Patents Represented by Attorney, Agent or Law Firm Paul W. Zimmerman
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Patent number: 6150155Abstract: The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.Type: GrantFiled: September 16, 1999Date of Patent: November 21, 2000Assignee: Battelle Memorial InstituteInventors: Raymond E. Wildung, Thomas R. Garland, Shu-Mei W. Li
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Patent number: 6134289Abstract: According to the present invention, a system for measuring a thermal neutron emission from a neutron source, has a reflector/moderator proximate the neutron source that reflects and moderates neutrons from the neutron source. The reflector/moderator further directs thermal neutrons toward an unmoderated thermal neutron detector.Type: GrantFiled: May 1, 1998Date of Patent: October 17, 2000Assignee: Battelle Memorial InstituteInventors: Anthony J. Peurrung, David C. Stromswold
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Patent number: 6129973Abstract: The present invention is a microchannel mass exchanger having a first plurality of inner thin sheets and a second plurality of outer thin sheets. The inner thin sheets each have a solid margin around a circumference, the solid margin defining a slot through the inner thin sheet thickness. The outer thin sheets each have at least two header holes on opposite ends and when sandwiching an inner thin sheet. The outer thin sheets further have a mass exchange medium. The assembly forms a closed flow channel assembly wherein fluid enters through one of the header holes into the slot and exits through another of the header holes after contacting the mass exchange medium.Type: GrantFiled: September 26, 1997Date of Patent: October 10, 2000Assignee: Battelle Memorial InstituteInventors: Peter M. Martin, Wendy D. Bennett, Dean W. Matson, Donald C. Stewart, Monte K. Drost, Robert S. Wegeng, Joseph M. Perez, Xiangdong Feng, Jun Liu
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Patent number: 6126723Abstract: The present invention is a fundamental method and apparatus of a microcomponent assembly that overcomes the inherent limitations of state of the art chemical separations. The fundamental element enabling miniaturization is the porous contactor contained within a microcomponent assembly for mass transfer of a working compound from a first medium to a second medium. The porous contactor has a thickness, and a plurality of pores extending through the thickness. The pores are of a geometry cooperating with a boundary tension of one or the other or both of the media thereby preventing migration of one, other or both through the microporous contactor while permitting passage of the working compound. In the microcomponent assembly, the porous contactor is placed between a first laminate such that a first space or first microplenum is formed between the microporous contactor and the first laminate. Additionally, a cover sheet provides a second space or second plenum between the porous contactor and the cover sheet.Type: GrantFiled: June 10, 1998Date of Patent: October 3, 2000Assignee: Battelle Memorial InstituteInventors: Monte K. Drost, Robert S. Wegeng, Michele Friedrich, William T. Hanna, Charles J. Call, Dean E. Kurath
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Patent number: 6118039Abstract: The present invention is a process wherein superoxide radicals from superoxide salt are used to break down the explosive compounds. The process has an excellent reaction rate for degrading explosives, and operates at ambient temperature and atmospheric pressure in aqueous or non-aqueous conditions. Because the superoxide molecules are small, much smaller than an enzyme molecule for example, they can penetrate the microstructure of plastic explosives faster. The superoxide salt generates reactive hydroxyl radicals, which can destroy other organic contaminants, if necessary, along with digesting the explosive nitro-bearing compound.Type: GrantFiled: April 2, 1999Date of Patent: September 12, 2000Assignee: Battelle Memorial InstituteInventor: Manish M. Shah
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Patent number: 6113993Abstract: The present invention is a method of coating a substrate with a calcium phosphate compound using plasma enhanced MOCVD. The substrate is a solid material that may be porous or non-porous, including but not limited to metal, ceramic, glass and combinations thereof. The coated substrate is preferably used as an implant, including but not limited to orthopaedic, dental and combinations thereof. Calcium phosphate compound includes but is not limited to tricalcium phosphate (TCP), hydroxyapatite (HA) and combinations thereof. TCP is preferred on a titanium implant when implant resorbability is desired. HA is preferred when the bone bonding of new bone tissue into the structure of the implant is desired. Either or both of TCP and/or HA coated implants may be placed into a solution with an agent selected from the group of protein, antibiotic, antimicrobial, growth factor and combinations thereof that can be adsorbed into the coating before implantation.Type: GrantFiled: October 28, 1998Date of Patent: September 5, 2000Assignee: Battelle Memorial InstituteInventors: Yufei Gao, Allison A. Campbell
