Patents Represented by Attorney Paul J. Cook
  • Patent number: 4644075
    Abstract: Chiral borane reagents and their organosilicon derivatives are disclosed.
    Type: Grant
    Filed: December 9, 1985
    Date of Patent: February 17, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: Satoru Masamune
  • Patent number: 4643968
    Abstract: The metabolism and growth of cells is measured by suspending the cells in a liquid medium capable of forming a gel. The resultant suspension is formed into small droplets which droplets are caused to gel. Samples of the gel microdroplets (GMDs) are treated to alter the metabolism or growth of the cells, and the amount of metabolites, or other cellular products or external reaction products within each GMD is measured. The process can be utilized to determine essentially simultaneously the enumeration or count and the antibiotic susceptibility, or susceptibility to other compounds, factors, biological agents or other cells, of the cells which are representative of a larger sample of said cells.
    Type: Grant
    Filed: August 26, 1983
    Date of Patent: February 17, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: James C. Weaver
  • Patent number: 4642142
    Abstract: Mercury cadmium telluride (Hg.sub.1-x Cd.sub.x Te) is formed from an atmosphere of mercury vapor maintained at a temperature of within about 1.degree. C. of a desired temperature which contacts a liquid cadmium-tellurium solution with or without mercury maintained at a temperature within about 1.degree. C. of a desired temperature. The resultant mercury-cadmium-tellurium solution then is cooled to solidification.
    Type: Grant
    Filed: August 28, 1985
    Date of Patent: February 10, 1987
    Assignee: Massachusetts Institute of Technology
    Inventor: Theodore C. Harman
  • Patent number: 4638045
    Abstract: A novel bioerodible polymeric composition is provided comprising a plurality of monomer units of two or three amino acids which are polymerized via hydrolytically labile bonds at their respective side chains rather than at the amino or carboxylic acid terminals by amide bonds. Such polymers are useful for controlled release applications in vivo and in vitro for delivery of a wide variety of biologically and pharmacologically active ligands.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: January 20, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Joachim Kohn, Robert S. Langer
  • Patent number: 4636494
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: January 13, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Patent number: 4632745
    Abstract: An electrodeionization apparatus and process are provided for removing ions from liquids. Liquid to be purified is passed through depleting compartments containing mixed anion and cation exchange resin beads while a second liquid is passed through concentrating compartments free of ion exchange resin beads. Ions, under influence of a D.C. potential, pass from the depleting compartments into the concentrating compartments through ion permeable membranes. The beads in the depleting compartments are housed within subcompartments of controlled width and thickness and are retained therein by the ion permeable membranes which are secured to the walls of the subcompartments.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: December 30, 1986
    Assignee: Millipore Corporation
    Inventors: Anthony J. Giuffrida, Anil D. Jha, Gary C. Ganzi
  • Patent number: 4626527
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient who has or is about to participate in major exercise in order to decrease fatigue by increasing acetylcholine levels in the brain or other tissues. The term "fatigue" as used herein means the subjective feeling of tiredness as well as the fatigue of muscles and the actual decrease of performance.
    Type: Grant
    Filed: September 28, 1985
    Date of Patent: December 2, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard J. Wurtman, Lydia Conlay, Krzysztof Blusztajn
  • Patent number: 4626473
    Abstract: Thermal storage energy powders are formed from polyolefin particles having their surfaces crosslinked in a cold plasma. The crosslinked surfaces have a heat of fusion substantially identical to the uncrosslinked portion of the particles.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: December 2, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Ih-Houng Loh, Robert E. Cohen, Raymond F. Baddour
  • Patent number: 4624852
    Abstract: Choline or a choline precursor is administered to a patient together with an amino acid which is a precursor to a neurotransmitter in order to give a synergistic result for the two components.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: November 25, 1986
    Assignee: Massachusetts Institute of Technology
    Inventor: Richard J. Wurtman
  • Patent number: 4618533
    Abstract: A composite porous membrane is formed from a porous polymeric membrane having desired bulk properties on which is directly coated a cross-linked polymer having desired surface properties. The composites membrane retains the porosity of the porous polymeric membrane. A preferred composite porous membrane is formed from a porous polyvinylidene fluoride to which is directly coated with a polymer formed of a cross-linked hydroxyalkyl acrylate.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: October 21, 1986
    Assignee: Millipore Corporation
    Inventor: Michael J. Steuck
  • Patent number: 4614628
    Abstract: Solid oxide electrolyte structures, e.g., flat plates, suitable for use in an electrochemical energy converter are prepared by a plasma deposition technique. This process is comprised of forming a suspension of the oxide powders, passing the suspension through an arc discharge to melt the oxide particles and depositing the molten particles on a substrate. The deposited layer is allowed to cool and then is removed intact from the substrate. The plate then can be sintered and a fuel electrode material and an oxidizer electrode material can be applied on the opposing surfaces of the plate.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: September 30, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael S. Hsu, Charles F. Wilson
  • Patent number: 4610790
    Abstract: Water substantially free of pyrogens and microorganisms that meets the requirements of United States Pharmacopoeia Standard USP XX Water for Injection is produced by processing drinking quality water through a filtration step adapted to remove organic contaminants and impurities that degrade downstream seperation membranes, a reverse osmosis step to remove dissolved solids, pyrogens, microorganisms and chemical contamination, a deionization step to further remove dissolved solids, and an ultrafiltration step to remove pyrogens. A sterile filter to remove microorganisms increases the water quality to USP XX Sterile Water for Injection. Means are provided to periodically remove accumulated chemical contaminants, pyrogens and microorganisms from the reverse osmosis apparatus, the deionization apparatus and the ultrafiltration apparatus. The sterile water can be admixed with a sterile concentrate composition to produce a sterile dilute solution that can be packaged under sterile conditions.
