Abstract: An impurity scavenger pillow or capsule and method for removing water or keeping water levels low in a solvent container with minimal particulate or chemical contamination, comprising a pillow consisting essentially of a porous bag containing a desiccant material, said pillow being formed through folding and sealing adjacent layers of the bag or comprising a capsule consisting essentially of a solid cylinder with the end or ends being a porous material.

Abstract: The device of the present invention includes a flexible container having an administration port and a flexible tube extending therefrom. The administration port includes an access membrane through which a spiked cannula can be inserted to gain access to the interior of the flexible container. The flexible tube contains a frangible or breakaway valve therein. Permanently secured to the end of the flexible tube is a sheath having a substantially circular base and an open-ended skirt including an inner surface depending from the base. The skirt includes a plurality of inwardly projecting bumps intermittently spaced around the inner surface to sealingly engage a standard drug vial. A sharp cannula is mounted within the skirt to pierce the stopper of the standard drug vial to establish fluid communication between the cannula and the interior of the drug vial. A peelable closure is provided covering the skirt opening prior to use to maintain a sterile condition of the device.

Abstract: A pharmaceutical composition is provided comprising an unbuffered iso-osmotic aqueous formulation containing an effective amount of ranitidine for the treatment of conditions mediated through histamine H.sub.2 receptors. The formulation has a pH of greater than or equal to 5.0 and less than 6.5 and preferably includes an osmotic adjusting agent chosen from the group consisting of dextrose and sodium chloride.

Abstract: A method is provided for cleaning an article with a solvent having a boiling point such that the solvent is a gas at room temperature and one atmosphere pressure. Such a method includes the steps of disposing the article in a chamber, introducing the solvent into the chamber so that the solvent contacts the article, pressurizing the chamber so that the solvent is in a liquid state and removes contaminants from the article, purging the chamber to remove the solvent, and removing the treated article from the chamber. Such a system permits the use of liquids having boiling points lower than room temperature, such as certain C.sub.1 -C.sub.4 halocarbons, which liquids have not previously been used as cleaning solvents.

Abstract: A container for housing a beneficial agent that can be removably coupled to a structure defining a fluid flow path. The container comprises a body defining a first and second interior area separated by a wall that terminates at an opening providing fluid communication between the first and second interior area. A cannula is provided that extends from the body for being removably received by the structure defining the fluid path. The cannula includes an inlet opening and inlet fluid flow path and an outlet opening and outlet fluid flow path. The inlet fluid flow path being in fluid communication with the first interior area, and the outlet fluid flow path being in fluid communication with the second interior area. The second interior area houses the solid beneficial agent and allows fluid that flows through the inlet fluid flow path to pass by at least a portion of the beneficial agent.

Abstract: A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method expose the fluid, as it transits the gap, to a source of radiation that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap.

Abstract: The present invention provides a casing having a plurality of sources of pressurized liquid. The sources of pressurized liquid are preferably contained in at least one elastomeric bladder. Housing is provided to establish fluid communication between the sources of pressurized liquid. Additionally, at least one flow restrictor is provided to regulate the flow of pressurized liquid. A single or a plurality of flow restrictors can be used to regulate the flow of liquid between the sources of pressurized liquid. The plurality of sources of pressurized liquid can be contained under different pressures which can be provided by varying the size of the elastomeric storage area. The casing further contains an inlet port and an exit port in fluid communication with the sources of pressurized liquid to provide for filling and dispensing of the fluid.

Abstract: A device for holding a tendon graft in position as the tendon is scraped and sutured is described. The device includes a pair of tension arms that can be moved in both a horizontal and vertical plane. Horizontal movement of the tension arms can be used to adjust the amount of tension that is applied to a tendon graft. Vertical movement of the tension arms can be used to position the tendon graft in a location which enables medical personnel to more easily suture parallel lengths of a graft together.

Abstract: Systems for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a relatively narrow, arcuately shaped flow path. These systems envelop the path with a radiation chamber that directs radiation from one or more sources into the fluid.

