Patents Represented by Law Firm Millen, Raptes & White
  • Indolylacetylamino acid derivatives, process for their preparation, and pharmaceutical compositions
    Patent number: 3962471
    Abstract: Indolylacetylamino acids of the formula ##SPC1##Wherein R is H or CH.sub.3, physiologically acceptable salts thereof and the corresponding amides, alkyl and benzyl esters and alkyl and benzyl ethers thereof, possess anti-inflammatory activity.
    Type: Grant
    Filed: March 12, 1975
    Date of Patent: June 8, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Biere, Hanns Ahrens, Clemens Rufer, Eberhard Schroder, Henning Koch
  • Novel pyrazolyloxyacetic acid derivatives and process for the preparation thereof
    Patent number: 3962453
    Abstract: Compounds of the formula ##SPC1##Wherein X and Y each are a bond or methylene, R is H or lower-alkyl and Z is a carboxyl, amide, nitrile or alkoxycarbonyl of 1-6 carbon atoms in the alkoxy group and the corresponding compounds bearing 1-2 halogen, lower-alkyl or lower-alkoxy groups on one or both benzene rings and, when Z is carboxyl, salts thereof with physiologically acceptable bases, possess anti-inflammatory and antipyretic activities.
    Type: Grant
    Filed: September 12, 1974
    Date of Patent: June 8, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Hans Ahrens, Helmut Biere, Clemens Rufer, Eberhard Schroder, Henning Koch
  • Process for selectively producing paraxylene
    Patent number: 3962363
    Abstract: Process for selectively producing paraxylene comprising reacting toluene with methanol, dimethylether or vinyl chloride and at least one polymethylbenzene having 4 to 6 methyl groups or a condensed polymethylaromatic compound or a complex containing the same, in the presence, as catalyst, of a zeolite whose pore diameter is at least 7.5 A.
    Type: Grant
    Filed: September 25, 1974
    Date of Patent: June 8, 1976
    Assignee: Institut Francais du Petrole des Carburants et Lubrifiants
    Inventors: Albert Mabille, Inaki DE Aguirre, Christian Marcilly
  • Process for purifying industrial gases containing hydrogen sulfide with sulfur production
    Patent number: 3962410
    Abstract: Process for purifying industrial gases containing hydrogen sulfide and for simultaneously producing elemental sulfur, comprising contacting said gases with an aqueous solution of sodium hydroxide and/or sodium carbonate, thereby forming a sodium sulfide solution, contacting said solution with an aqueous solution of ammonium hydrogen carbonate or with a gaseous mixture of CO.sub.2 and NH.sub.3 so as to precipitate sodium hydrogen carbonate, decomposing the latter to CO.sub.2 and neutral sodium carbonate which is recycled, heating the resulting liquid phase to produce NH.sub.3 and H.sub.2 S and producing sulfur by reacting the H.sub.2 S with sulfurous anhydride.
    Type: Grant
    Filed: November 19, 1973
    Date of Patent: June 8, 1976
    Assignee: Institut Francais du Petrole, des Carburants et Lubrifiants
    Inventors: Philippe Renault, Andre Deschamps, Claude Dezael
  • Process for the preparation of 17.beta.-oxalyl steroids
    Patent number: 3960842
    Abstract: 20-Cyano-17.alpha.-H steroids having as the 17-position substituent the group ##EQU1## wherein R is H, alkyl of 1-8 carbon atoms or benzyl, having a 13-methyl or 13-ethyl group and which are unsubstituted or substituted with an .alpha.-methyl group in the 16-position are converted to the corresponding 20-keto steroids by reaction in an aprotic solvent with a deprotonating agent containing an alkali metal, an alkaline earth metal, copper(I) or thallium(I), and optionally additionally with a copper(I) salt or a thallium(I) salt or a silver(I) salt, and thereafter conducting an oxidative splitting reaction with oxygen. The thus-produced 17.beta.-oxalyl steroids possess pharmacological activity, e.g., anti-inflammatory activity, or are useful as intermediates for the production of pharmacologically active steroids.
    Type: Grant
    Filed: July 12, 1974
    Date of Patent: June 1, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Ulrich Eder, Henry Laurent, Jurgen Ruppert, Gerhard Sauer, Rudolf Wiechert
  • 3,17,18-Trihydroxy-1,3,5(10)-estratrienes
    Patent number: 3960841
    Abstract: 3,17,18-Trihydroxy-1,3,5(10)-estratrienes of the formula ##SPC1##Wherein R is H or substituted or unsubstituted saturated or unsaturated hydrocarbon, and esters and ethers thereof, possess strong vaginotropic and only weak utertropic activity and are useful in the treatment of estrogenic deficiency conditions where uteral effects are not desired.
    Type: Grant
    Filed: July 12, 1974
    Date of Patent: June 1, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Klaus Engel, Klaus Prezewowsky, Henry Laurent, Yukishige Nishino
  • 1,2-Biguanides
    Patent number: 3960949
    Abstract: 1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.
    Type: Grant
    Filed: July 9, 1974
    Date of Patent: June 1, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Hanns Ahrens, Clemens Rufer, Helmut Biere, Eberhard Schroder, Wolfgang Losert, Olaf Loge, Ekkehard Schillinger
  • Arsenic pentoxide glasses
    Patent number: 3960578
    Abstract: Arsenic pentoxide glasses characterized by containing 8 - 60 wt.% arsenic pentoxide and correspondingly 92 - 40 wt.% polyvalent metal fluorides exhibit improved processing characteristics while maintaining outstanding optical properties when prepared from a formula containing at least 0.5% of at least one member selected from the group consisting of bromides, chlorides, sulfates and metal oxides.
    Type: Grant
    Filed: January 19, 1973
    Date of Patent: June 1, 1976
    Assignee: Jenaer Glaswerk Schott & Gen.
    Inventor: Georg Krolla
  • Swab applicator
    Patent number: 3958571
    Abstract: The invention relates to a swab applicator which comprises an elongated hollow tube open at one end, normally closed at the opposite end, and containing a solution such as a medicament. A swab of absorbent material is secured around the open end, and the opposite end is provided with means to open the end to permit the solution to flow by gravity into said swab.
    Type: Grant
    Filed: August 22, 1973
    Date of Patent: May 25, 1976
    Inventor: William E. Bennington
  • Process for the production of crystalline propene-ethene-butene-1 terpolymers
    Patent number: 3959409
    Abstract: In a low pressure process for the production of crystalline propene-ethene-butene-1 terpolymers with 0.2 to 10% by weight of ethene and 0.2 to 5% by weight of butene-1 with the aid of mixed catalysts of TiCl.sub.3 or TiCl.sub.3 .sup.. n AlCl.sub.3 (n = 0.2 to 0.6), and chlorine-containing organoaluminum compounds, the improvement comprising conducting the polymerization in butene-2 or in a C.sub.4 -cut containing 20-99% butene-2, containing 0.1 - 2.5% of butene-1, with the addition of 0.2 to 10% of ethene, based on the amount of propene employed.
    Type: Grant
    Filed: October 16, 1974
    Date of Patent: May 25, 1976
    Assignee: Chemische Werke Huls Aktiengesellschaft
    Inventors: Albert Frese, Fritz Baxmann, Walter Dittmann, Johann Dietrich
  • Lubricating oil compositions containing hydrogenated polybutadiene viscosity index improvers
    Patent number: 3959161
    Abstract: A lubricating oil composition having an improved viscosity index is manufactured by admixing lubricating oil in major proportion with a butadiene polymer in minor proportion, said polybutadiene having a molecular weight of at least 20,000 and a microstructure of from 65 to 85 % ##EQU1## units, from 2 to 35 % of -- CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- units and from 0 to 25 % of -- CH.sub.2 --CH = CH--CH.sub.2 -- units.
    Type: Grant
    Filed: February 21, 1974
    Date of Patent: May 25, 1976
    Assignee: Institut Francais du Petrole, des Carburants et Lubrifiants
    Inventors: Francois Dawans, Emmanuel Goldenberg, Jean-Pierre Durand
  • Carrier matrix for the fixation of biochemically effective substances and process for the preparation thereof
    Patent number: 3959080
    Abstract: Biochemically active compounds e.g., proteins and particulate biological materials such as bacteria and viruses, are immobilized on a water-swellable or water-insoluble matrix by covalent bonding to a partially crosslinked polymer containing reactive groups capable of binding the biochemically active compound thereto.
