Abstract: A method and system of embossing ink including applying the ink to a print substrate, applying an embossing substrate to the ink wherein the embossing substrate imprints a predetermined pattern into the ink, and curing, via a radiation source, the ink such that an imprint of the predetermined pattern is embossed in the ink.

Abstract: A method of processing a print job in a document production environment includes receiving a job ticket having job ticket parameters, identifying a process plan template having processing instructions for processing the print job and performing a parameter value resolving process for each job ticket parameter. The resolving process may include identifying candidate values, identifying the source associated with each of the candidate values and determining whether a candidate value has a source having precedence. If a source has precedence, the corresponding candidate value may be selected as a resolved parameter value. A user may be presented with a representation of a set of the resolved parameter values and may be permitting to modify at least one of the resolved parameter values. A first portion of the print job may be processed using the identified process plan template, the resolved parameter values, and any user-modified parameter values.

Abstract: An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.

Abstract: A system and method for routing and processing jobs in a production environment considers the setup characteristics of each print job. Each set of jobs may be classified as a first job processing speed set, a second job processing speed set, or another job processing speed set based on the corresponding setup characteristics. First job processing speed sets are routed to a first group of job processing resources, while second job processing speed sets are routed to a second group of job processing speed resources. Each resource group may include an autonomous cell.

Abstract: A magnetic resonance imager performing images of a patient imager includes imaging coils. The imager includes receiver coils The imager includes a computer that causes the imaging coils to produce a first steady-state free precession excitation slab with respect to a first position regarding a target of the patient during a first repetition time, and a second steady-state free precession excitation slab with respect to a second position different from the first position regarding the target during a second repetition time; and forming a first 3-D dataset of the target associated with the first excitation slab and a second 3-D image dataset of the target associated with the second excitation slab from information received from the receiver coils. The first 3-D image dataset and the second 3-D image dataset, together defining a series of 3-D image datasets for each repetition time; and producing an image of the target from the series of 3-D image datasets. A method for analyzing a patient.

Abstract: A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.

Abstract: The present invention relates to compositions, articles of manufacture, methods of preparation thereof, methods of use thereof, etc., for enhancement of sexual pleasure, conditions, disorders, and diseases related to reproductive physiology and systems, especially of mammalian females. For instance, the present invention relates to all aspects of modulating the female sexual response, including female sexual dysfunction, such as female sexual arousal disorders (FSAD), orgasmic disorders, and sexual pain disorders, and enhancing female sexual pleasure and satisfaction of the female sexual experience. Accordingly, the present invention relates to compositions comprising botanical extracts, active agents, etc., which are useful to treat or affect any of the aforementioned conditions.

Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.

Abstract: A production process performance reporting system may include a plurality of print job processing resources and a computer-readable storage medium containing programming instructions for performing a method of providing a report of performance metrics in a document production environment. The method may include receiving job size information for print jobs and identifying a print job size distribution for the print jobs. Performance metrics such as, job turnaround time and inter-arrival time may be determined. It may be determined whether the print job size distribution exhibits a heavy-tail characteristic and a performance report may be prepared. If the print job size distribution does not exhibit a heavy-tail characteristic, the plurality of jobs may be processed with the print job processing resources based on the performance report.

Abstract: A method is provided for managing the scheduling of a plurality of print jobs for a print shop. The method includes obtaining a print job input stream including the plurality of print jobs. Each of the plurality of print jobs is scheduled for processing unless at least one of the plurality of print jobs is determined to be a disturbance job, the disturbance job causing delays in processing of other print jobs in the plurality of print jobs that would not occur but for the existence of the disturbance job in the print job input stream. The disturbance job is then assigned a processing related value that increases over time, and scheduling of the disturbance job is delayed until the processing related value exceeds a selected threshold value.

Abstract: This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.

Abstract: Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.

Abstract: A hammer-drive powder-actuated tool includes a hollow tool body extending along a front-to-rear direction, and a firing device disposed within a rear end portion of the tool body. The firing device includes a pin holder having a through hole extending along the front-to-rear direction, and a firing pin movable forwardly and rearwardly relative to the pin holder. The pin has a firing end portion that is disposed at a front end thereof and that extends into the through hole in the pin holder, and a central axis aligned with that of a rimfire cartridge along the front-to-rear direction. A front end of the firing end portion of the firing pin has a diameter larger than the inner diameter of the annular primer and smaller than the outer diameter of the annular primer.

Abstract: Methods and systems for detecting one or more anomalous devices are disclosed. For each of a plurality of devices, semi-structured data may be received from the device. For each pair of devices, of the plurality of devices, a similarity measurement may be determined between semi-structured data from a first device of the pair of devices and semi-structured data from a second device of the pair of devices. One or more anomalous devices may then be identified and one or more remedial actions may be performed for the one or more identified anomalous devices.

Abstract: A switch for selectively establishing a first conductive way between a first conductive fixed contact and a second conductive fixed contact or a second conductive way between the first conductive fixed contact and a third conductive fixed contact. The switch includes a housing and a pushbutton extending out of the housing and comprising a driving portion formed by an extension extending into the housing, the pushbutton being arranged, when an external force is applied to the pushbutton, to be moved relative to the housing between a first pushbutton active position in which the first conductive way is established and a second pushbutton active position in which the second conductive way is established.

Abstract: Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an ? adrenergic receptor agonist selected from selective ?1 adrenergic receptor agonist, selective ?2 adrenergic receptor agonist, non-selective ?1/?2 adrenergic receptor agonist, agents with ?2 adrenergic receptor agonist activity and combinations thereof, in a pharmaceutically acceptable carrier in order to treat and improve the cosmetic appearance of hemorrhagic (purpuric) lesions in the skin.

Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Abstract: An electrical switch with multiple switching channels may include a frame, a panel with which a pointing element comes into contact. The electrical switch may have a location element which locates the point of contact of the pointing element on the panel which may include a plurality of switching elements. The electrical switch may have a detection element which detects at least one control action independent of the position of the point of contact with the panel. The electrical switch may have an intermediate plate on which the panel acts in order to cause the change in state of the switching elements. The intermediate plate may be configured to cause the change in state of switching elements and detection element. The plate can be at least in part deformed in order to actuate the detection element after changing the state of the switching elements.

Abstract: The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the treatment of cancers and the inhibition of histone deacetylase activity.