Abstract: By the addition of a relatively small amount of N-(acenaphthenyl)maleimides carrying optional substituents, synthetic films, plastics, woven or knitted synthetic or cellulosic fabrics, or paint can be protected against fungal and bacterial deterioration.
Abstract: Gibberellin A.sub.4 can be separated from the mixture of gibberellin A.sub.4 /A.sub.7 by placing a dilute aqueous mixture thereof at the pH of at least 9 for one day or more and subsequent adjustment of the pH to below 5.5, thereby precipitating substantially pure A.sub.4.
Abstract: Compounds of the formula ##STR1## wherein R is phenyl, benzyl, 1-isopropylbenzyl wherein each of said aromatic rings may carry a chlorine substituent, ##STR2## R' is H, --C.tbd.N or --C.tbd.CH; R" is chlorine, bromine, fluorine or methyl; X and Y both but independently are H or loweralkyl; and Z is phenyl or benzyl which may carry an optional aromatic chlorine substituent, have been found to be excellent insecticides, ovicides and/or miticides.
Abstract: The addition of a 2-mercaptobenzamide to cutting fluid prevents bacterial and fungal growth.Concentrated solutions thereof in certain organic solvents are also disclosed. One such solution provides additional protection against corrosion of the metal surfaces.
Abstract: A triglyceride carrying, in the .beta.-position, the anionic moiety of phosphonoacetic acid has been found to exhibit excellent activity against viral infections caused by a herpes virus.
Abstract: An excellent catalyst for polyurethane foams is a combination of 1, 3, 5-tris(3-dimethyl-aminopropyl)-s-hexahydrotriazine and 2-(dimethylamino)-ethanol. It has unexpectedly been found that this catalyst combination produces both excellent gelation and blowing reactions.
Type:
Grant
Filed:
October 25, 1977
Date of Patent:
February 27, 1979
Assignee:
Abbott Laboratories
Inventors:
Daniel S. Raden, Morton A. Weiner, Douglas W. Hill
Abstract: N-(2-Methyl-1-naphthyl) maleimide has been found to be a potent biocide capable of protecting fabrics, plastics, paints, etc. from fungal and/or bacterial attack.
Abstract: Triglycerides carrying an anti-bacterial drug moiety in the 2-position and a hydrocarbon acyl moiety in the 1- and 3-positions exhibit excellent anti-bacterial properties without causing the side effects often associated with oral antibiotics when used by themselves.
Type:
Grant
Filed:
November 14, 1977
Date of Patent:
January 30, 1979
Assignee:
Abbott Laboratories
Inventors:
Gerald Y. Paris, Denis G. Cimon, David L. Garmaise
Abstract: N-Phenoxyphenyl or N-phenylthiophenyl maleimides or 2,3-dichloromaleimides carrying optional substituents in the phenyl rings are potent biocides capable of protecting fabrics and plastics from fungal or bacterial attacks.
Abstract: Paint compositions containing an industrial biocide can be prevented from yellowing by the addition of a small amount of a certain mercury salt.
Abstract: By the addition of a relatively small amount of N-(phenoxyphenyl)maleimide or the corresponding 3,4-dichloromaleimide, synthetic films or plastics or woven or knitted synthetic or cellulosic fabrics can be protected against fungal and bacterial deterioration.
Type:
Grant
Filed:
April 8, 1977
Date of Patent:
December 5, 1978
Assignee:
Abbott Laboratories
Inventors:
Frank C. Becker, Jorge P. Li, John W. Williams
Abstract: Protection against certain aquatic pests can be obtained by use of certain alkyl tin dithiocarbamates in the coating for materials exposed to such pests or the aquatic enivornment in contact with these materials.
Abstract: Prostaglandin type compounds of the formula ##STR1## wherein X is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-cis or--C.tbd.C--; Y is CH.sub.2 or O; Q is--CH.sub.2 --CH.sub.2 --or --CH.dbd.CH--; Z is H, OH, CH.sub.3 or CH.sub.2 OH, R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms or certain other moieties, and R" and R'''are H or CH.sub.3. These compounds are prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein Z, R, R" and Q have the above meaning and P is a removable protective group by condensation with a reactive moiety introducing the entire .alpha.-chain (R'''=CH.sub.3). If desired, the carbonyl function is subsequently reduced to W= --CH(OH)--. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.
Type:
Grant
Filed:
December 23, 1976
Date of Patent:
September 26, 1978
Assignee:
Abbott Laboratories
Inventors:
Andre G. Pernet, Hiromasa Nakamoto, Naoyasu Ishizuka
Abstract: This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.
Type:
Grant
Filed:
May 3, 1977
Date of Patent:
August 8, 1978
Assignee:
Abbott Laboratories
Inventors:
Peter H. Jones, Carroll W. Curs, Jaroslav Kyncl
Abstract: This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.
Type:
Grant
Filed:
May 3, 1977
Date of Patent:
August 8, 1978
Assignee:
Abbott Laboratories
Inventors:
Peter H. Jones, Carroll W. Curs, Jaroslav Kyncl
Abstract: A new chemical compound, the 12a-deoxychelocardin has been synthesized and found to be a potent antibacterial. It can also be used as an intermediate for the preparation of a number of modified chelocardin analogs that are similarly active as antibacterials, e.g. the compounds carrying different substituents in the D-ring.
Type:
Grant
Filed:
May 5, 1976
Date of Patent:
August 1, 1978
Assignee:
Abbott Laboratories
Inventors:
Edith Bernstein, Daniel Tim-Wo Chu, Stuart Nicholas Huckin
Abstract: This invention provides intermediates which are essential for a new chemical method which converts terrein, a fungal metabolite, to an intermediate which is known to be useful for the preparation of prostaglandins of the C series and analogs of other prostaglandins.
Type:
Grant
Filed:
July 22, 1976
Date of Patent:
July 25, 1978
Assignee:
The Ohio State University Research Foundation
Inventors:
Lester Allen Mitscher, George Winfred Clark, III, Gordon Herman Bokelman
Abstract: A compound represented by the formula ##STR1## wherein R is H, loweralkyl, hydroxyloweralkyl or ##STR2## where R.sub.2 is an alkyl group of 1 to 15 carbon atoms; and R.sub.1 is H or ##STR3## where R.sub.2 is an alkyl group of 1 to 15 carbon atoms. These compounds are useful as antischizophrenics.
Type:
Grant
Filed:
February 23, 1977
Date of Patent:
June 27, 1978
Assignee:
Abbott Laboratories
Inventors:
Bruce Wayne Horrom, Frederick Nelson Minard, Harold Elmer Zaugg
Abstract: This invention provides dibenzodiazepines represented by the formula ##STR1## wherein R is ##STR2## The compounds of this invention are useful as antischizophrenics.
Type:
Grant
Filed:
February 23, 1977
Date of Patent:
June 20, 1978
Assignee:
Abbott Laboratories
Inventors:
Bruce Wayne Horrom, William Douglas Barta
Abstract: The new blocked tripeptide Y-(N.sup.w -R')Arg-Pro-Gly-R wherein R is .[.hydroxy, methoxy or.]. amino, R' is a suitable blocking group and Y is hydrogen or an easily removable protective group has been found to be a valuable intermediate for the preparation of large peptide chains, such as for instance, the decapeptide Gn-RH.