Patents Represented by Attorney Morton S. Simon
  • Patent number: 6478790
    Abstract: An implant device comprises a tubular member having a bore, a charging end and a pointed elongated annular concavely beveled implanting end. A rod is removably insertable within the bore for delivery of an implant dosage form charged within the bore. A stop member for hindering movement of the rod sufficiently to prevent unintentional delivery of the implant dosage form but not sufficient to prevent same when delivery is intended is mounted on the tubular member. A truncated cylindrical solid shaped implant dosage form having an ellipsoidal face is positioned in the bore at the implanting end in alignment with same so that a substantially continuous elipsoidal surface is presented.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: November 12, 2002
    Inventor: Frank M. Bardani
  • Patent number: 6348439
    Abstract: The invention provides compositions for providing body, fullness and texture to otherwise fine or very fine keratinous fibers, particularly human hair. The compositions of the present invention have a high pH, e.g., about 8 to about 10 when the compositions contain cationic polymer, and a pH of about 8 to about 14, preferably about 8.5 to about 13, and more preferably, about 8.5 to about 10 when the compositions contain no cationic polymer. The compositions include one or more nonionic and/or cationic polymers, which, in combination with the high pH of the composition, lift the hair cuticle and allow the deposition of polymer, thus resulting in increased fullness and texture to the hair. The compositions of the present invention may be in the form of known hair care products such as, for example, shampoos, rinses and conditioners. In addition, the compositions can be formulated, for example, as lotions or creams, and the like, for consumer use.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: February 19, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter J. Rousso, Paul S. Wallace
  • Patent number: 6256809
    Abstract: There is disclosed a waste prevention system which avoids the discharge, inadvertent or otherwise, of laboratory waste, into a public sewage system and subsequently into the natural environment. The system employs, in combination, a laboratory sink having cooperatively connect thereto a carboy for collecting pollutants. The carboy is provided with elements to permit removal of samples of materials delivered thereto from the sink for testing of the same to determine the presence of pollutants. In the event no pollutants are present, the carboy may simply be opened and any wash or rinse water from the sink can be delivered into a public sewage system and then to the environment.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: July 10, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Norman Goldschmidt, Andrew Hahn
  • Patent number: 6160127
    Abstract: A process for the preparation of 5,6-disubstituted indoles in which a 4-5-disubstituted-2,.beta.-nitrostyrene is subjected to a reductive cyclization in the presence of a water soluble dithionite salt.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: December 12, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Giuseppe Prota, Gottfried Wenke
  • Patent number: 6106917
    Abstract: A hair dye product is packaged in a container having a web-printed label. The label is printed on high quality paper or plastic film and has a picture of a human model whose hair is the color sought to be obtained by the hair dye. The printing process provides an accurate reproduction of the tone and hue of each hair color over the entire production run of the labels. The container may be a relatively low cost generic container of web-printed paperboard or plastic produced in a high volume production run.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: August 22, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph J. Pereira, Kimberly A. Slavin, Nicola Delli Venneri
  • Patent number: 6074438
    Abstract: The invention provides compositions and methods for the oxidative coloring of human hair. The compositions of the invention contain as a primary intermediate at least one aminophenol of the formulas: ##STR1## or a cosmetically acceptable salt thereof, and at least one pyrazolone coupler of the formulas: ##STR2## or a cosmetically acceptable salt thereof. The compositions may also contain one or more other primary intermediates and conventional coupling compounds, in addition to an oxidizing agent and other components typically used in oxidative hair dye preparations.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: June 13, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Mu-Ill Lim, Yuh-Guo Pan, Linas R. Stasaitis
  • Patent number: 6071188
