Patents Represented by Attorney Michael P. Morris

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  • Pathogen for bacterial poultry disease
    Patent number: 7794735
    Abstract: The invention belongs to the field of animal health and in particular the causative agent of a new bacterial poultry disease, Gallibacterium. The invention provides said Gallibacterium bacteria, vaccine comprising inactivated Gallibacterium, and a method of immunizing to prevent disease in poultry.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: September 14, 2010
    Assignee: Boehringer Ingelheim Vetmedica S.A. DE C.V.
    Inventors: Raul Campogarrido, Carlos Gonzalez-Hernandez, Vaithianathan Sivanandan, Maria Elena Vazquez
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
    Patent number: 7795272
    Abstract: Compounds of Formula (IA) and Formula (IB) where in R1 stands for the following group (the dashed line indicates the point of attachment) and R2, R3, R4, R5, R6, Y, Z, X1 and X2 are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: September 14, 2010
    Assignee: Boehringer Ingelheim Pharmaceutical, Inc.
    Inventors: Thomas Martin Kirrane, Jr., Daniel Kuzmich, John Robert Proudfoot
  • Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
    Patent number: 7790712
    Abstract: The application relates to compounds of formula Ia and analogues thereof wherein R1 to R13 and X are as defined herein. The invention also relates to the use of the compounds of formula Ia as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: September 7, 2010
    Assignee: Boehringer Ingelheim Pharmaceutical, Inc.
    Inventors: Derek Cogan, Donghong A. Gao, Daniel R. Goldberg, Craig Andrew Miller, Neil Moss, Matthew Russell Netherton, Philip Dean Ramsden, Zhaoming Xiong
  • Medicaments for the treatment of chronic obstructive pulmonary disease
    Patent number: 7786111
    Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: August 31, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Klaus Rudolf, Philipp Lustenberger, Christoph Hoenke
  • Methods for treating diseases or conditions using dihydropteridinone compounds
    Patent number: 7786299
    Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: August 31, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Hoffmann, Matthias Grauert, Martin Steegmaier, Anke Baum, Jens Jurgen Quant, Flavio Solca, Florian Colbatzky
  • Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
    Patent number: 7776830
    Abstract: Glucopyranosyl-substituted benzonitrile derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Grant
    Filed: May 1, 2007
    Date of Patent: August 17, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Achim Sauer, Leo Thomas
  • Pharmaceutical compositions based on anticholinergics and additional active ingredients
    Patent number: 7776315
    Abstract: A pharmaceutical composition comprising an anticholinergic and at least one additional active ingredient selected from among corticosteroids, dopamine agonistes, PDE-IV inhibitors, NK1-antagonists, endothelin antagonists, antihistamines, and EGFR-kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: August 17, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Michel Pairet, Michael P. Pieper, Christopher John Montague Meade, Richard Reichl, Christel Schmelzer, Birgit Jung
  • Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Patent number: 7772378
    Abstract: Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: August 10, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Peter Eickelmann, Leo Thomas, Edward Leon Barsoumian
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
    Patent number: 7772191
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: August 10, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhengxu Han
  • Hepatitis C inhibitor dipeptide analogs
    Patent number: 7767818
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: August 3, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Murray Douglas Bailey, Elise Ghiro, Nathalie Goudreau, Teddy Halmos, Montse Llinas-Brunet, Marc-Andre Poupart, Jean Rancourt
  • Tiotropium containing powder formulation for inhalation
    Patent number: 7763280
    Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: July 27, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Mareke Hartig, Michael Trunk, Michael Walz
  • of european origin and vaccines, diagnostic agents and methods of use thereof
    Patent number: 7758870
    Abstract: The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Michael B. Roof, Jeremy J. Kroll, Jeffrey P. Knittel
  • Pharmaceutical blister
    Patent number: 7758936
    Abstract: The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water vapor and organic molecules.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Michael Spallek, Burkhard Metzger
  • Method for detection of nitric oxide (NO)
    Patent number: 7759054
    Abstract: The present invention relates to methods for detection of nitric oxide (NO) by measuring guanosine monophosphate (cGMP).
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Frank Buettner
  • 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments
    Patent number: 7759347
    Abstract: The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Hoffmann, Matthias Grauert, Thorsten Lehmann-Lintz, Martin Steegmaier, Flavio Solca, Norbert Redemann
  • Piperidine-substituted indoles
    Patent number: 7759365
    Abstract: Disclosed are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula 1: wherein R1, R5, R6, R7, A, B, D-E, Y, i, j, n and m are defined as below. The compounds of formula 1 are useful as agonists or antagonists of CCR-3. The present invention is also directed to pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Domnic Martyres, Pascale Pouzet, Christoph Hoenke, Peter Seither, Silke Hobbie, Thierry Bouyssou
  • Process for the manufacture of dihydropteridinones
    Patent number: 7759485
    Abstract: Disclosed are processes for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Gerd F. Kraemer, Ludwig Gutschera, Geert Asche
  • Keratinocytes useful for the treatment of wounds
    Patent number: 7754481
    Abstract: The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 13, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Petra Eberhardt, Wolfgang Noe, Katharina Reif
  • Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7754756
    Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: July 13, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rainer Walter, Bradford S. Hamilton, Thomas Trieselmann, Matthew R. Netherton, Marco Santagostino, Ingo Konetzki
  • Substituted pteridines for the treatment of inflammatory diseases
    Patent number: 7750009
    Abstract: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: July 6, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Horst Dollinger, Juergen Mack, Domnic Martyres, Birgit Jung, Peter Nickolaus