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Patent number: 6108081Abstract: The present invention is a method and apparatus for microscopic vibrational imaging using coherent Anti-Stokes Raman Scattering or Sum Frequency Generation. Microscopic imaging with a vibrational spectroscopic contrast is achieved by generating signals in a nonlinear optical process and spatially resolved detection of the signals. The spatial resolution is attained by minimizing the spot size of the optical interrogation beams on the sample. Minimizing the spot size relies upon a. directing at least two substantially co-axial laser beams (interrogation beams) through a microscope objective providing a focal spot on the sample; b. collecting a signal beam together with a residual beam from the at least two co-axial laser beams after passing through the sample; c. removing the residual beam; and d. detecting the signal beam thereby creating said pixel.Type: GrantFiled: April 19, 1999Date of Patent: August 22, 2000Assignee: Battelle Memorial InstituteInventors: Gary R. Holtom, Xiaoliang Sunney Xie, Andreas Zumbusch
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Patent number: 6106675Abstract: The method of the present invention is a microwave bond cleavage of a first hydrocarbon compound, the first hydrocarbon compound in a liquid phase and substantially non-aqueous, to a second compound having a shorter carbon chain than the first hydrocarbon compound. The method has the steps of exposing a combination of the first hydrocarbon compound with a supported catalyst having a carrier of a non-metallic amorphous solid with at least one catalytic metal dispersed therein to microwave energy thereby converting the first hydrocarbon compound into the second hydrocarbon compound, and recovering the second hydrocarbon compound. Advantages of the present invention include use of a low cost supported catalyst at ambient temperature and pressure.Type: GrantFiled: July 24, 1998Date of Patent: August 22, 2000Assignees: Battelle Memorial Institute, Governors of the University of AlbertaInventors: Dennis D. Tanner, Qizhu Ding, Pramod Kandanarachchi, James A. Franz
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Patent number: 6103528Abstract: A gelling cell culture medium useful for forming a three dimensional matrix for cell culture in vitro is prepared by copolymerizing an acrylamide derivative with a hydrophilic comonomer to form a reversible (preferably thermally reversible) gelling linear random copolymer in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff, mixing the copolymer with an aqueous solvent to form a reversible gelling solution and adding a cell culture medium to the gelling solution to form the gelling cell culture medium. Cells such as chondrocytes or hepatocytes are added to the culture medium to form a seeded culture medium, and temperature of the medium is raised to gel the seeded culture medium and form a three dimensional matrix containing the cells. After propagating the cells in the matrix, the cells may be recovered by lowering the temperature to dissolve the matrix and centrifuging.Type: GrantFiled: April 17, 1998Date of Patent: August 15, 2000Assignees: Battelle Memorial Institute, Medical University of South CarolinaInventors: Yuehuei H. An, Vladimir A. Mironov, Anna Gutowska
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Patent number: 6082181Abstract: The present invention is an ultrasonic liquid densitometer that uses a material wedge having two sections, one with a liquid/wedge interface and another with a gas/wedge interface. It is preferred that the wedge have an acoustic impedance that is near the acoustic impedance of the liquid, specifically less than a factor of 11 greater than the acoustic impedance of the liquid. Ultrasonic signals are internally reflected within the material wedge. Density of a liquid is determined by immersing the wedge into the liquid and measuring reflections of ultrasound at the liquid/wedge interface and at the gas/wedge interface.Type: GrantFiled: October 21, 1998Date of Patent: July 4, 2000Assignee: Battelle Memorial InstituteInventor: Margaret S. Greenwood
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Patent number: 6082180Abstract: The present invention is an ultrasonic fluid densitometer that uses at least one pair of transducers for transmitting and receiving ultrasonic signals internally reflected within a material wedge. A temperature sensor is provided to monitor the temperature of the wedge material. Density of a fluid is determined by immersing the wedge into the fluid and measuring reflection of ultrasound at the wedge-fluid interface and comparing a transducer voltage and wedge material temperature to a tabulation as a function of density.Type: GrantFiled: October 21, 1998Date of Patent: July 4, 2000Assignee: Battelle Memorial InstituteInventor: Margaret S. Greenwood
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Patent number: 6067861Abstract: According to the present invention, a method and apparatus rely upon tomographic measurement of the speed of sound and fluid velocity in a pipe. The invention provides a more accurate profile of velocity within flow fields where the speed of sound varies within the cross-section of the pipe. This profile is obtained by reconstruction of the velocity profile from the local speed of sound measurement simultaneously with the flow velocity. The method of the present invention is real-time tomographic ultrasonic Doppler velocimetry utilizing a to plurality of ultrasonic transmission and reflection measurements along two orthogonal sets of parallel acoustic lines-of-sight. The fluid velocity profile and the acoustic velocity profile are determined by iteration between determining a fluid velocity profile and measuring local acoustic velocity until convergence is reached.Type: GrantFiled: June 18, 1998Date of Patent: May 30, 2000Assignee: Battelle Memorial InstituteInventors: Alireza Shekarriz, David M. Sheen