    Abstract: An exhaust system has an air exhaust duct having a charge opening and a discharge opening and defining an air flow path. A damper is mounted in the duct for maintaining a constant air velocity for air exiting the discharge opening. The damper has opposing damper blades pivotally mounted within the duct. Each damper blade has an end that is pivotally mounted in cantilevered fashion within the duct so that an opposing end is free to move within the duct. Each damper blade is parabolic in shape and minimizes the air turbulence over the damper blade and reduces vibration. Each damper blade can be pivoted in response to a change in air volume discharged through the discharge opening to maintain a desired velocity of air through the discharge opening.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: June 6, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Charles H. O'Neill, Norman A. Goldschmidt, Ronald L. Benjamin
  • Patent number: 6045590
    Abstract: Compounds of Formula II ##STR1## wherein R.sub.3 is --COOCH.sub.3, --COCH.sub.3 or --COCH.sub.2 CH.sub.3 and R.sub.4 is hydrogen or R.sub.3 is hydrogen and R.sub.4 is --OCH.sub.3, --OC.sub.2 CH.sub.3, --OCH.sub.2 CH.sub.2 OH or --OCH.sub.2 CH.sub.2 OCH.sub.3 are storage stable and can be used in oxidative hairdye systems in place of the storage unstable 2-methyl-1-naphthol. Advantageously, it has been found to produce the same colors as 2-methyl-1-naphthol.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: April 4, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Mu-Ill Lim, Yuh-Guo Pan, Linas R. Stasaitis, John D. O'Donoghue
  • Patent number: 6023661
    Abstract: A fully automated computer controlled system and method to simultaneously measure in a dynamic mode the streaming potential, impedance and permeability resulting from a flow of various liquids through a sample, particularly a compressed mass of human hair. The system includes four air-pressurized reservoirs and three test cells, each test cell containing a sample to be tested. An impedance measurement is made by impressing a signal wave train across each sample over a selected range of frequencies, preferably in the 10-10,000 Hz range, rather than at a single frequency. The air pressure is controlled within 2% of a selected pressure and the outlet flow of liquid from the test cells is continually measured to provide an accurate and reproducible set of measurements.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: February 8, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventor: John P. Sottery
  • Patent number: 6019988
    Abstract: The invention provides methods and means for enhancing the epidermal, transdermal and dermal permeation of a topically applied pharmacologically active agent (e.g., a drug or medicament) which has a low rate of skin penetration in the absence of a permeation enhancer and which is unstable and degrades during long-term storage with particular permeation enhancers. Also provided by the invention are methods and means to increase the skin penetration of a pharmacologically active agent which has a normally low rate of skin permeation and causes the instability and degradation of a permeation enhancer with which it is combined over a long period of time. Provided by the invention are at least one first composition containing a drug, a pharmaceutically acceptable salt, chemical derivative or formulation thereof, in a dermatologically acceptable vehicle, and at least one second composition containing a permeation enhancer in an acceptable vehicle.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: February 1, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Prakash Parab, Cheng Der Tony Yu, Bhiku Patel
  • Patent number: 6010690
    Abstract: The invention provides compositions for relaxing and conditioning keratinous fibers, particularly human hair. The compositions of the present invention have a high pH, i.e., a pH greater than 10, preferably, in the range of about 11 to about 14, more preferably about 12 to about 13.5, and include as a conditioning additive a cationic guar. Surprisingly, the cationic guar maintains stability, viscosity and activity over time in the highly alkaline pH of the inventive hair relaxer and conditioning compositions of the present invention. The relaxer compositions of the present invention afford beneficial effects to the user, such as softness and ease of wet combing, and cause less damage to hair following application and use. In addition, the conditioning relaxer compositions of the present invention remain on the hair and provide lasting conditioning and relaxing effects after one or more shampoos.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: January 4, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventor: Joseph J. Varco
  • Patent number: 5989532
    Abstract: A hair treatment composition comprising a mixture of polyvinylpyrrolidone and a member selected from the group consisting of an ethoxylated triglyceride, a quaternary ammonium chloride, phenyl trimethicone, an acrylate containing polymer and dimethicone copolyol ester and mixtures thereof, provided that the weight ratio of the polyvinylpyrrolidone to the ethoxylated triglyceride is greater than about 7:1 and the weight ratio of the polyvinylpyrrolidone to the acrylate containing polymer is greater than about 7:1 is described herein.
