Patents Represented by Attorney Paul J. Cook

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  • Diafiltration method
    Patent number: 4728430
    Abstract: A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation: ##EQU1## called Equation 1.
    Type: Grant
    Filed: February 10, 1986
    Date of Patent: March 1, 1988
    Assignee: Millipore Corporation
    Inventors: Anthony J. DiLeo, Gaston de los Reyes, Lisa M. Waranch
  • Catalyst composition for effecting metathesis of olefins
    Patent number: 4727215
    Abstract: Compounds of the formula:M(NR.sup.1)(OR.sup.2).sub.2 (CHR.sup.3)whereinM is molybdenum or tungsten;R.sup.1 and R.sup.2 are alkyl, aryl, aralkyl or halogen-substituted derivatives or silicon-containing analogs thereof;R.sup.3 is an alkyl, aryl, aralkyl or any substituent that results from the initial reaction between the M.dbd.CHR.sup.3 complex and the olefin(s) that is(are) being metathesized;alkyl has 1-20 carbons, aryl has 6-20 carbons and aralkyl has 7-20 carbons.These compounds are catalysts for the metathesis of ordinary olefins (hydrocarbons) and especially functionalized olefins in the homogeneous phase.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: February 23, 1988
    Assignee: Massachusetts Institute of Technology
    Inventor: Richard R. Schrock
  • Metal coated laminate products made from textured polyimide film
    Patent number: 4725504
    Abstract: One or both surfaces of a uniformly and completely textured polyimide sheet are coated with a layer of electroless nickel or cobalt and a subsequent layer of electrolytically applied copper yielding an adhesiveless laminate useful in the production of electronic circuitry. The copper and nickel or cobalt layers are strongly bonded to the textured polyimide sheet to the extent that the laminate exceeds bond strength requirements as measured by current standard peel strength tests of the Institute for Interconnecting and Packaging Electronic Circuits (IPC) for both initial and post solder float adhesion.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: February 16, 1988
    Assignee: Polyonics Corporation
    Inventors: Philip D. Knudsen, Daniel P. Walsh
  • Zinc-aluminum alloy coatings for steel
    Patent number: 4722871
    Abstract: A zinc-aluminum alloy coating having desirable ductile properties and a uniform fine grain structure having excellent wettability for a ferrous metal substrate comprises greater than about 25 percent by weight aluminum and zinc, wherein the alloy further includes from about 0.1 to about 1.0 percent by weight of a rare earth alloy for enhancing the wettability of the alloy to the ferrous metal and the balance comprises additional additives and impurities. With alloys having increased concentration of aluminum, the solubility of the rare earth alloy is increased, thereby increasing wettability.
    Type: Grant
    Filed: August 14, 1986
    Date of Patent: February 2, 1988
    Assignee: Cosmos Engineering, Inc.
    Inventor: Schrade F. Radtke
  • Process for producing human antibodies
    Patent number: 4716111
    Abstract: Human antibodies are provided by collecting the mononuclear cells from human blood, removing suppressor T-cells and exposing the remaining lymphocyte cells to an antigen, autologous serum of the human patient and a nonspecific lymphocyte activator.
