Patents Represented by Law Firm Millen, Raptes & White
  • Phenoxypropionic acid derivatives
    Patent number: 3968143
    Abstract: Phenoxypropionic acid derivatives of the formula ##SPC1##Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2##With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: July 6, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Gunter Lauterbach, Werner Mehrhof, Herbert Nowak, Zdenek Simane
  • Process for the separation of a gaseous mixture consisting of water vapor, hydrocarbons, and air
    Patent number: 3967938
    Abstract: In the dispensing of gasoline into a tank used for the storage or transportation of gasoline wherein the gasoline displaces a gaseous mixture of air and gasoline, and said mixture is treated to a recovery step to separate said gasoline from said mixture, there is provided an improvement in the recovery step which comprises cooling said mixture to condense out the gasoline and water from the air thereby purifying the air, and then separating the water from the gasoline. One or two main heat exchangers can be employed depending on whether the system is operated continuously or not. A short regeneration time is made possible by the use of steam which expands the heat exchange tubes sufficiently to remove ice cleanly. An absorber using activated carbon is optionally employed in addition to the removal of the gasoline by cooling.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: July 6, 1976
    Assignee: Linde Aktiengesellschaft
    Inventors: Werner Daeschler, Hans-Jakob Finkenauer, Gerhard Frey, Hans Rainer, Walter Schramm
  • Process for the production of pure cyclopentene
    Patent number: 3968180
    Abstract: A process for the production of cyclopentene free of C.sub.5 -diene impurities, which comprises metathetically reacting cis,cis-cyclodecadiene-(1,6) with a catalytic amount of a metathesis catalyst comprising a support material and an oxide of an element of Group VI A or VII A of the Periodic Table, at a reaction temperature of from 0.degree.C up to the temperature at which said catalyst decomposes, for a period of time sufficient to form said cyclopentene.
    Type: Grant
    Filed: October 22, 1974
    Date of Patent: July 6, 1976
    Assignee: Chemische Werke Huls Aktiengesellchaft
    Inventors: Friedrich-Wilhelm Kupper, Roland Streck
  • Prevention of wall deposits during polyvinyl chloride polymerizations
    Patent number: 3966695
    Abstract: The formation of polymer on the surfaces of the reactor equipment in the commercial production of polyvinyl chloride and copolymers thereof is avoided by employing equipment whose surfaces which contact the monomer are formed of substantially pure nickel.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: June 29, 1976
    Assignee: Chemische Werke Huls Aktiengesellschaft
    Inventors: Karsten Flatau, Bernd Terwiesch
  • Process for hydrodealkylating alkylaromatic hydrocarbons
    Patent number: 3966833
    Abstract: Process for hydrodealkylating an alkylaromatic hydrocarbon charge at a temperature from 400.degree. to 650.degree.C under a pressure from 1 to 30 kg/cm.sup.2 at a space velocity from 1 to 10 by reacting said charge with hydrogen in a molar proportion with respect to the effluent of the reactor in the range from 1 to 10, in the presence of a catalyst containing alumina and at least one metal selected from ruthenium, osmium, palladium, rhodium, iridium, platinum and manganese in an amount from 0.05 to 5 % of the catalyst, said catalyst having a specific surface from 1 to 100 m.sup.2 /g., a total pore volume of 0.2-0.8 g/cc and a heat of neutralization lower than 10 calories per gram are measured by ammonia adsorption at 320.degree. C. under 300 mm Hg.
    Type: Grant
    Filed: December 13, 1974
    Date of Patent: June 29, 1976
    Assignee: Institut Francaise du Petrole, de Carburants et Lubrifiants
    Inventors: Jean Cosyns, Bernard Juguin, Jean-Francois Le Page, Jean Miquel
  • Light conducting fibers of quartz glass
    Patent number: 3966300
    Abstract: Light-conducting optical fibers in which both the core and sheath consist essentially of quartz glass are provided by encasing a relatively anhydrous quartz glass core with a quartz glass sheath having a sufficiently high water content to lower the refractive index thereof. The fibers are ideally suited for the transmission of ultraviolet light with maximum efficiency.
