Patents Represented by Attorney Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  • Patent number: 8349827
    Abstract: The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: January 8, 2013
    Assignee: ArQule, Inc.
    Inventors: Manish Tandon, Yanbin Liu, Nivedita Namdev, Mark A. Ashwell, Rocio Palma
  • Patent number: 8349308
    Abstract: A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: January 8, 2013
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Carolina B. Cabral, Charles E. Hammond, Cheri A. Stevenson
  • Patent number: 8349555
    Abstract: The emerging concept of cancer stem cells suggests that activation in transformed cells of “stemness” genetic pathways (e.g., normal stem cells' self-renewal pathways) may contribute to the survival life cycle of cancer stem cells, and to tumor progression and metastasis of the malignancy. Thus, activation of “stemness” genes in cancer cells may be associated with aggressive clinical behavior and increased likelihood of therapy failure. General methods and kits associated with prediction of clinical outcome for a disease state of a subject based on gene expression analysis are described. The invention includes determining expression of at least three genes selected from the group consisting of GBX2, MKI67, CCNB1, BUB1, KNTC2, USP22, HCFC1, RNF2, ANK3, FGFR2, and CES1, and mouse homologs thereof.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: January 8, 2013
    Inventor: Gennadi V. Glinskii
  • Patent number: 8352015
    Abstract: A method and apparatus are provided for determining and tracking location of a metallic object in a living body, and then directing a second modality such as ultrasound waves to the determined location. The metal detector may be a radar detector adapted to operate on a living body. The adaption may include disposing a transfer material having electromagnetic properties similar to the body between the radar detector and the living body, ECG gating the radar detector, and/or employing an optimal estimator with a model of expected stent movement in a living body. Applications include determination of extent of in-stent restenosis, performing therapeutic thrombolysis, or determining operational features of a metallic implant.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: January 8, 2013
    Assignee: Kyma Medical Technologies, Ltd.
    Inventors: Assaf Bernstein, Uriel Weinstein, Vered Cohen Sharvit, Dov Oppenheim
  • Patent number: 8350020
    Abstract: Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs:1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified herein or their variants, homologs or functional derivatives. Further provided are expression vectors comprising such TEEs or translational enhancer polynucleotides, as well as host cells and expression systems that harbor such vectors.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: January 8, 2013
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Wei Zhou
  • Patent number: 8351366
    Abstract: Techniques and systems for mediating traffic between a network transceiver and a user transceiver in a wireless communication system are disclosed. A network link with the network transceiver is maintained using a network unit, and a user link with the user transceiver is maintained using a user unit. One or more replicas of a signal received from the network transceiver on a downlink path or from the user transceiver on an uplink path, respectively, are generated. The one or more replicas of the signal wirelessly are then transmitted on a hop between the network unit and the user unit along with a bi-directional control channel.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: January 8, 2013
    Assignee: Nextivity, Inc.
    Inventors: Behzad B. Mohebbi, Louis Botha
  • Patent number: 8349337
    Abstract: The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a cholesterol-reducing agent for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: January 8, 2013
    Assignee: Ganeden Biotech, Inc.
    Inventors: Sean Farmer, Andrew R. Lefkowitz
  • Patent number: 8343996
    Abstract: The present invention provides compounds and methods for treating or preventing the development of a disease, disorder, or condition in a subject or patient.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: January 1, 2013
    Assignee: AstraZeneca AB
    Inventor: Mark E. Duggan
  • Patent number: 8343484
    Abstract: The invention relates generally to digestive disorders, and in particular to methods for treating irritable bowel syndrome by increasing carbohydrate absorption by administering a composition containing a Bacillus coagulans bacterium.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: January 1, 2013
    Assignee: Ganeden Biotech, Inc.