    Type: Grant
    Filed: January 30, 1985
    Date of Patent: December 29, 1987
    Assignee: Trustees of Boston University
    Inventors: Michal E. Osband, Joy A. Cavagnaro
  • Composition and method for increasing levels or release of brain serotonin
    Patent number: 4687763
    Abstract: A composition comprising tryptophan and melatonin with or without an insulin-releasing carbohydrate or melatonin and an insulin-releasing carbohydrate is administered to an animal in order to increase the levels or release of brain serotonin.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: August 18, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: Richard J. Wurtman
  • Analogues of actinomycin D
    Patent number: 4680382
    Abstract: Analogues of actinomycin D are provided which are effective in the therapeutic treatment of cancer.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: July 14, 1987
    Assignee: Trustees of Boston University
    Inventor: Sisir K. Sengupta
  • Use of hydrates for aqueous solution treatment
    Patent number: 4678583
    Abstract: A process for forming a purified solute from an aqueous solution is provided whereby a mixture of an extractant, a hydrate former and the aqueous solution is first formed. The hydrate former forms a hydrate with water while the solute does not form a hydrate. The extractant takes up the solute from the aqueous solution. The mixture is subjected to a temperature and pressure sufficient to form the solid hydrate of the hydrate former, an aqueous solution of the solute and a portion comprising the extractant containing the solute. The solute is recovered from the portion comprising the extractant and the solute.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: July 7, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard C. Willson, III, Eric Bulot, Charles L. Cooney
  • Detection and isolation of homologous, repeated and amplified nucleic acid sequences
    Patent number: 4675283
    Abstract: A novel method for detecting and isolating DNA sequences commonly held by different DNA preparations or repeated or amplified within a complex genome has been provided. The DNA preparations of interest are digested with the same restriction enzyme and a portion of at least one preparation is labeled with .sup.32 P. The labeled and unlabeled DNA preparations are combined and electrophoresed in an agarose gel. Following electrophoresis, the DNA is denatured in situ and allowed to reanneal within the gel so that homologous DNA sequences present within restriction fragments of the same size can reanneal. After reannealing, unhybridized single-stranded DNA is digested in situ followed by detection of the reannealed DNA by autoradiography. When labeled and unlabeled DNAs are derived from different DNA preparations, only the restriction fragments commonly held by these two preparations are detected.
    Type: Grant
    Filed: July 19, 1984
    Date of Patent: June 23, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: Igor Roninson
  • Multi-dose radio-isotope container
    Patent number: 4673813
    Abstract: A multi-dose container for radio-isotopes comprises a body having a cover. The cover contains a slidable portion which opens to reveal a small opening for withdrawing the contents of the container. The slidable portion is spring loaded and locks in the open position by engaging holding means formed on the cover. The cover contains a release bar which, when pressed, removes the holding means from engagement with the slidable portion and allows the spring to return the slidable portion to a closed position. The operation can easily be performed with one hand.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: June 16, 1987
    Assignee: Nuclear Medical Products, Inc.
    Inventor: Lawrence Sanchez
  • Method and composition for enhancing the effect of indirect-acting sympathomimetic amines
    Patent number: 4673689
    Abstract: Tyrosine or a tyrosine precursor is administered concomitantly with an indirect-acting sympathomimetic amine drug to increase the level of norepinephrine that can be released in sympathetic neuron synapses.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: June 16, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard J. Wurtman, Timothy J. Maher
  • Process for labeling amines with .sup.99m Tc
    Patent number: 4668503
    Abstract: Amines, including proteins and polypeptides covalently coupled with a chelating agent such as diethylenetriaminepentaacetic acid (DTPA) can be labeled with .sup.99m Tc in the presence of a stannous reducing agent at near neutral pH by maintaining the protein concentration at a low level and the DTPA concentration at a high level. The .sup.99m Tc is labeled to the protein through the DTPA sites linked to the protein. Utilizing .sup.111 In labeled proteins as controls, it is shown that the .sup.99m Tc labeled proteins are labeled at the DTPA sites and that they exhibit in vivo stabilities equal to that of the .sup.111 In labeled proteins.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: May 26, 1987
    Assignee: Trustees of University of Massachusetts
    Inventor: Donald Hnatowich
  • Process for producing product having patterned metal layer
    Patent number: 4666735
    Abstract: A multilayered composite product useful as an electrical circuit is produced by coating a base with a photoimagable resin free of catalyst or catalyst activator for electroless metal deposition. The resin is patterned by exposure to a desired light, through a mask followed by development. The patterned cured resin is selectively chemically modified while avoiding chemical modification of the base to render the cured resin receptive to a metal catalyst. The metal catalyst which promotes subsequent electroless metal deposition is selectively absorbed on the patterned cured resin and is converted to a catalytically active form. A conductive metal then is deposited selectively on the catalyst-containing patterned cured resin.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: May 19, 1987
    Assignee: Polyonics Corporation
    Inventors: Merwin F. Hoover, Ann B. Salamone, Jan Vandebult
  • Rapid method for determining the isoelectric point for amphoteric molecules
    Patent number: 4666855
    Abstract: A rapid method for determining the isoelectric point for an amphoteric molecule of interest is provided which utilizes the pH-dependent binding affinity of the molecule for an ion-exchange material. The empirically derived pI values are within a range of 0.2 pH units or less of the reported values in the literature and may be more precisely determined by employing a narrower pH gradient as part of the procedure. The unique methodology allows isoelectric point determinations to be accomplished within one hour's time, avoids carrier ampholyte interaction or artifact formation, and allows the determination to be performed at any desired temperature with decreased risk of denaturation.
    Type: Grant
    Filed: July 31, 1985
    Date of Patent: May 19, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Victor C. Yang, Robert S. Langer
  • Process for preventing or reversing cataract formation using protein modification reagents
    Patent number: 4665089
    Abstract: Cataract in mammalian lenses can be prevented or reversed by applying a solution of an imidoester, a N-hydroxysuccinimide-ester or hydrogen peroxide to the lens under conditions that permit the solution to interact with the lens constituents.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: May 12, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Roelant J. Siezen, Christophe M. Coppin, George B. Benedek
  • N.sup.2 (phenyl substituted) deoxy guanosine containing compounds
    Patent number: 4663446
    Abstract: New purine compounds having the formula: ##STR1## Y and Y'=H, ##STR2## X=H, alkyl, halo; ##STR3## A=O, S, NH.sub.2 are provided. These compounds are useful in treating patients having cancer, since they are potent and selective inhibitors of replicative DNA synthesis in mammalian cells since they inhibit DNA polymerase .alpha..New purine compounds also are provided having the formula: ##STR4## wherein Y, A, Z are as defined above, X'=C.sub.2 H.sub.5 Y"=--CH.sub.3 or ##STR5## These compounds are useful to prevent bacterial growth since they are potent inhibitors of DNA polymerase III.New Purine compounds also are provided having the formula: ##STR6## wherein Z' is H, OH or CH.sub.2 OH,A' is O of CH.sub.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: May 5, 1987
    Assignee: Trustees of the Univ. of Massachusetts
    Inventor: George E. Wright
  • Ultrasonically modulated polymeric devices for delivering compositions
    Patent number: 4657543
    Abstract: A composition such as a biologically active substance is delivered upon demand from a polymeric matrix by exposing the polymeric matrix containing the composition to ultrasonic energy.
    Type: Grant
    Filed: July 23, 1984
    Date of Patent: April 14, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, Joseph Kost
  • Apparatus for converting rotational motion to linear motion
    Patent number: 4648285
    Abstract: Apparatus is provided for converting rotational motion to linear motion which includes a screw shaft and nut surrounding the screw shaft, each having a helical thread. A plurality of threaded planetary rollers is interposed between and in contact with the threads of the screw shaft and nut. The screw shaft has a different number of starts than the number of starts on the nut.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: March 10, 1987
    Assignee: Millipore Corporation
    Inventor: William W. Carson
  • Method for treating depression with d-fenfluramine
    Patent number: 4649161
    Abstract: D-fenfluramine is administered to a human patient having seasonal depression or other forms of bipolar depression in order to alleviate or cure the depression.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: March 10, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard J. Wurtman, Judith J. Wurtman, Dermot O'Rourke
  • Integrated fuel-cell/steam plant for electrical generation
    Patent number: 4644751
    Abstract: An electrical generating plant of high efficiency utilizes a conventional steam plant powered by a fossil fuel such as coal, gas or oil, in internal integration with a high temperature solid-oxide fuel-cell. In one embodiment, the spent fuel and the wast heat from the fuel-cell of electrochemical action is made directly available to the combustion furnace of the steam plant for thermodynamic extraction. The system can achieve efficiencies up to 65% compared to ordinary steam plants which have an efficiency of about 35%.
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: February 24, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: Michael S. Hsu