    Type: Grant
    Filed: January 22, 1973
    Date of Patent: June 29, 1976
    Assignee: Jenaer Glaswerk Schott & Gen.
    Inventor: Gerhard Bernsee
  • Nitroimidazolyl pyrimidines
    Patent number: 3966732
    Abstract: Nitroimidazolyl pyrimidines of the formula ##SPC1##And physiologically acceptable acid addition salts thereon wherein X is alkyl of 1-4 carbon atoms, R.sub.1 and R.sub.2 each are a hydrogen atom, alkyl of 1-4 carbon atoms, phenyl triflouromethyl or a monocyclic heterocyclic ring and R.sub.3 is a hydrogen atoms, alkyl of 1-4 carbon atoms, hydroxyalkoxy of 2-4 carbon atoms or an ester thereof of an alkanocarboxylic acid of 1-4 carbon atoms, oxoalkyl of 8-6 carbon atoms, or, when R.sub.1 or R.sub.2 is phenyl, alkylene having 1-2 carbon atoms in the chain joined to the 2-position of the phenyl ring possess trichomonicidal activity.
    Type: Grant
    Filed: April 14, 1975
    Date of Patent: June 29, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Clemens Rufer, Eberhard Schroder, Hans-Joachim Kessler
  • Process for producing citric acid by fermentation
    Patent number: 3966553
    Abstract: Process for manufacturing citric acid by aerobic culture of yeast strains in a medium containing at least one n-paraffin, comprising adding to the culture medium, after the phase of exponential growth thereof, a nitrogenous heterocyclic organic compound selected from .alpha.-picolinic acid, 2,6-dipicolinic acid, quinaldic acid, bi-pyridine, orthophenanthroline, 8-hydroxyquinoline and 5-hydroxyquinoxaline, at a concentration from 0.5 to 10 g/liter, and controlling the pH value of said medium during said growth phase by addition of sodium or potassium carbonate.
    Type: Grant
    Filed: December 6, 1973
    Date of Patent: June 29, 1976
    Assignee: Institut Francais du Petrole, des Carburants et Lubrifiants et Entreprise de Recherches et d'Activities Petrolieres Elf
    Inventors: Jean-Max Charpentier, Georges Glikmans, Paul Maldonado
  • Process for the preparation of a .DELTA..sup.4 -3-keto steroid 17-propiolactone
    Patent number: 3966714
    Abstract: 4-Androstene-3,17-dione and 1,4-androstadiene-3,17-dione are converted to 3-(17.beta.-hydroxy-4-androsten-3-on-17.alpha.-yl)-propionic acid lactone in three steps by reaction with propargyl alcohol in the presence of an alkali alcoholate of a tertiary alcohol, hydrogenating the thus-produced 17.alpha.-(3-hydroxy-propinyl)-17-.beta.-hydroxy compound with hydrogen in the presence of a complex metallic catalyst to produce 17.alpha.-(3-hydroxypropyl)-17.beta.-hydroxy-3-keto-androst-4-ene, which is oxidized with chromic acid to the desired lactone.
    Type: Grant
    Filed: May 23, 1974
    Date of Patent: June 29, 1976
    Assignee: Schering Aktiengesellschaft
    Inventor: Rainer Philippson
  • Process for manufacturing sulfur from a solution of sodium sulfite
    Patent number: 3966891
    Abstract: A solution of sodium sulfite or sulfide is reacted with ammonium sulfate, so as to produce a gas containing SO.sub.2 or H.sub.2 S, NH.sub.3 and H.sub.2 O, which is thereafter treated for sulfur production and NH.sub.3 recovery, and a liquid outflow containing sodium sulfate which is reacted with CO.sub.2 and NH.sub.3, in order to produce NaHCO.sub.3 and regenerate the ammonium sulfate. NaHCO.sub.3 may be converted to sodium carbonate and CO.sub.2, the latter being re-used in the process.
