Abstract: A multi-organizational information management system provides for full lifecycle tracking of business activities of a complex mix of governmental entities and business organizations by maintaining a secure database of data entities or records to track such activities. The system provides for secure sharing of information among the governments and organizations by controlling access to data entities based on organizational membership and assigned role of system users. The system provides flexible structural relationships among the various data entities. A graphic, web-based user interface of the system enables efficient access to the data entities for entry and update of specific data.

Abstract: The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 are defined in the specification. The invention is also directed to a method of selectively inhibiting P2X7 activity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (III), (IV) or (V) wherein R6, R7, R8, R9, R10, and R11 are defined in the specification.

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

Abstract: Trimellitic acid is produced by oxidation of pseudocumene in acetic acid at temperatures between 130 and 240° C. in the presence of a catalyst composition containing cobalt, manganese and bromine. The process comprises the stages of: (i) simultaneously feeding pseudocumene and air or an oxygen-containing gas into a solution containing acetic acid and the catalyst composition, at an addition rate resulting in an oxygen concentration in the off-gas of less than 8 vol %, and at a temperature and a pressure sufficient to result in 5 to 25 mol % of the total amount of oxygen required to oxidize the pseudocumene to trimellitic acid being consumed, and (ii) feeding air or an oxygen-containing gas into the reaction mixture obtained in stage (i) until essentially all of the pseudocumene has been consumed and a molar yield of trimellitic acid of at least 90% has been obtained. There is no supplementation of catalyst after stage (i).

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: The energy efficient ventilation system provides tempered air to an air to air heat exchanger, such as a heat pump. The system includes independent air intake sources from a tunnel, a structure, and the exterior of the structure that direct air to a control module. Regulators control the amount of air that enters the control module from the air intake sources. The control module mixes the intake air and distributes the tempered air to the structure and to the air to air heat exchanger.

Abstract: A massager device that provides a liquid applicator that dispenses a liquid and provides a massaging effect is disclosed. The massager device comprises a massage head adapted to engage a reservoir for storing a liquid, a liquid dispensing component engaged to the reservoir for applying the liquid, and a vibratory component for vibrating the massager device such that the user may simultaneously apply the liquid and provide a massaging effect.

Abstract: The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as multiple sclerosis or rheumatoid arthritis using autologous T cell vaccines. The invention is further directed to the diagnosis of T cell associated diseases.

Abstract: The present invention is related to a method for the manufacture of a nucleic acid molecule and compounds used therefore. The invention further provides a method of ligating, cleaving and immobilising oligonucleotides in order to manufacture nucleic acid molecules. The invention includes the steps wherein a first and second at least partially double-stranded oligonucleotides are ligated via their respective single-stranded overhangs. The ligation product may be immobilised to the surface via the modification that is provided on the first oligonucleotide. The immobilised ligation product is cleaved with the first type IIS restriction enzyme therein releasing an elongated oligonucleotide having an overhang. The elongated oligonucleotide may further be combined and ligated with a further at least partially double-stranded oligonucleotide to form a further ligated product that may be cleaved with a type IIS restriction enzyme releasing an elongated oligonucleotide having an overhang.

Abstract: The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “genomic record” or “GR” genes. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism. GR genes encode an operon-like cluster of VGAM genes. VGAM and viral GR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.

Abstract: A multi-cellular polypropylene container with a cut-scored region connecting the cells of the container is described. By varying the cut-score depths depending on the orientation of the plastic material, greater consistency in the tearability of the individual cells is achieved. One or more star-cut patterns may be provided between the cells. The star-cut patterns have curved edges that lead to the separation region. The curved edges provide a generally smooth surface that does not cut or snag the user.

Abstract: A method, apparatus and system for signal modulation. A plurality of pixels are selected in a pattern such that a first pixel group of the plurality of pixels is unpaired with a second pixel group of the plurality of pixels throughout the pattern in a portion of a video signal. The intensity of the plurality of the pixels is altered at a constant magnitude in the portion of the video signal pursuant to the pattern in a substantially invisible way.

Abstract: The present invention is directed to hollow core optical ring resonators (HCORRs), methods of fabricating HCORRs, and methods of using HCORRs in sensing applications. In particular, the evanescent field and whispering gallery modes of the HCORRs may be used to detect a target analyte within the hollow core of the HCORR. Other features of the present invention include utilizing the HCORR as part of a multiplex sensing device, including using the HCORR in capillary electrophoresis and chromatography applications.

Abstract: The system and method for streaming media to a viewer and managing the media comprises and an enhanced service routing processor (ESRP), a real time switch management system (RTSMS), a name routing processor (NRP), and a managed media switch (MMS). The system and method operate with a reservation server. The ESRP receives media from an owner, manages the media according to media rules and order rules defined by the owner, and distributes the media to one or more switches, such as the MMS, according to the media rules and the order rules. The RTSMS is configured to receive the media rules and to receive a viewer's media request via the reservation server. The RTSMS processes the media request according to the media rules and builds a reservation for the requested media. The RTSMS generates the reservation to the viewer and to the NRP. The NRP receives the reservation data from the viewer and from the RTSMS. The NRP processes the reservation data and locates an MMS that can stream the media to the viewer.

Abstract: A method for reproducibly analyzing mass spectra from different sample sources is provided. The method deconvolutes the complex spectra by collapsing multiple peaks of different molecular mass that originate from the same molecular fragment into a single peak. The differences in molecular mass are apparent differences caused by different charge states of the fragment and/or different metal ion adducts and/or reactant products of one or more of the charge states. The deconvoluted spectrum is compared to a library of mass spectra acquired from samples of known identity to unambiguously determine the identity of one or more components of the sample undergoing analysis.

Abstract: A keyed channel strut mounted connector device includes channel engagement structure connected to attachment structure. The channel engagement structure includes a key for engaging the channel, and an octagonal neck connecting the key to a boss surmounting the attachment structure. The neck includes clearance facets permitting the key to pass into the longitudinal channel, and relief facets defining support shoulders on the key for supporting the key on the inwardly turned sidewalls of a channel strut. Two pairs of opposed support shoulders permit installation of the device for supporting a run of cables or pipes parallel with the longitudinal axis of the strut, or rotation of the device 90° for supporting the cables or pipes transverse to the strut. By rotating the device 180° in either direction, the head and tail ends of the attachment structure can be reversed without changing the parallel or transverse orientation of the attachment structure.

Abstract: A method for modulating mark (20) within content signal (18) that has frames, where each of the frames has content lines and one or more measurable parameters, where each of the content lines has pixels, and where each of the pixels has a value, the method comprising selecting framesets from among the frames of the content signal; modulating at least two of the framesets; and causing mark (20) to be present within content signal (18) by at least modulating at least two of the framesets.