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Patent number: 6046039Abstract: The present invention is an improved method of making a partially modified PCR product from a DNA fragment with a polymerase chain reaction (PCR). In a standard PCR process, the DNA fragment is combined with starting deoxynucleoside triphosphates, a primer, a buffer and a DNA polymerase in a PCR mixture. The PCR mixture is then reacted in the PCR producing copies of the DNA fragment. The improvement of the present invention is adding an amount of a modifier at any step prior to completion of the PCR process thereby randomly and partially modifying the copies of the DNA fragment as a partially modified PCR product. The partially modified PCR product may then be digested with an enzyme that cuts the partially modified PCR product at unmodified sites thereby producing an array of DNA restriction fragments.Type: GrantFiled: August 19, 1998Date of Patent: April 4, 2000Assignee: Battelle Memorial InstituteInventor: Kwong-Kwok Wong
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Patent number: 6015869Abstract: The present invention is a sorbent polymer with the (AB)n sequence where the fluorinated interactive A segment is fluoroalkyl-substituted bisphenol and the oligosiloxane B segment is an oligodimethylsiloxane. More specifically, the fluoroalkyl-substituted bisphenol contains two allyl groups and the oligodimethylsiloxane has terminal Si--H groups. The sorbent polymer may be used as thin films on a variety of chemical sensors, or as a component of a thin film on a chemical sensor. Crosslinked sorbent polymers are processable into stable thin films on sensor devices. Sorbent polymers are also useful in sensor arrays, in surface acoustic wave sensors, and in cladding of optical fibers. Sensor arrays provide better selectivity than single sensors and permit identification and quantification of more than one species in a mixture. The sorbent polymer is synthesized by hydrosilylation polymerization which is achieved by catalyzed heating.Type: GrantFiled: March 17, 1998Date of Patent: January 18, 2000Assignee: Battelle Memorial InstituteInventors: Jay W. Grate, Steven N. Kaganove
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Patent number: 6014024Abstract: The present invention uses a magnet and sensor coil unilaterial and in relative motion to a conductive material, to measure perturbation or variation in the magnetic field in the presence of a flaw. A liftoff compensator measures a distance between the conductive material and the magnet.Type: GrantFiled: March 17, 1998Date of Patent: January 11, 2000Assignee: Battelle Memorial InstituteInventors: Ronald L. Hockey, Douglas M. Riechers
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Patent number: 6011193Abstract: A treatment method for containers of hazardous materials, including chemical and conventional weapons, is described. The method is applicable to munitions containing explosives and chemical warfare agents, and to training or test rounds. The containers are subjected to a highly corrosive fluid which dissolves all or part of the container and renders the containers useless as munitions. The highly corrosive fluid may render the hazardous material non-hazardous. The result of the treatment is a liquor which can undergo further treatment for recovery or disposal.Type: GrantFiled: June 20, 1997Date of Patent: January 4, 2000Assignee: Battelle Memorial InstituteInventors: Craig A. Myler, Martin E. Toomajian, Monte R. Elmore, Evan O. Jones, Alan H. Zacher
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Patent number: 5993633Abstract: The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.Type: GrantFiled: July 31, 1997Date of Patent: November 30, 1999Assignee: Battelle Memorial InstituteInventors: Richard D. Smith, Joanne C. Severs
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Patent number: 5990416Abstract: The present invention is a method for reducing a dopant in a film of a metal oxide wherein the dopant is reduced and the first metal oxide is substantially not reduced. The method of the present invention relies upon exposing the film to reducing conditions for a predetermined time and reducing a valence of the metal from a positive valence to a zero valence and maintaining atoms with a zero valence in an atomic configuration within the lattice structure of the metal oxide. According to the present invention, exposure to reducing conditions may be achieved electrochemically or achieved in an elevated temperature gas phase.Type: GrantFiled: April 16, 1998Date of Patent: November 23, 1999Assignee: Battelle Memorial InstituteInventors: Charles F. Windisch, Jr., Gregory J. Exarhos
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Patent number: 5986452Abstract: The present invention is an improved sensing unit for detecting flaws in conductive material wherein the sensing coil is positioned away from a datum of either the datum point, the datum orientation, or a combination thereof. Position of the sensing coil away from a datum increases sensitivity for detecting flaws having a characteristic volume less than about 1 mm.sup.3, and further permits detection of subsurface flaws. Use of multiple sensing coils permits quantification of flaw area or volume.Type: GrantFiled: December 2, 1997Date of Patent: November 16, 1999Assignee: Battelle Memorial InstituteInventors: Ronald L. Hockey, Douglas M. Riechers
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Patent number: 5985304Abstract: A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of time.Type: GrantFiled: February 25, 1998Date of Patent: November 16, 1999Assignee: Battelle Memorial InstituteInventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton