Abstract: This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.
Abstract: Mouthwash compositions are described comprising cetylpyridinium chloride and amidobetaine amphoteric surfactants of formula (I): RC(O)NH(CH.sub.2).sub.a N.sup.+ (R.sup.1)(R.sup.2)(CH.sub.2).sub.b CO.sub.2.sup.-, wherein R is C.sub.10-20 alkyl; R.sup.1 and R.sup.2 are independently C.sub.1-4 alkyl; a is an integer from 1 to 4; and b is an integer from 1 to 4.
Type:
Grant
Filed:
November 25, 1998
Date of Patent:
September 12, 2000
Assignee:
SmithKline Beecham p.l.c.
Inventors:
Mark Andrew Wicks, Peter Scott McConville, Paula Walsh
Abstract: A toothbrush, in the neck region of which there is an integral thinned part laterally surrounded by a mass of elastomeric material bonded to the plastics material, the mass being of a shape which bulges laterally beyond the line of the surface of the longitudinally adjacent parts of the neck or the head to which it is connected. The thinned part and the bulging mass provide a toothbrush of improved flexibility.
Abstract: This invention relates to a pharmaceutical composition for use as a direct compression tableting agent containing carbonyl iron and a process for making the same.
Abstract: This invention relates to a process for making a toothbrush comprising making a toothbrush head having at its basal end a first engagement part, then making a toothbrush grip handle from a plastics material by a handle molding process, during the handle molding process forming a second engagement part at the head end of the handle in engagement with the first engagement part, such that the engagement between the first and second engagement parts retains the head and grip handle together, and toothbrushes made by this process.
Abstract: A pump dispenser suitable for striped toothpaste, comprising a pump head [1] and a replaceable reservoir [2] for the toothpaste, in which the toothpaste is packed in radially disposed segments, and the reservoir is locked against rotation relative to the pump head.
Abstract: This invention relates to compounds of formula (I): ##STR1## which are useful as modulators of D.sub.3 receptors, in particular in the treatment of psychoses.
Abstract: The present invention is to a process for producing a matrix particle of a colored lake or dye which matrix reduces the leeching or bleeding of the colored lake or dye into the surrounding medium. The present inventive process is particularly useful in toothpaste formulations.
Type:
Grant
Filed:
May 14, 1998
Date of Patent:
March 14, 2000
Assignee:
SmithKline Beecham Corporation
Inventors:
Howard Chang, Indrajit N. Desai, Arthur Vinen
Abstract: Two phase remineralizing compositions are described comprising a source of calcium ions and a source of phosphate ions together with a water soluble polyphosphate salt.
Abstract: This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D.sub.3 receptors, in particular as antipsychotic agents.
Type:
Grant
Filed:
October 29, 1997
Date of Patent:
December 28, 1999
Assignee:
SmithKline Beech p.l.c.
Inventors:
Geoffrey Stemp, Christopher Norbert Johnson
Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
Type:
Grant
Filed:
December 23, 1996
Date of Patent:
October 5, 1999
Assignee:
SmithKline Beecham, p.l.c.
Inventors:
Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young