Abstract: A system for evaluating the physical compatibility of two or more pharmaceutical chemicals in solution mixes chemical solutions in predetermined relative quantities in a test well and, under the direction of a control mechanism, measures the absorption of the mixture at two different wavelengths. The first wavelength is within the visual spectrum in the range of 400 to 500 nm and detects both changes in color and changes in physical properties caused by mixing the chemical solutions. The second wavelength is above the visual spectrum in the range of 610 to 650 nm to detect only changes in physical properties caused by mixing the chemical solutions. The control mechanism further compares the absorption measured at the two different wavelengths to differentiate between solely color changes and physical property changes (with or without color changes) caused by the mixing. The control mechanism also provides an output of the differentiated results.

Abstract: A one-piece unitary frangible spike connector for insertion into solution containers includes a spike body formed with a closure on one end thereof and a tubing receptacle on the other end thereof. An internal conduit extends from the tubing receptacle through the spike body partially into the closure. The frangible spike connector is broken apart along a reduced diameter portion tapered or formed at an angle to form a spike connected to the conduit on the spike body when the closure is broken off the spike body.

Abstract: Systems and methods of collecting blood cells use a first container connected to at least three transfer containers. A filtration system is provided with one transfer container, which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers are connected to each other, one of which is empty and one of which contains and additive solution for storage of red blood cells. The empty transfer container is used for storage of platelet concentrate, while the container that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution may be separately passed through the filtration system after filtration of the red cells to flush additional red blood cells from the filtration device.

Abstract: A method of determining the critical vapor pressure of a hygroscopic material, such as a drug. A drug sample is placed in a substantially isothermal environment. A vapor, such as water vapor, at a given pressure is then placed in the ambient air over the drug. The rate of heat production from this sample at the given water vapor pressure, or the humidity of the air above the sample, is then measured. The water vapor pressure over the drug is gradually increased. Simultaneously, the rate of increase in heat production from the drug sample, or the rate of change of the relative humidity of the air above the drug sample, is measured. A marked increase in the rate of heat production generated by the drug, or a marked change in the relative humidity of the air over the sample, signals the attainment of the critical water vapor pressure.

Abstract: A holder for storing a specimen tray with a removable cover member includes a frame with oppositely facing first and second access openings The first access opening receives the specimen tray and cover member. The holder supports the specimen tray and cover member within the storage area between a pair of oppositely spaced tray support ledges. The second access opening receives an external member that moves vertically in the storage area to lift the specimen tray from the tray support ledges and that moves horizontally out of the storage area to move the lifted specimen tray from the storage area through the second access opening. The holder pivots the cover member away from the specimen tray to retain the cover member in a tilted orientation within the storage area free of the removed specimen tray until its return.

Abstract: Disclosed is an elastomeric bladder infusion pump which may be used for delivering a pharmaceutically active material to a patient at a substantially constant flow rate. A unitary internal stress member or mandrel is disposed within the bladder, prestressing the bladder in both the axial and radial dimensions.

Abstract: A scissor-like device is described which can be used to measure the diameter of a tendon graft or bone plug. The device can also be used to hold a tendon graft or bone plug in a fixed position while multiple sutures are inserted in the end thereof. The device includes a pair of arms which are hinged at the proximal end. The inner surface of each arm includes a series of semicircular sizing sleeves which mate with one another to form a series of cylindrical sleeves of increasing diameter. A tendon graft or bone plug can be placed in the series of sleeves to determine the proper diameter of the graft or plug. Various measuring indicia are provided along the arms of the device to provide an indication of both the diameter and length of tendon tissue to be measured.

Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.

Abstract: A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is disclosed and claimed.

Abstract: A processing system separates a cellular rich suspension into a cellular first constituent and cellular-free second constituent. The system includes a separation zone that receives the cellular rich suspension and discharges the first and second constituents. The system coordinates the flow of cellular rich suspension into the separation zone with the flow of the cellular-free second constituent from the separation zone to get a desired nominal separation efficiency. The system also recirculates the cellular first constituent back into the zone. By continuously recirculating the cellular first constituent back into the separation zone, the system is can get and maintain a desired volume of the first constituent, despite the volume of cellular rich suspension that is processed.

Abstract: A surgical ophthalmic drape which is a complete draping system and provides a sterile field and fluid control. The ophthalmic drape includes a main sheet and a fluid pouch. The fluid pouch has a fenestration which is smaller than the main sheet fenestration. The adhesive layer on the bottom of the fluid pouch both secures the pouch to the main sheet and also secures the drape assembly to the patient. The pouch is a folded piece of fluid impervious material with a sealed edge on three sides.