Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.

Abstract: Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV am disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.

Abstract: The present invention relates to the field of human health, and more particularly to the treatment of attention deficit/hyperactivity disorder (ADHD) with mazindol. The latter can be administered as monotherapy or in combination with one or more compounds, including psychostimulants, for the indication of ADHD and associated or co-morbid symptoms.

Abstract: The present invention is seen to provide a new methodology, testing system designs and concept to enable in situ real time monitoring of the cure process. Apparatus, system, and method for the non-destructive, in situ monitoring of the time dependent curing of advanced materials using one or more differential ultrasonic waveguide cure monitoring probes. A differential ultrasonic waveguide cure monitoring probe in direct contact with the material to be cured and providing in situ monitoring of the cure process to enable assessment of the degree of cure or cure level in a non-cure related signal variances (e.g., temperature) independent calibrated response manner. A differential ultrasonic waveguide cure monitoring probe including a transducer coupled to a waveguide and incorporating correction and calibration methodology to accurately and reproducibly monitor the cure process and enable assessment of cure level via ultrasonic reflection measurements.

Abstract: A system and method of determining point-of-purchase placement locations for printed promotional materials on a retail structure includes loading, by a processing device from a database, data representative of a retail structure; determining a plurality of advertisement placement locations on the retail structure; determining a point-of-placement priority value for each of the plurality of advertisement placement locations; receiving an advertising campaign comprising data representing a plurality of advertising campaign items, each item including an associated item priority value; determining a location on the retail structure for each of the advertising campaign items based upon the item priority values and the point-of-placement priority values; and providing a report to an operator of the retail structure indicating where each of the advertising campaign items is to be displayed on the retail structure.

Abstract: A customizable costume designed to look like a magazine cover and to be worn by a wearer such that the wearer appears to be a part of the magazine cover. The costume includes a panel having a hole cut therethrough, a plurality of attachment points and at least one channel disposed on at least one edge of the panel, at least one flexible strap passing through the plurality of attachment points configured to affix the costume to the wearer, and an internal frame affixed to the panel in the at least one channel, the frame configured to provide rigid support for the panel.

Abstract: A method of structuring ownership of an invention including the steps of receiving an investment commitment and a capital contribution from at least one investor, investing the capital contribution in a portfolio company, assigning a set of securities to the at least one investor based upon the capital contribution, the set of securities comprising a plurality of strips, and providing one or more of the plurality of strips to the at least one investor, wherein each of the plurality of strips is defined as a portion of the capital contribution and wherein at least one of the strips is dedicated for donation by the investor to at least one charity.

Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.

Abstract: Methods for detecting proteases by contacting a sample to be assayed with a substrate at least partially coated with a film of a synthetic polymeric matrix, and measuring a signal output of the substrate is provided herein.

Abstract: This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl) cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1?,2?,3?(1S*,2R*),5?]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.

Abstract: Training devices for facilitating proper bow holds on bow sticks of bowed stringed instruments. An exemplary training device may include a fingers stabilizer having a body with one or more thumb opening walls that define a thumb opening in the body. The thumb opening walls and/or the thumb opening may guide a thumb to the bow stick and position an end of the thumb at an approximate intersection of a bow stick frog and a bow stick shaft. The body may also include a finger separator that helps position an index finger and a middle finger on the bow stick. The fingers stabilizer may also have contact areas for positioning a ring finger and a pinky finger on the bow stick.

Abstract: A method for modeling of an overhead electrical conductor, includes: collecting 3-dimensional location data of the conductor; substantially simultaneous with said collecting, acquiring a thermal measurement of the conductor with a local thermal sensor; and generating a CAD model of the conductor using the collected 3-dimensional location data of the conductor and the thermal measurement of the conductor. The CAD model facilitates thermal line analysis of the conductor, thermal rating of a power line that includes the conductor, clearance analysis relative to the conductor, and vegetation management relative to the conductor.

Abstract: The present invention relates to a liquid pipe unblocker comprising at least one strong acid, and a colored indicator capable of assuming different colors, depending on the acid concentration and on the polarity of the pipe unblocker solution.

Abstract: A method for locating a stem of a target tree is disclosed. The target tree is identified from a sensing dataset. At least one slice is created from the sensing dataset. The at least one slice includes at least a portion of the target tree. A tree stem location of the target tree is determined from the at least one slice. A system for locating a stem of a target tree is also disclosed. The system has a processor configured to implement the described method. The system also has a data input coupled to the processor and configured to provide the processor with the sensing dataset. The system further has a user interface coupled to either the processor or the data input.

Abstract: The present invention relates to a laser beam control structure and method. A laser beam control structure of the present invention comprises a handpiece for irradiating laser beams output from a laser beam output device, on a predetermined part; at least one electrode unit positioned at a human body contact portion of the handpiece and receiving hum noise generated from a human body; and a control unit electrically connected to the electrode unit so as to measure the hum noise applied from the electrode unit and to cause the laser beams to be irradiated according to the measured hum noise. According to the present invention, there are advantages in that various types of hum noise generated from a human body are measured without applying an electric current to the human body, and a laser beam is irradiated according to the measured hum noise.

Abstract: Air purification systems comprising a plurality of disks, and methods for their use, are provided. Each of the plurality of disks comprises a metal substrate, an undercoat layer disposed on the metal substrate, a photosensitive layer disposed on the undercoat layer, and a charge transfer layer disposed on the photosensitive layer.

Abstract: A method of measuring the sales performance of a dealer may include determining a propensity to buy score associated with each lead received by a dealer and determining an expected close rate associated with the dealer that may be based on the determined propensity to buy scores. The method may also include determining, by a computing device, an effectiveness rate associated with the dealer that may be based on at least the expected close rate and an actual close rate.

Abstract: Embodiments herein describe a composition including at least one water-soluble complex having a water-soluble separation agent including a planar portion, at least one pi electron on the planar portion and at least one electron withdrawing group; and a semiconducting single-walled carbon nanotube in an aqueous solution. Further embodiments describe a method of separating metallic single-walled carbon nanotubes and semiconducting single-walled carbon nanotubes including providing carbon nanotubes having an admixture of semiconducting single-walled carbon nanotubes and metallic single-walled carbon nanotubes; and combining the admixture with a water-soluble separation agent in an aqueous solution to form a mixture, in which the water-soluble separation agent includes a planar portion, at least one pi electron on the planar portion and at least one electron withdrawing group.

Abstract: Techniques are disclosed that minimize the effect of an external force on peripheral devices attached to a host machine (e.g., vending and gaming machines). The techniques include using long spacers that are designed to be close to the rear of a machine so that in the event of a vandalism attack on the front of the machine, a peripheral device attached to the machine, such as a bill acceptor, transfers the external force to the back of the machine. Once the force is transferred, the force is distributed over a robust surface. The techniques also include use of a cradle assembly and a fixed housing to mount peripheral devices in machines that also minimize the effect of an external force on peripheral devices mounted to machines.