Abstract: Methods for treating type 1 diabetes mellitus or a condition resulting from the loss of pancreatic islet cells in a patient are disclosed herewith. The method of treatment comprises co-administration of human proislet peptides (HIP); and an agent that inhibits the activity of autoimmune cells.

Abstract: A heater with 360° rotation of a heated air stream is provided. The device includes a housing, a motor, an impeller, a heating element, an air stream deflector and a rotational engine. More specifically, the device is directed toward a portable space heater having an outward radial projection of a heated air stream in combination with 360° rotational movement for reducing air temperature stratification and uneven heating problems in a room.

Abstract: Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.

Abstract: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond.

Abstract: Provided are methods for the treatment of disorders of the central nervous system (CNS) and the eye. In particular, use of compositions comprising a compound capable of modulating a target gene or gene product is described for the preparation of a pharmaceutical composition for the treatment of disorders of the CNS and/or the eye, wherein the composition is designed to be administered outside the blood-CNS and the blood-retina barriers. Furthermore, methods are provided for identifying and obtaining nucleic acid molecules encoding polypeptides involved in CNS disorders or of the eye, methods for diagnosing said disorders as well as transgenic animal deficient in the expression of target genes identified in accordance with the described method. In addition, methods of identifying and isolating drugs that are particularly useful for the treatment of disorders related to the CNS and/or the eye are disclosed.

Abstract: A method of measuring pressure for a cell in a pneumatic compression device may include performing an inflate/exhaust cycle including, for one or more cells of a plurality of cells in a pneumatic compression device, inflating a cell to a target pressure, wherein the target pressure is based on at least a desired pressure, measuring a pressure of the cell, determining an overpressure value associated with the cell based on at least the measured pressure, determining a subsequent target pressure associated with the cell based on at least the measured pressure and the overpressure value, deflating the cell, and inflating the cell until the subsequent target pressure is achieved.

Abstract: A method and apparatus for determining position and rotational orientation of an object within a predetermined area is disclosed. Position markers, encoded with their identity, are viewed with a camera, images are captured and processed, and the position and rotational orientation of the object are calculated. Three embodiments are disclosed; the first having a camera mounted on the movable object while position markers bearing linear bar codes are fixed in location, the second having a camera mounted on the movable object while position markers bearing two-dimensional bar codes are fixed in location, and the third having a position marker of either type affixed to the object while the camera is fixed in location.

Abstract: A remote access client is provided for enabling communication between a remote data terminal configured to access a public network, and an enterprise network by way of a VPN tunnel through the public network. The remote access client includes at least one application program interface (API) to receive a first verification of the operating state of a predetermined application of the remote data terminal to enable a connection agent for establishing a point of presence on the public network. Upon connection to the point of presence, the API exchanges data between the remote access client and the predetermined application of the remote data terminal. The remote access client receives a second periodic verification of the operating state of the predetermined application via the API for terminating the connection to the point of presence upon the absence of the second verification.

Abstract: A method of semantically classifying a data set of open class nouns and a system for executing the method. The method includes loading, by a processing device, a data set comprising one or more open class nouns from a computer readable medium operably connected to the processing device; extracting, by the processing device, the one or more open class nouns from the data set; for each open class noun, querying, by the processing device, one or more application programming interfaces (APIs) to produce one or more results; deriving, by the processing device, a confidence score for the data set based upon the one or more results; and determining, by the processing device, a classification for the data set based upon the derived confidence score.

Abstract: RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

Abstract: An indicator, such as an alarm or warning, is generated to indicate that a document storage cassette attached to a document handling device (e.g., a currency validator) has reached a particular capacity or is approaching its full capacity.

Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.

Abstract: Techniques for dyeing material are disclosed, including providing a magnetorheological fluid containing a coloring agent onto a contacting surface, applying a magnetic field to the magnetorheological fluid to increase viscosity of the magnetorheological fluid, and contacting the material with the magnetorheological fluid on the contacting surface to dye the material with the coloring agent.

Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.

Abstract: The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.

Abstract: Pneumatic compression devices and methods for using the same are disclosed. A pneumatic compression device may include a compression pump, a fill/exhaust valve, a transducer, a plurality of cell valves, and a controller. The compression pump may output a pressurized fluid via an output. The fill/exhaust valve may connect one or more cell valves to the compression pump when in an open state and to the atmosphere when in a closed state. The transducer may sense a pressure level. Each cell valve may correspond to a cell and may connect the fill/exhaust valve to the corresponding cell when in an open state. The controller may determine a state (either open or closed) for each of the fill/exhaust valve and the plurality of cell valves based on at least the pressure level sensed by the transducer.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.

Abstract: A banknote validator takes both reflection and transmission optical measurements at different wavelengths. An emitter and sensor on one side of the banknote path are used to make a calibration measurement using light reflected from a window on the other side of the path, overlying another optical device. Each measurement is normalized on the basis of multiple measurements of different wavelengths, distributed over a substantial area, such as along the relevant scan line, preferably using a value representing the dispersion of the measurements.

Abstract: A system for locking and unlocking containers to transport modes and other containers comprises an actuating unit in an upper corner fitting of a container, a mechanical connecting mechanism connected to the actuating unit, and guides to route the connecting mechanism from the actuating unit to a rotatable locking leg housed in a lower corner fitting of the container. The twist lock of a lifting spreader engages the upper corner fitting of a container, urging the actuating unit. The connecting mechanism is in turn urged thereby causing the locking leg to rotate. The locking system, and apparatus to unlock a container twistlock, comprises in addition to an actuating unit, a locking mechanism in a lower corner fitting of the container, and a vertical coupler connecting the actuating unit with the locking mechanism.