Abstract: A toothbrush in which the head comprises a substantially rigid base region adjoining the toothbrush neck and extending from the base end of the head to a resilient flexible link situated between the base end and the tip end, and a tip region extending from the tip end of the head to the link region, both the base region and tip region being bristle bearing, the tip region being flexibly and resiliently linked at the link region to the base region, and between the base end of the head and the neck there is a resilient flexible link.

Abstract: A display for a flexible head toothbrush includes a first representation of a first bristled portion of a toothbrush head and a second representation of a second bristled portion of a toothbrush head. The first representation is interconnected with the second representation by a mechanical linkage. The mechanical linkage provides oscillatory pivotal movement of the second representation with respect to the first representation. The mechanical linkage is preferably an electromagnet motor, such as a self-starting swinging apparatus, powered by a solar cell. The second representation preferably depicts a tip end of the toothbrush head, while the first representation depicts a remaining portion of the toothbrush head. The display may also include a third representation of at least a portion of a toothbrush handle extending from the first representation. Further, the display may include a support having shelves that hold actual toothbrushes.

Abstract: A denture adhesive base composition consisting essentially of polyvinyl pyrrolidone and ethylene oxide polymer. A denture adhesive composition including this base composition is also provided with other optional adhesive components. Also is provided a method for formulating a novel denture adhesive base composition consisting essentially of polyvinyl pyrrolidone and ethylene oxide polymer.

Abstract: A compound, or a solvate or a salt thereof, of formula (I), wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R, R1, R2 and R3 are as defined in the description; a process for the preparation of such a compound, a pharmaceutical composition containing such a compound or composition in medicine.

Abstract: In making a toothbrush of the type having a shaft-like handle (3), a neck section (4) joining the handle and a head (5) for holding a plurality of toothbrush bristles (6), the body is made of a first plastic material through an injection molding step. In order to provide the body with two or more portions (20, 21, 22) made of a second material, e.g., elastic and/or non-slip material such as rubber-like material, or a material having a color different from that of the first material, the toothbrush body is provided with recess sections (17, 18, 19). The second material is supplied through a plurality of channels (29, 30, 31, 32) into injection nozzle means (33, 34, 35) to provide injection of the second material in a single step, multi-point injection process into the recesses on the body to form the portions (20, 21, 22), the recesses (17, 18, 19) and the portions (20, 21, 22) thus being physically isolated from each other by the first material.

Abstract: The present invention provides compounds of formula (I): which are useful as antipsychotic agents.

Abstract: This invention relates to substituted bis-acridines and related compounds which are ligands, in particular, antagonists of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders, rheumatoid arthritis, atherosclerosis, psoriasis, auto immune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted bis-acridines and related compounds which are CCR5 receptor antagonists. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor ligands may be useful in the treatment of HIV infection.

Abstract: The compositions of the present invention are useful for the topical delivery of a wide variety of active ingredients. These compositions are particularly useful for treating conditions such as acne and its attendant skin lesions, blemishes, and other imperfections. These compositions are nonirritating to the skin and also provide skin feel benefits. These compositions can be in the form of leave-on products and products that are rinsed or wiped from the skin after use.

Abstract: A mixing device for fluids, comprising a column within which there is an internal core, a space between the column and core defining a channel for the flow of the fluids, the surface of the column facing the core having fluid guide elements which impart helical flow in a first twist direction upon a fluid flowing along the channel, the surface of the core having fluid guide elements thereon which impart helical flow in an opposite twist direction upon the fluid. On part of the channel, the helical flow imparted to the fluid is predominantly in the twist direction of the elements on the core and on a part of the channel upstream or downstream of this part the helical flow imparted to the fluid is predominantly in the twist direction of the elements on the column.

Abstract: A skin wash composition intended for topical application to water-wetted skin comprising an .alpha.-hydroxy acid active ingredient formulated in a mild and non-irritant detergent base consisting of a mixture of a non-ionic alkylpolyglucoside surfactant and an amphoteric surfactant.

Abstract: A pharmaceutical tablet, with a break line aligned along a long dimension of the tablet, such that a twisting action, in which parts of the tablets on opposite sides if the break line are subjected to a rotational twisting force in respectively opposite senses, causes the tablet to break into two or more parts. The tablet is of the type which may be broken into two or more parts in order to ease swallowing or to allow administration of a partial dose.

Abstract: Compounds of formula (I), wherein R.sup.1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, arylC.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkoxyC.sub.1-4 alkyl, C.sub.3-6 cycloalkylC.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkylsulphonyl, C.sub.1-4 alkylsulphonyloxy, C.sub.1-4 alkylsulphonylC.sub.1-4 alkyl, arylsulphonyl, arylsulphonyloxy, arylsulphonylC.sub.1-4 alkyl, C.sub.1-4 alkylsulphonamido, C.sub.1-4 alkylamido, C.sub.1-4 alkylsulphonamidoC.sub.1-4 alkyl, C.sub.1-4 alkylamidoC.sub.1-4 alkyl, arylsulphonamido, arylcarboxamido, arylsulphonamidoC.sub.1-4 alkyl, arylcarboxamidoC.sub.1-4 alkyl, aroyl, aroylC.sub.1-4 alkyl, or arylC.sub.1-4 alkanoyl group; a group R.sup.3 OCO(CH.sub.2).sub.p, R.sup.3 CON(R.sup.4)(CH2)p, R.sup.3 R.sup.4 NCO(CH.sub.2).sub.p or R.sup.3 R.sup.4 NSO.sub.2 (CH.sub.2).sub.p where each of R.sup.3 and R.

Abstract: The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavor which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.