Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.

Abstract: A (+)or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.

Abstract: Compounds of formula (I), wherein R.sup.1 represents halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, NO.sub.2, --NR.sup.4 R.sup.5, R.sup.4 R.sup.5 NCO(CH.sub.2).sub.m --, R.sup.4 R.sup.5 NSO.sub.2 (CH.sub.2).sub.m --, R.sup.6 CONH(CH.sub.2)-.sub.m or R.sup.7 SO.sub.2 NH(CH.sub.2).sub.m --; R.sup.4 and R.sup.5 each independently hydrogen or C.sub.1-4 alkyl or NR?.sub.4 R.sup.5 represents a 5- to 7-membered heterocyclic ring, R.sup.6 represents hydrogen or C.sub.1-4 alkyl; R.sup.7 represents C.sub.1-4 alkyl; m is zero, 1 or 2; n is zero or 1 to 5; R.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl or benzyl or --NR.sup.2 R.sup.3 represents a pyrrolidino, piperidino or hexahydroazepino ring, and A represents a bond, a C.sub.1-5 alkylene chain or a C.sub.3-5 alkenyle chain wherein the double bond is not adjacent the nitrogen atom; and salts thereof have affinity for the 5-HT.sub.1 -like receptor and are useful e.g. in the treatment of migraine.

Abstract: This invention relates to a novel, multisegmented nozzle for dispensing viscous materials, particularly for dispensing differently colored toothpaste into toothpaste tubes so as to produce toothpaste of striped appearance when dispensed from the tube. The nozzle has a tubular body defined by an outer body wall, and has within the tubular body a central channel and a plurality of longitudinal first and second side channels situated around the central channel. The first side channels have a cross section which narrows towards the central channel; the second side channels have a rectangular cross section. Because of this configuration the nozzle is able to load multicolored toothpaste tubes which dispense toothpaste in a substantially more uniform striped pattern than conventionally loaded multicolored toothpaste tubes.

Abstract: A compound of the formula A.sup.1 --X--(CH.sub.2).sub.n --O--A.sup.2 --A.sup.3 --CO.R.sup.2 (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group; A.sup.2 represents a benzene ring having three optional substituents; A.sup.3 represents a moiety of formula --(CH.sub.2).sub.m --CHR.sup.1 -- wherein R.sup.1 represents a halogen atom or a moiety of formula S(O).sub.p A.sup.4 wherein A.sup.4 represents hydrogen, substituted or unsubstituted alkyl, aryl, aralkyl, alkylcarbonyl or an aromatic heterocyclyl group and p represents zero or an integer 1 or 2 and m represents zero or an integer in the range of from 1 to 5, or A.sup.3 represents a moiety of formula --CH.dbd.CR.sup.1 -- wherein R.sup.1 is as defined above; R.sup.2 represents OR.sup.3 wherein R.sup.3 represents hydrogen, alkyl, aryl or aralkyl, or R.sup.2 represents --NR.sup.4 R.sup.

Abstract: The present invention relates to known and novel tryptamine analogues, processes and intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy, in particular for the treatment and/or prophylaxis of disorders characterized by excessive vasodilatation, such as migraine and portal hypertension.

Abstract: Compounds of formula (I), ##STR1## wherein R.sup.1 represents C.sub.1-4 alkyl; and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently represent hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxyC.sub.1-4 alkyl, C.sub.1-4 alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkanoyl, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R.sup.1 and R.sup.2 together form a linking chain-(CH.sub.2).sub.m Op (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C.sub.1-4 alkyl groups; and Y represents a group selected from (a) or (b) wherein R.sup.6 and R.sup.7 independently represent hydrogen, C.sub.

Abstract: A douche nozzle has an internal baffle member for regulating the flow of liquid exiting the nozzle. The nozzle may be provided with spaced apart grooves on its exterior surface extending from the distal end of the nozzle to and across an internally threaded open base.