    Inventors: Sean Farmer, Andrew Lefkowitz
  • Patent number: 8344123
    Abstract: An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species, wherein each first amplicon comprises a plurality of amplified copies and is amplified with a pair of nucleic acid primers that define a locus of the first amplicon; clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons wherein a plurality of the second amplicons comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition of the substantially identical copies from at least 100 of the immobilized populations in parallel on a single substrate; and detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic ac
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: January 1, 2013
    Assignee: 454 Life Sciences Corporation
    Inventors: Birgitte Binderup Simen, Elizabeth Patricia St. John
  • Patent number: 8342091
    Abstract: A portable cable marking mechanism includes a gun-like housing with a pivotally mounted trigger assembly for moving a stamping unit along a predetermined inking path to engage in sequence an inking pad of a replaceable ink cartridge for inking the stamping unit and then a cable sleeve for providing the cable sleeve with customized indicia markings.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: January 1, 2013
    Inventor: William Bourgeois
  • Patent number: 8343977
    Abstract: The present invention relates to substituted triazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted triazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: January 1, 2013
    Assignee: ArQule, Inc.
    Inventor: Syed M. Ali
  • Patent number: 8343961
    Abstract: The present invention relates to substituted heterocyclic compounds and substituted tetrahydroisoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzodiazepine compounds and substituted tetrahydroisoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: January 1, 2013
    Assignee: ArQule, Inc.
    Inventors: Robert Nicewonger, Audra Dalton, Chris Brassard, Mark A. Ashwell, Rocio Palma
  • Patent number: 8343983
    Abstract: The present invention relates to substituted pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: January 1, 2013
    Assignee: ArQule, Inc.
    Inventors: Manish Tandon, Jianqiang Wang, Nivedita Namdev
  • Patent number: 8346613
    Abstract: Solutions for e-commerce merchants that allow such merchants to interact with buyers in foreign jurisdictions are disclosed. More specifically, solutions are presented that provide an intermediation service that operates to provide variants of e-commerce (or other) Web sites in a local language of a visitor to such site, such variants including facilities to accept payments for goods or services in the currencies and/or payment forms of the foreign jurisdiction and to provide the e-commerce merchant with required shipment documents to assist in order fulfillment.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: January 1, 2013
    Inventor: Marc Raygoza
  • Patent number: 8343089
    Abstract: One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: January 1, 2013
    Assignee: Silk Road Medical, Inc.
    Inventor: David W. Chang
  • Patent number: 8347090
    Abstract: A method and apparatus including units configured to send a request from a first network entity to a user equipment for an identifier and receive a message indicating that a public key is required from the user equipment by the first network entity. The method and apparatus also includes units configured to send, by the first network entity, the public key to the user equipment and receive an encrypted identifier by the first network entity, wherein upon authenticating the public key, the user equipment encrypts at least part of the identifier using the public key, thereby enabling further processing between the network entity and the user equipment.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 1, 2013
    Assignee: Nokia Corporation
    Inventors: Silke Holtmanns, Dan Forsberg
  • Patent number: 8341700
    Abstract: The invention proposes a system for authenticating and authorizing network services comprising: a mobile device being adapted to, upon receipt of an information message indicating at least one network access type, determine the network access type, to create a start message containing at least a user identity, and to encapsulate the start message in an authentication message compatible with the access network identified in the information message, and an access controller for reading the encapsulated message from the mobile and forwarding the encapsulated message to an authentication server identified in the encapsulated message. The invention also proposes a corresponding method for authenticating and authorizing network services, and an access control device, a subscriber device and a router device.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: December 25, 2012
    Assignee: Nokia Corporation
    Inventors: Jari T. Malinen, Timothy J. Kniveton, Meghana Sahasrabudhe
  • Patent number: 8337879
    Abstract: The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency. The compositions preferably comprise a finely powdered, carboxylic acid salt and a liquid block copolymer of ethylene oxide and propylene oxide.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: December 25, 2012
    Assignee: ORTHOCON, Inc.
    Inventor: Richard L. Kronenthal
  • Patent number: D673820
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: January 8, 2013
    Assignee: Hockey Stick Putters, Inc.
    Inventor: Angela Batchelder