Patents Represented by Attorney Michael P. Morris

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  • Alkyl-and piperidine-substituted benzimidazole derivatives
    Patent number: 7723360
    Abstract: A compound of general formula 1a wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 28, 2005
    Date of Patent: May 25, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Domnic Martyres, Franz Birke, Thierry Bouyssou
  • Compounds for the treatment of inflammatory diseases
    Patent number: 7723381
    Abstract: Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: May 25, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Horst Dollinger, Rolf Goeggel, Birgit Jung, Joerg Kley, Juergen Mack, Peter Nickolaus, Rainer Walter
  • PRRSV subunit vaccines
    Patent number: 7722878
    Abstract: Vaccines effective against PRRSV include at least one portion of PRRSV ORF1. Such vaccines, upon administration, provoke an immune response in PRRSV-susceptible animals. Moreover, compositions in accordance with the present invention provide immune response up to and including protective immunity against PRRSV as well as reduce the severity of PRRSV and/or incidence of PRRSV. Selected portions of ORF1 can be used singularly, in combination with one another, in combination with other PRRSV ORFs, and in combination with other PRRSV vaccines.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: May 25, 2010
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Eric M. Vaughn, Richard Stammer
  • Substituted pteridines for the treatment of inflammatory diseases
    Patent number: 7718654
    Abstract: The invention relates to new pteridine compounds of formula 1 wherein R1, R2 , R3 and R4 have the meanings given herein, which are useful for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers. The invention further relates to pharmaceutical compositions which contain these compounds.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: May 18, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Domnic Martyres, Horst Dollinger, Birgit Jung, Peter Nickolaus
  • Substituted 1,2-ethylenediamines, methods for preparing them and uses thereof
    Patent number: 7713961
    Abstract: The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1—X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Eickmeier, Stefan Peters, Klaus Fuchs, Niklas Heine, Sandra Handschuh, Cornelia Dorner-Ciossek, Klaus Klinder, Marcus Kostka
  • Substituted pyrrolidinones and their use as medicaments
    Patent number: 7714000
    Abstract: The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Kai Gerlach, Henning Priepke, Roland Pfau, Georg Dahmann, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar
  • Pyrrolobenzimidazolones and their use as anti-proliferative agents
    Patent number: 7714010
    Abstract: The invention relates to pyrrolobenzimidazolone compounds of formula (I), wherein A, T and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Darryl McConnel, Steffen Steurer, Bernd Krist, Ulrike Weyer-Czernilofsky, Maria Impagnatiello, Matthias Treu, Iris Kauffmann-Hefner, Pilar Garin-Chesa, Andreas Schnapp
  • Crystalline form of 1-chloro-4-(?-D-glucopyranos-1-yl)-2-[4-(()-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
    Patent number: 7713938
    Abstract: The invention relates to a crystalline form of 1-chloro-4-(?-D-glucopyranos-1-yl)-2-[4-((S) -tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Sandra Schmid, Martin Schuehle, Hans-Jürgen Martin, Matthias Eckhardt
  • Process for making heteroaryl amine intermediate compounds
    Patent number: 7714127
    Abstract: Disclosed are processes to produce a compound of the formula (I):
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui (Bruce) Lu, Ming Shen, Sonia Rodriguez, Vittorio Farina
  • Dry powder inhaler
    Patent number: 7708011
    Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: May 4, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH and Co. KG
    Inventors: Dieter Hochrainer, Joerg Schiewe, Bernd Zierenberg, Stephen Dunne
  • Enantiomerically pure beta agonists, manufacturing and use thereof
    Patent number: 7709474
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R1, R2, R3, m and Ym? may have the meanings given in the claims and specification, processes for preparing them and their use as medicaments, particularly as medicaments for the treatment of respiratory complaints.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: May 4, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ingo Konetzki, Peter Sieger
  • Pyrimidine derivatives
    Patent number: 7709480
    Abstract: The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 4, 2010
    Assignees: Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Georg Dahmann, Frank Himmelsbach, Bernd Krist, Martin Lenter, Alexander Pautsch, Gisela Schapp, Martin Steegmaier, Helmut Wittneben, Anthony S. Prokopowicz, Walter Spevak, Andreas Schoop, Steffen Steurer
  • Hepatitis C inhibitor peptide analogs
    Patent number: 7705146
    Abstract: The invention relates to compounds of formula (I) wherein R?, R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: April 27, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Murray D. Bailey, Punit Bhardwaj, Pasquale Forgione, Elise Ghiro, Nathalie Goudreau, Teddy Halmos, Montse Llinas-Brunet, Marc-Andre Poupart, Jean Rancourt
  • 1,6 Naphthridines useful as inhibitors of SYK kinase
    Patent number: 7705151
    Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: April 27, 2010
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, Scott E. Jakes, Joachim Heider, Mark A. Bobko, Renee L. Des Jarlais, Mark Player, James Rinker, Michael Winters, Bao-ping Zhao
  • CGRP antagonists
    Patent number: 7700589
    Abstract: CGRP antagonists of the formula of which the following are exemplary: (1) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide, (2) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-amide.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Eckhart Bauer, Marcus Schindler, Kirsten Arndt, Henri Doods
  • Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
    Patent number: 7700598
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stephan Georg Mueller, Klaus Rudolf, Philipp Lustenberger, Dirk Stenkamp, Alexander Dreyer, Kirsten Arndt, Henri Doods, Gerhard Schaenzle, Marco Santagostino, Fabio Paleari
  • Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge
    Patent number: 7699052
    Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen
  • PCV2 immunogenic compositions and methods of producing such compositions
    Patent number: 7700285
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • Dihydropteridione derivatives, process for their manufacture and their use as medicament
    Patent number: 7700769
    Abstract: Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Grauert, Matthias Hoffmann
  • Hepatitis C inhibitor peptide analogs
    Patent number: 7696242
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: April 13, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Murray D. Bailey, Punit Bhardwaj, Elise Ghiro, Nathalie Goudreau, Teddy Halmos, Montse Llinas-Brunet, Marc-André Poupart, Jean Rancourt