Abstract: A method of treating herpes simplex infections in warm-blooded animals by administering to said animals a carboxylic ester of phosphonoacetic acid of the formula ##STR1## wherein R is a C.sub.1 -C.sub.2 alkyl.
Type:
Grant
Filed:
April 14, 1977
Date of Patent:
May 30, 1978
Assignee:
Abbott Laboratories
Inventors:
James Chieh-Hsia Mao, John Hunter Seely, John Scott Fairgrieve
Abstract: Covers a method for the control of mollusks by treating said mollusk or its habitat with a compound of the formula: ##STR1## where Z is selected from the group consisting of hydrogen, halo and cyano; X is selected from the group consisting of ##STR2## and Y is selected from the group consisting of halo, loweralkyl, aziridino, hydrogen, carboxyalkylthio, and cyano.
Abstract: This invention provides 2,4-diamino-5-benzylpyrimidines represented by the formula ##STR1## wherein R.sub.1 is H or loweralkyl; R.sub.2 is H, loweralkyl or R.sub.3 CO-- wherein R.sub.3 is H, alkyl, or cycloalkyl-lowerakyl; and X is a halogen; and the acid addition salts thereof.These pyrimidine compounds are useful as antibacterial agents, and as potentiators of the anti-bacterial activity of sulfonamides.
Type:
Grant
Filed:
October 26, 1976
Date of Patent:
May 2, 1978
Assignee:
Abbott Laboratories
Inventors:
Thomas John Perun, Ronald Robert Rasmussen, Bruce Wayne Horrom
Abstract: A compound of the formula ##STR1## wherein R is a C.sub.6 -C.sub.20 alkyl, arylalkyl or cycloalkyl alkyl; R' is phenyl or substituted phenyl; and X is H, halogen,N(R").sub.2where R" is H or C.sub.1 -C.sub.7 alkyl, or a group represented by the formula ##STR2## WHERE N IS AN INTEGER FROM 1 TO 4; M IS AN INTEGER FROM 1 TO 4; AND Y is CH.sub.2, O, S or NR"' where R"' is H or C.sub.1 -C.sub.7 alkyl.The compounds of this invention are useful as intraocular pressure lowering agents, i.e., anti-glaucoma agents.
Abstract: The use of catalytic amounts of pentamethyldipropylenetriamine promotes the formation of urethane links. Its unusual activity and properties makes the new compound very useful in the manufacture of flexible and rigid polyurethanes.
Abstract: 4-Tolyl diiodomethyl sulfone has been found to protect leather from fungal attack if it is incorporated into the tanning mixture in suitable amounts.
Type:
Grant
Filed:
September 20, 1976
Date of Patent:
March 14, 1978
Assignee:
Abbott Laboratories
Inventors:
Francis Walter Arbir, Frank Carl Becker
Abstract: This invention is directed to the method of combatting erythromycin sensitive bacteria in warm-blooded animals without restricting their food intake.
Type:
Grant
Filed:
December 13, 1976
Date of Patent:
February 28, 1978
Assignee:
Abbott Laboratories
Inventors:
Robert E. Singiser, Alexander Hing Chinn Chun, Shashi Pal Mehta
Abstract: Compounds of the formula ##STR1## and X is hydrogen, halo, alkyl, cyano or nitro, Y is oxygen or sulfur and R is lower alkyl, have been found to be excellent pesticides.
Abstract: Certain nonapeptide amides were found which, upon administration at daily dosages of from about 1-200 .mu.g/kg to warm-blooded animals, cause regression of DMBA-inducible or mammary tumors without causing adverse effects on healthy tissues.
Type:
Grant
Filed:
February 11, 1976
Date of Patent:
January 31, 1978
Assignee:
Abbott Laboratories
Inventors:
Edwin Samuel Johnson, John Hunter Seely
Abstract: Biodegradable insecticides having the formula: ##STR1## where X, Y and R are different, and X and Y are selected from the group consisting of hydrogen, halo, lower alkyl and lower alkoxy, and R is selected from the group consisting of nitrogen, oxygen, sulfur and sulfone.
Type:
Grant
Filed:
September 3, 1976
Date of Patent:
December 20, 1977
Assignee:
Abbott Laboratories
Inventors:
Robert George Stein, Terry Lee Couch, Aldo Joseph Crovetti
Abstract: A 4"-O-sulfonyl erythromycin derivative of the following structural formula: ##STR1## where R is selected from the group consisting of oxygen, oxime, and substituted oxime, R.sub.1 is hydrogen or hydroxy and R.sub.2 is selected from the group consisting of phthalimide, substituted amides, benzamides, substituted benzamides, sulfonamides, substituted sulfonamides, amines, substituted amines, phenylurea, substituted phenylurea, phenylthiourea, substituted phenylthiourea, thiophenol and substituted thiophenol, phenoxides and substituted phenoxides and R.sub.3 is hydrogen or methyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.
Type:
Grant
Filed:
June 12, 1975
Date of Patent:
December 13, 1977
Assignee:
Abbott Laboratories
Inventors:
Robert Hallas, Jerry Roy Martin, John Soloman Tadanier
Abstract: A two-step preparation of 3-arylpropyl chloride from the corresponding 2-chloropropiophenone by hydrogenation using two specific catalysts in series.
Abstract: Triglycerides carrying hydrocarbon acyl moieties in the 1- and 3-positions and the 2-methyl-1,3-benzodioxan-4-on-2-yl moiety in the 2-position exhibit excellent anti-inflammatory properties.
Abstract: A limited class of novel compounds, the 7-aza-11,12-dioxa-6-phenyl-tricyclo[7,2,1,0.sup.1.6 ]dodecanes carrying an optional alkyl substituent in the 7-position, has been found highly useful as injection anesthetics.
Abstract: With the administration of 1 .mu.g - 10mg/kg of specified nonapeptides, reproduction is prevented in warm-blooded animals of the reproductive age.
Type:
Grant
Filed:
March 1, 1976
Date of Patent:
July 5, 1977
Assignee:
Abbott Laboratories
Inventors:
Edwin Samuel Johnson, Wilfrid Francis White
Abstract: Excellent results have been obtained by reacting N-carboxyanhydrides of aminoacids with dopamine. This new route for making aminoacid derivatives of dopamine is advantageous as the aminoacid needs no blocking of the amino group and therefore no additional reaction step for the removal of such a blocking group.
Abstract: Biodegradable insecticides having the formula: ##STR1## where X, Y and R are different, and X and Y are selected from the group consisting of hydrogen, halo, lower alkyl and lower alkoxy, and R is selected from the group consisting of nitrogen, oxygen, sulfur and sulfone.
Type:
Grant
Filed:
April 7, 1975
Date of Patent:
May 24, 1977
Assignee:
Abbott Laboratories
Inventors:
Robert George Stein, Terry Lee Couch, Aldo Joseph Crovetti
Abstract: A process for preparing a peptide with His or 3-Me-His at the C-terminus wherein the coupling with said His or (3-Me) His is carried out in the presence of triethylamine.
Abstract: A dry chelocardin salt composition which is stable to extended storage periods comprises a mixture of monosodium chelocardin and between 0.2 and 2.0 parts of sodium citrate.