    Type: Grant
    Filed: September 26, 1973
    Date of Patent: May 25, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans Dieter Orth, Wolfgang Brummer, Michael Klockow, Norbert Hennrich
  • Water-soluble hydroxyalkylated and alkoxyalkylated compositions and the like derived from N-3-oxohydrocarbon-substituted acrylamides, and polymers thereof
    Patent number: 3959224
    Abstract: N-3-Oxohydrocarbon-substituted acrylamides, especially diacetone acrylamide, react with aldehydes in alkaline media (usually aqueous) to form water-soluble compositions which contain hydroxyalkylated and/or alkoxyalkylated derivatives of said substituted acrylamides. Addition polymers of these water-soluble compositions may be prepared, especially as aqueous latices or as solutions in organic solvents. These addition polymers are useful in adhesives and coatings. In particular, the polymers may be combined with pigments and/or with alkaline reagents or aminoplast compositions to form paints and textile adhesives.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: May 25, 1976
    Assignee: The Lubrizol Corporation
    Inventor: Lester Earl Coleman
  • Catalyst for hydrocarbon conversion
    Patent number: 3957686
    Abstract: New catalyst containing a carrier, platinum, iridium, manganese and optionally halogen. This catalyst is useful for reforming and dehydrogenation of hydrocarbons.
    Type: Grant
    Filed: December 13, 1973
    Date of Patent: May 18, 1976
    Assignee: Societe Francaise des produits pour Catalyse
    Inventors: Pierre Duhaut, Germain Martino, Jean Miquel
  • Method for contraception by the application of combination-type sequential preparations
    Patent number: 3957982
    Abstract: Method of contraception in which an estrogen and a progestagen are orally administered daily for 21 days, the first 4-6 days at a low contraceptively effective daily dose, the next 4-6 days at a daily estrogen dose 1-2 times and a daily progestrogen dose 1-1.5 times that of the first 4-6 days, and for the next 9-11 days at a daily estrogen dose from that of the first 4-6 days to that of the next 4-6 days and a daily progestogen dose higher than either prior daily dose, up to 3 times that of the initial dose, followed by 7 days without hormone administration.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: May 18, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Ursula Lachnit-Fixson, Alan G. Pitchford
  • 2-Methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid 1-methyl-4-piperidyl ester
    Patent number: 3956334
    Abstract: Piperidines of the formula ##SPC1##Wherein R is --CH.sub.2 OH, CO--NR,R.sub.2 in which R.sub.1 and R.sub.2 each are H or alkyl of 1-4 carbon atoms, --NHCH.sub.2 CH.sub.2 OH, --N(CH.sub.2 CH.sub.2 OH).sub.2, --NHCH.sub.2 CH.sub.2 SO.sub.3 H, --NHNH.sub.2 or --NHCH.sub.2 COOH, or --COOR.sub.3 in which R.sub.3 is 3-pyridylmethyl, 2-acetamidoethyl, 1-methyl-4-piperidyl or 2,3-dihydroxypropyl and the physiologically acceptable salts thereof, have cholesterol-level-lowering and triglyceride-level-lowering activity and can be prepared from 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid or a functional derivative thereof by reduction or by reaction with a compound of the formula HZ.
    Type: Grant
    Filed: June 26, 1974
    Date of Patent: May 11, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane
  • Carbazole derivatives
    Patent number: 3956295
    Abstract: Carbazoles of the formula ##SPC1##Wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.
    Type: Grant
    Filed: July 17, 1974
    Date of Patent: May 11, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Biere, Hanns Ahrens, Clemens Rufer, Eberhard Schroder, Henning Koch
  • Process and quick-action reagent for the detection of narcotics
    Patent number: 3955926
    Abstract: A quick-action reagent for the detection of narcotics comprising a solvent for the narcotic and a color reagent, at least one component of which is impregnated in an absorbent substrate.
    Type: Grant
    Filed: February 12, 1973
    Date of Patent: May 11, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventor: Wolfgang Fischer
  • Process for the chemical modification of surfaces of inorganic solids
    Patent number: 3956179
    Abstract: A process for the chemical modification of the surfaces of inorganic solid bodies containing --OH groups, which comprises silanizing the free --OH groups with an alkylhalosilane to covalently bond the alkyl groups thereof to the oxygen atoms of the hydroxyl groups; halogenating or sulfochlorinating the resultant bound alkyl groups to form corresponding haloalkyl or sulfochloroalkyl groups; and replacing the halogen atoms of the resultant haloalkyl or sulfochloroalkyl groups by substitution with a functional group to form a chemically modified, inorganic solid body suitable for use as a stationary phase component in catalysis or chromatography.
    Type: Grant
    Filed: March 15, 1974
    Date of Patent: May 11, 1976
    Assignee: Istvan Helsaz
    Inventors: Imrich Sebestian, Istvan Halasz
  • Steroid ether splitting
    Patent number: 3956348
    Abstract: Ethers of aromatic steroids are cleaved to regenerate the hydroxy group with aluminum hydride, dialkylaluminum hydride or trialkylaluminum.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: May 11, 1976
    Assignee: Schering Aktiengesellschaft
    Inventor: Jean-Claude Hilscher