    Type: Grant
    Filed: October 15, 1973
    Date of Patent: June 29, 1976
    Assignee: Institut Francaise du Petrole, des Carburants et Lubrifiants
    Inventors: Philippe Renault, Andre Deschamps, Claude Dezael
  • Production of high-vinyl group, high-molecular weight unsaturated hydrocarbon polymers
    Patent number: 3966697
    Abstract: High molecular weight polybutadiene, polyisoprene and other hydrocarbon polymers having a high vinyl and a low 1,4-trans-double bond content, which are useful in the manufacture of tire treads and carcasses, are produced employing as catalyst system (a) a cobalt compound; (b) a halogen-containing organoaluminum compound; and (c) a tris-(aryl) phosphite of the formula P--(OR.sub.1), (--OR.sub.2),--OR.sub.3 wherein R.sub.1, R.sub.2 and R.sub.3 are monocyclic halogenated aryl, or diaryl, naphthyl, anthracenyl or phenanthryl or the corresponding halogenated and/or alkylated polycyclic aryl; and optionally (d) an H-acidic compound, e.g., water.
    Type: Grant
    Filed: December 9, 1974
    Date of Patent: June 29, 1976
    Assignee: Chemische Werke Huls Aktiengesellschaft
    Inventors: Wolfgang Kampf, Karl-Heinz Nordsiek
  • 11.beta.-FLUOROANDROSTENES
    Patent number: 3966713
    Abstract: 11.beta.-Fluoroandrostenes of the formula ##SPC1##Wherein R.sub.1 and R.sub.2 are hydrogen atoms, methylene or another C--C bond; R.sub.3 is H or Cl, R.sub.4 is H, F or Cl; and X is carbonyl, .beta.-hydroxymethylene, or an ester or ether thereof or .alpha.-alkyl-.beta.-hydroxymethylene or an ester thereof, possess androgenic activity and can be prepared by the dehalogenation of a corresponding 9.alpha.-halo-11.beta.-F steroid.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: June 29, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Hofmeister, Henry Laurent, Rudolf Wiechert, Klaus Annen, Hermann Steinbeck
  • Enzymatic determination of glucose
    Patent number: 3964974
    Abstract: Glucose is rapidly ad quantitatively determined with an analytical agent containing glucose dehydrogenase having an activity of at least 2 .mu./mg and NADH.sub.2 oxidase activity less than 0.1%, a pyridine coenzyme, a buffer and mutarotase to increase spontaneous mutarotation of alpha-glucose to beta-glucose. There may be optionally present inhibitors for reduced pyridine coenzyme oxidases and a thermal stabilizing amount of alkali metal chloride.
    Type: Grant
    Filed: September 10, 1973
    Date of Patent: June 22, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Dieter Banauch, Wolfgang Brummer, Wolfgang Ebeling, Roland Helger, Norbert Hennrich, Hermann Lang
  • Process for the purification of crude chenodeoxycholic acid
    Patent number: 3965131
    Abstract: Crude chenodeoxycholic acid is purified by subjecting an aqueous solution of an alkali salt thereof to continuous liquid-liquid extraction with a water-immiscible organic solvent until substantially all extractable impurities have been extracted. Crystalline pure free acid is obtained therefrom by acidification of the aqueous solution, extracting the free acid with organic solvent and thereafter removing the solvent, the last portion thereof preferably in the presence of water.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: June 22, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Dietrich Wiele, Jurgen Riemann
  • 6,9-Oxido-9,10-secoestrane derivatives and method of synthesis
    Patent number: 3965124
    Abstract: 6,9-Oxido-9,10-seco-1,3,5(10),6,8,14-estrahexaenes, useful as intermediates in the total synthesis of steroids, of the formula ##SPC1##Wherein n is 1 or 2, R.sub.1 is lower-alkyl, R.sub.2, R.sub.3 and R.sub.4 are H, alkoxy or acyloxy, X is a free or ketalized keto or free, esterified or etherified hydroxymethylene, are produced by the cyclization, with an acid catalyst, of a 9,10-secoestrane of the formula ##SPC2##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the values given above and Q is carbonyl or dialkoxymethylene. Hydrogenation produces the corresponding 6,9-oxido-9,10-seco-1,3,5(10)-estratrienes and 9-oxy-9,10-seco-1,3,5(10)-estratrienes.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: June 22, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Eder, Gregor Haffer, Jurgen Ruppert, Gerhard Sauer, Rudolf Wiechert
