Patents Represented by Attorney Michael C. Sudol
  • Patent number: 4673680
    Abstract: Selective .alpha..sub.2 -adrenergic receptor antagonists are effective in modifying gastrointestinal motility in a manner useful in the treatment of colonic spasm, irritable bowel syndrome and constipation.
    Type: Grant
    Filed: September 18, 1985
    Date of Patent: June 16, 1987
    Inventor: Robert G. Pendleton
  • Patent number: 4670443
    Abstract: Benzo(f)isoquinoline compounds, particularly, penta- and tetrahydrobenzo(f)isoquinoline dicarboxylic acid compounds, their preparation and their use as calcium entry blockers are disclosed.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: June 2, 1987
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Brian T. Phillips
  • Patent number: 4668697
    Abstract: Novel 2-sulfamoylbenzo[b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: May 26, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, Samuel L. Graham
  • Patent number: 4668696
    Abstract: There is disclosed a macrolide isolated from the fermentation broth, with 22,23-dihydro avermectin Bla aglycone as a substrate, of a known microorganism identified as MA-5853. The structure of the novel compound isolated from the microorganism is presented based upon analytical studies. The compound is a highly potent antiparasitic, insecticidal, and anthelmintic agent. Compositions for such uses are also disclosed.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: May 26, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Raymond F. White, Edward S. Inamine
  • Patent number: 4666937
    Abstract: There are disclosed novel compounds which are derived from 22,23-dihydro avermectin Bla aglycone, 13-deoxy-22,23 dihydro overmectin Bla aglycone and 13-deoxy-22,23-dihydro overmectin Blb aglycone. The six compounds are hydroxy adducts of the substrate avermectin compound at the 12a, 24, 24a, 26, 26a and 27 positions. The hydroxy adducts are prepared by incubating the substrate with the microorganism Cunninghamella blakesleeana and isolating the hydroxy adducts from the fermentation broth. The compounds are highly potent antiparasitic, insecticidal and anthelmintic agents.
    Type: Grant
    Filed: February 20, 1986
    Date of Patent: May 19, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Edward S. Inamine, Raymond F. White
  • Patent number: 4666901
    Abstract: Substituted lactams and related compounds and methods for their preparation are disclosed. These compounds are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: May 19, 1987
    Assignee: Merck & Co., Inc.
    Inventor: William H. Parsons
  • Patent number: 4665090
    Abstract: Thiophene-2-sulfonamides with a 5-alkyl-substituent are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: May 12, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Samuel L. Graham
  • Patent number: 4665094
    Abstract: Hydroxyalkyl-phenoxy-propan-2-olamines and novel esters thereof are oculoselective .beta.-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: May 12, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4665091
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## are disclosed. Also disclosed are pharmaceutical compositions and methods of use of the compounds of formula (I).
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: May 12, 1987
    Assignee: Merck & Co., Inc.
    Inventor: William F. Hoffman
  • Patent number: 4663344
    Abstract: 3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of 2-(2-carboxy-phenylthio)-.alpha.-substituted acetic acids. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory diseases and other prostaglandin and/or leukotriene mediated diseases.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: May 5, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Bruce E. Witzel, Kathleen M. Rupprecht, Allan N. Tischler, Timothy F. Gallagher
  • Patent number: 4663349
    Abstract: The invention relates to compositions and methods of enhancing rectal absorption of L-dopa via the formation of an ester prodrug and optionally with a decarboxylase inhibitor.
    Type: Grant
    Filed: December 30, 1985
    Date of Patent: May 5, 1987
    Assignee: Merck & Co., Inc.
    Inventor: A. J. Repta
  • Patent number: 4661483
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: April 28, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Clarence S. Rooney, Ta J. Lee
  • Patent number: 4655815
    Abstract: The present invention is directed to a synergistic antimicrobial admixture comprising 2-bromo-2-bromomethylglutaronitrile and a formaldehyde donor.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: April 7, 1987
    Assignee: Calgon Corporation
    Inventor: John A. Jakubowski
  • Patent number: 4656168
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 13, 1983
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Patent number: 4656188
    Abstract: Angiotensin converting enzyme inhibitors are useful in the treatment of senile macular degeneration.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, John J. Baldwin
  • Patent number: 4654433
    Abstract: A simple single step process for preparing alkyl and substituted alkyl esters of amino acids is described. The products are bioactive compounds including compounds useful as antihypertensive agents.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: March 31, 1987
    Assignee: Merck & Co., Inc.
    Inventor: David L. Hughes
  • Patent number: 4654363
    Abstract: Certain 6-(substituted-naphthyl)hydrocarbyl-4-hydroxytetrahydropyran-2-ones are unexpectedly potent in the treatment of familial hypercholesterolemia, hyperlipemia and atherosclerosis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase).
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: March 31, 1987
    Assignee: Merck & Co., Inc.
    Inventor: John D. Prugh
  • Patent number: 4645854
    Abstract: A stereoselective process for the preparation of antihypercholesterolemic agents of the HMG-CoA reductase inhibitor type comprises treatment of an intermediate .beta.-hydroxyketone with a trialkylborane and sodium borohydride at low temperatures.
    Type: Grant
    Filed: April 25, 1985
    Date of Patent: February 24, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Verhoeven, James M. McNamara, Meyer Sletzinger
  • Patent number: 4642311
    Abstract: Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: February 10, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4640793
    Abstract: The instant invention is directed to an admixture, and its use in inhibiting scale and corrosion in aqueous systems, comprising:(a) a water-soluble polymer having a weight average molecular weight of less than 25,000, as determined by low angle laser light scattering, comprising an unsaturated carboxylic acid and an unsaturated sulfonic acid, or their salts, having a ratio of 1:20 to 20:1, and(b) at least one compound selected from the group consisting of water-soluble polycarboxylates, phosphonates, phosphates, polyphosphates, metal salts and sulfonates.The instant invention is also directed to a method of inhibiting the formation of insoluble alluvial, metal oxide and metal hydroxide deposits in an aqueous system, comprising adding to the system at least 0.
    Type: Grant
    Filed: May 9, 1985
    Date of Patent: February 3, 1987
    Assignee: Calgon Corporation
    Inventors: Leonard J. Persinski, Jerry L. Walker, Bennett P. Boffardi