    Type: Grant
    Filed: February 10, 1984
    Date of Patent: September 9, 1986
    Assignee: Sterimatics Company Limited Partnership
    Inventors: Adrian R. Reti, James A. Benn
  • Patent number: 4609647
    Abstract: Cytidyl diphosphocholine is administered to a patient alone to increase brain acetylcholine levels or concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: September 2, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Patent number: 4608309
    Abstract: A thermal energy storage composition is provided comprising a slurry of polyolefin particles in a liquid. The particles have their surfaces crosslinked in a cold plasma so that the crosslinked surfaces have a heat of fusion substantially identical to the uncrosslinked portion of the particles.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: August 26, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Ih-Houng Loh, Robert E. Cohen, Raymond F. Baddour
  • Patent number: 4600696
    Abstract: A process and kit are provided for measuring chemical and physical stresses on the blood platelets of a human patient by measuring reduction in ATP (adenosine triphosphate) and ADP (adenosine diphosphate) concentrations while measuring increases in the ATP degradation products HYPX (hypoxanthine) and AMP (adenosine monophosphate). The process is useful for measuring a human patient's risk to internal stress such as reduction in the size of blood vessels, to response to various environmental changes as well as to a variety of treatments including drug treatment, risk of malignant hyperthermia in response to anesthetic administration or in response to vascular or organ transplant.
    Type: Grant
    Filed: June 22, 1984
    Date of Patent: July 15, 1986
    Inventor: Clive C. Solomons
  • Patent number: 4598094
    Abstract: Tyrosine or a tyrosine precursor is administered concomitantly with an indirect-acting sympathomimetic amine drug to increase the level of norepinephrine that can be released in sympathetic neuron synapses.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: July 1, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard J. Wurtman, Timothy J. Maher
  • Patent number: 4594084
    Abstract: The present invention comprises an axial flow compressor and an impeller in fluid communication on a common rotatable shaft with an inlet fan and drive pulley. The compressor and impeller are each dischargeable into a cooling-heating tube. An air separation device at the downstream end of the cooling-heating tube draws cool air from the axially central part of the cooling-heating tube, and it draws hot air from adjacent the inner walls of the cooling-heating tube. The different streams of air may be selectively conducted to the interior of an automobile to function as an air conditioner, a defroster or the like. The compressor, impeller and inlet fan may be empowered by rotative means such as an automobile engine.
    Type: Grant
    Filed: July 15, 1985
    Date of Patent: June 10, 1986
    Assignee: Astrl Corporation
    Inventor: Wallace Lopez
  • Patent number: 4593050
    Abstract: Fluorinated polymer surfaces are provided by a process in which ultraviolet radiation is used to assist the surface fluorination reaction.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: June 3, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert E. Cohen, George C. Corbin, Raymond F. Baddour
  • Patent number: 4591496
    Abstract: A new method for making polymeric systems for the sustained release of macromolecular drugs is described. The method consists of mixing drug and polymer, e.g. ethylene-vinyl acetate copolymer powders below the glass transition temperature of the polymer, and compressing the mixture at a temperature above the glass transition point. The macromolecule is not exposed to organic solvent during the fabrication process. The sustained release and bioactivity of macromolecules is unchanged throughout the pressure casting and release processes.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: May 27, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Jonathan M. Cohen, Ronald Siegel, Robert Langer
  • Patent number: 4583099
    Abstract: A resonant tag circuit is provided which is useful in conjunction with an electronic security system for preventing theft of articles from a protected area. The tag circuit comprises an electrically insulating substrate having a spiral conductive path on each surface of the substrate. The spiral conductive paths are positioned to overlap each other to effect distributed capacitance. The degree of overlap of the distributed capacitance portion of the conductive paths is such that it provides at least 70%, preferably 90% and most preferably 100% of the total overlapping portions of the circuit.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: April 15, 1986
    Assignee: Polyonics Corporation
    Inventors: Phillip B. Reilly, Jan Vandebult