  • 4-Nitroperhydropyrido[1,2-a][1,4]diazepines
    Patent number: 3965103
    Abstract: Compounds of the formula v,2/12Wherein R.sub.1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH.sub.2) .sub.n --X wherein n is 0-4 and X is --COO-lower-alkyl, C.tbd.N or --COOH and R.sub.2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula ##SPC1##With a nitro compound of the formula R.sub.1 --CH.sub.2 --NO.sub.2 in the presence of formalin or paraformaldehyde, or with the R.sub.1 -- C(CH.sub.2 OH).sub.2 NO.sub.2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: June 22, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Biere, Hermann Ulbrich, Hans-Joachim Kessler, Ulrich Redmann
  • Production of bitumen compositions containing ethylene-.alpha.-olefin rubber
    Patent number: 3963659
    Abstract: Homogeneous thermoplastic bituminous compositions containing up to 25 parts by weight of ethylene-.alpha.-olefin rubber, e.g. ethylene-propylene rubber, saturated or unsaturated, exhibit improved properties for all asphalt applications, e.g. pipe coating, roads, roofing, etc. The compositions are produced by heating and agitating the bitumen and rubber at above 170.degree. C., preferably 180.degree.-240.degree. C., or by subjecting the rubber to premastication before admixture with the bitumen at lower temperatures. Cross-linkable rubbers can be cross-linked in the bituminous compositions to yield high tensile strength final products.
    Type: Grant
    Filed: April 25, 1975
    Date of Patent: June 15, 1976
    Assignee: Chemische Werke Huls Aktiengesellschaft
    Inventors: Gerhard Binder, Harald Blumel, Helmut Krol
  • Novel prostanoic acid derivatives and processes for the preparation thereof
    Patent number: 3962218
    Abstract: Prostaglandins of the formula ##SPC1##Wherein R.sub.1 is HOCH.sub.2, --COOH, a salt thereof or an ester thereof; R.sub.2 is OH; and R.sub.3 is H or R.sub.2 and R.sub.3 collectively are = O. A is --CH.sub. 2 --CH.sub.2 -- or --(trans)--CH=CH--, B is --CH.sub. 2 CH.sub.2 --or --(cis)--CH=CH-- and R.sub.4 --O--O--R.sub.5 is a ketal group, are superior in physiological activity to the corresponding 15-.alpha.-hydroxy-prostaglandins.
    Type: Grant
    Filed: May 23, 1974
    Date of Patent: June 8, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Bernd Raduchel, Werner Skuballa, Helmut Vorbruggen, Walter Elger, Wolfgang Losert, Olaf Loge
  • Process for preparing benzopyran derivatives
    Patent number: 3962280
    Abstract: Novel benzopyran derivatives of the formula ##SPC1##Wherein R.sub.1 and R.sub.3 each are lower alkyl; n is the integer 1 or 2; --A--B-- is >CH--CH.sub.2 -- or >CH=CH--; X is a free, esterified or etherified hydroxy group; and Y is H or X and Y collectively are =O; and W is --(CH.sub.2).sub.3 --Z--R.sub.4,--(ch.sub.2).sub.3 --coor.sub.6 or --(CH.sub.2).sub.3 CN, wherein V is halogen, Z is a ketalized carbonyl group R.sub.4 and R.sub.5 each are lower alkyl and R.sub.6 is alkyl, aryl or aralkyl, are valuable intermediates in the synthesis of steroids.
    Type: Grant
    Filed: June 6, 1973
    Date of Patent: June 8, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Eder, Gerhard Sauer, Gregor Haffer, Jurgen Ruppert, Rudolf Wiechert
  • Novel flame retardants and their production by chlorobromination of wood pulp waste liquors
    Patent number: 3962208
    Abstract: Novel chloro-brominated sulfurated lignin products obtained by chlorobromination of wood pulp waste liquors, having a total halogen content of from about 18 to about 40% by weight and a w:w Br:Cl ratio of from about 1:1 to about 5:1. The novel substances are used for flame proofing inflammable materials.
    Type: Grant
    Filed: February 10, 1975
    Date of Patent: June 8, 1976
    Assignee: The State of Israel, Ministry of Commerce & Industry
    Inventors: Esther Zeigerson, Moshe Rudolf Bloch