    Type: Grant
    Filed: November 27, 1997
    Date of Patent: November 23, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Linda J. Haning, Coreen Ann Johnson
  • Patent number: 5980584
    Abstract: The novel primary intermediate, 1-(5-amino-2-hydroxyphenyl)ethane-1,2-diol and a method for producing same, are disclosed. The novel intermediate can be employed as a replacement for p-aminophenol in oxidation dye formulations.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: November 9, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mu-III Lim, Linas R. Stasaitis, Yuh-Guo Pan, Michael Y. M. Wong
  • Patent number: 5964149
    Abstract: A method of printing multi-color images on pressure sensitive labels carried on a web uses a disk shaped mark for each color which is printed to form the image. The disks (spots) are printed on the image, or elsewhere on the top layer of the web, with one disk being printed on top of the other, so that the marks coincide in size, shape and position. If a color is misregistered, it appears as a crescent which extends beyond the multi-colored disk. Such misregistration may be immediately viewed on a video magnifier, using at least 400.times. magnification, and the misregistration corrected.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: October 12, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Nicola Delli Venneri, Joseph J. Pereira, Kimberly A. Slavin
  • Patent number: 5961666
    Abstract: A 2-Substituted-1-naphthol of the formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl or monohydroxy C.sub.1 -C.sub.6 alkyl couples with a primary intermediate of the formula: ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl or monohydroxy C.sub.1 -C.sub.6 alkyl to produce an oxidative dye.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: October 5, 1999
    Inventors: Mu-Ill Lim, Yuh-Guo Pan, James S. Anderson
  • Patent number: 5961664
    Abstract: An anthraquinone mixture comprising three 1,4-hydroxyalkylamino-anthraquinone derivatives, wherein two of the anthraquinone compounds in the mixture are symmetric and the other anthraquinone compound is asymmetric, and wherein each of the anthraquinone compounds has similar polarities. The anthraquinone mixtures are used in compositions and methods for the direct dyeing of keratinous fibers, particularly human hair on the head.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: October 5, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventor: James S. Anderson
  • Patent number: 5885596
    Abstract: The invention provides methods and compositions for improving and reducing age-related skin disorders, particularly fine lines and/or wrinkles, including fine wrinkles, on human skin. The cosmetic compositions of the invention are formulated with less than effective amounts of anti-wrinkle active agents (e.g., drugs) or are devoid of such active agents, which include .alpha.-hydroxy acid and derivatives and salts thereof, tretinoin and derivatives and salts thereof, or vitamin C, and which are typically used for treating and reducing skin lines and/or wrinkles. As tested in clinical trials, the compositions of the invention reduced and improved fine lines and/or wrinkles as well as, or better than, preparations containing .alpha.-hydroxy acids, .alpha.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: March 23, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventor: Prakash Parab
  • Patent number: 5880380
    Abstract: There is disclosed a high containment device, apparatus or system for withdrawing sample material from process or manufacturing equipment with substantially no leakage of the sample material to the external environment and which is of syringe-type construction, thus preventing possible contamination of such environment or workers operating processing and/or production equipment in such a situation, especially where hazardous materials are involved. The high containment device, apparatus or system disclosed is used in combination with process or manufacturing equipment thus providing a system which results in the prevention of leakage of possible hazardous material to the environment and possible contamination of equipment operators thereby.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: March 9, 1999
    Inventors: Norman Goldschmidt, Kenton Shultis
  • Patent number: 5876464
    Abstract: N-(4-Aminophenol) prolineamide and cosmetically acceptable salts thereof are useful as primary intermediates in oxidative hair dyeing. Compositions which contain a hair dye produced by oxidatively coupling N-(4-aminophenol) prolineamide with a coupler in the presence of an oxidizing agent are applied to the hair in oxidative hair dyeing processes.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: March 2, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mu-Ill Lim, Margaret A. Popp, Yuh-Guo Pan
  • Patent number: 5868288
    Abstract: A dispensing container comprising a molded plastic bottle and a cap. The molded plastic bottle has a top closed end, a cylindrical side wall, and a shoulder section at a dispensing end of the side wall. The shoulder has one or more indented portions which form the positioning lugs in the shoulder section. The plastic bottle also has a neck with external threads defining a mouth. The cap is selectively connected to the neck. The cap has an internally threaded cuff for interconnection with the external threads of the neck. The cap also has structure for dispensing of an enclosed material which is near the mouth. The cap is cup-shaped with a face and a cylindrical wall extending from the face to define an interior of the cap. When the cap is connected to the neck, the indented portions which form the positioning lugs in the shoulder are hidden from view within the interior of the cap.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 9, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas M. Redmond, Sr., Timothy E. Fitten, Linda C. Nash, Robin Laraine Doyle