention is also directed to a method of inhibiting the corrosion of copper and copper alloy metals in an aqueous system comprising maintaining in the aqueous system at least about 1 ppm (parts per million) of mercaptothiazoline, preferably in combination with ferrous ions.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: September 23, 1986
    Assignee: Calgon Corporation
    Inventors: Jasbir S. Gill, Arthur J. Friedman
  • Admixtures of 2-bromo-2-bromomethylglutaronitrile and methylene bis(thiocyanate)
    Patent number: 4612328
    Abstract: The instant invention is directed to synergistic antimicrobial admixtures comprising 2-bromo-2-bromomethylglutaronitrile and methylene bis(thiocyanate) and its use in inhibiting microbial growth.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: September 16, 1986
    Assignee: Calgon Corporation
    Inventor: John A. Jakubowski