Abstract: The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel formulation comprising a fatty acid, an organic solvent which is a linear aliphatic ester, a silicone-based fluid, or a combination thereof, and an active ingredient that can protect the animal against one or more arthropod pests.

Abstract: A long-acting antiparasitic formulation suitable for topical application including: (a) 0.1-50% w/v an avermectin or milbemycin having activity against endo- and/or ectoparasites; (b) 1-50% v/v a di(C2-4 glycol) mono(C1-4 alkyl) ether; (c) an optional antioxidant; and (d) an optional skin acceptable volatile solvent q.s. v/v.

Abstract: An efficient synthesis of sulfonyl pyrazoles of formula I: wherein the ring of the formula (R5)-A-(SOmR4), m, R1 through R9 are as defined in the specification, comprising reacting a compound of formula II: wherein the ring of the formula (R5)-A-(SOmR4), m R1 through R9 are as defined above and wherein R10 is halo, (C1-C6)alkyl-SO3—, (C6-C10)aryl-SO3—, (C1-C6)alkyl-SO2—, or (C6-C10)aryl-SO2—; wherein each of said (C1-C6)alkyl component of said (C1-C6)alkyl-SO3— and (C1-C6)alkyl-SO2— radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C1-C6)alkyl component; with a compound of formula R3—H, wherein R3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.

Abstract: A compound of the formula XXXI or the pharmaceutically acceptable salt thereof; wherein R1, R2, and R3 are as defined herein and the compound is useful in the preparation or use of compounds that treat inflammation and other immune disorders.

Abstract: The present invention relates to 5-heterocyclo-pyrazoles of the formula I: wherein ring W, m, n, and R1 through R5 are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Abstract: A razor assembly having a razor cartridge designed for pivotal, swivel and torsional movement during shaving includes a handle and a flexible member having a first end connected to the handle at a pivot axis, a second free end extending beyond the handle and a longitudinal axis extending through the first and second ends of the flexible member. The razor cartridge, which has a major axis and one or more razor blades, is pivotally connected to the second free end of the flexible member for pivoting about an axis that is substantially parallel to the major axis of the razor cartridge. In addition, the second free end of the flexible member, and the razor cartridge pivotally connected thereto, are movable along an arcuate path centered at the pivot axis and are rotatable about an axis substantially parallel to the longitudinal axis of the flexible member.

Abstract: A shaving preparation that undergoes a change discernible to the user when the hair to be shaved has had time to absorb water and soften, when the shaving preparation has been sufficiently hydrated, after a period of time in which proper hair hydration would normally be expected to have been achieved, or any combinations thereof. Shaving preparations of this type advantageously alert the user when at least one desired shaving condition exists.

Abstract: A shaving razor has a blade carrier, which may be part of a replaceable blade cartridge, pivotally supported by a main component or handle assembly, the main component and the blade carrier having cooperating convex and concave arcuate bearing surfaces whereby the carrier is movable about the pivot axis by sliding movement of the convex and concave bearing surfaces over one another, and a spring mechanism both holds the convex and concave bearing surfaces in engagement with one another and resiliently biases the carrier in one direction about the pivot axis toward a limit position.

Abstract: Razor heads comprising at least one blade and a plurality of guard elements over the leading edge at a plurality of intermediate portions. According to preferred embodiments, the guard elements are integrally molded with at least one or more of a blade support, spacer element(s), forward guard member and cap member. The use of integrally molded guard elements facilitate efficient, quicker and less expensive manufacturing, provide greater design flexibility, and provide greater blade stability. Additionally, in preferred embodiments, when the molded guard elements are aligned with spacers, these guard elements do not interfere with the rinsability of the razor head. The intermediate guard elements also provide additional sites for the placement of shaving aids and other skin flow control materials such as materials having a relatively high coefficient of friction.

Abstract: Retail razor display packaging comprising a razor stand and a display card. The razor stand is preferably transparent and is designed to engage at least a portion of a display card so that a razor can be positioned on the razor stand and then connected to the display card in a manner which provides an attractive display. The razor stand permits a potential purchaser to view the razor prior to purchasing and then provides a convenient holder for the razor after purchasing and use.

Abstract: A combination shipping and display container includes a unitary blank of material foldable into a substantially rectangular container for receiving one or more items packed therein. The container has a top wall, a bottom wall, a front wall, a rear wall and first and second side walls. The container has a line of continuous perforations extending across the rear wall, the first side wall, the front wall and the second side wall for dividing the container into a first or tear away top section and a second or bottom section. The perforations in the first and second side walls define curved slopes extending between the rear wall and the front wall. The top section may be torn away from the bottom section along the perforations formed in the container for converting the bottom section into a display container for displaying the one or more items, commonly referred to as primary packages, packed in the container.

Abstract: A pouch containing a non-pressurized post-foaming gel, wherein the gel within the pouch is enclosed within an inert atmosphere, such as a nitrogen blanket, which protects the gel and prevents premature foaming and the separation of the gel's components. Upon opening the pouch and discharging the contents, the heat of the user's skin allows a low boiling point hydrocarbon, such as isopentane, to cause the gel to foam, thus providing the consumer with an instant benefit which could include cleansing, moisturizing, increasing shave comfort, wound treatment, etc. Further, the process to produce a gel which is suitable for use in a single use delivery system involves the steps of containing the gel in a jar, spraying the gel with nitrogen to remove the air from the jar, and then swirling the jar to form a non-aerated gel without weight variation problems.

Abstract: The present invention is directed to a wet shaving system having an electronic indicator for indicating when the blades are becoming dull and in need of replacement. As razor blades dull, the user must exert greater force during shaving to achieve a satisfactory shave. Upon exertion of this extra force, a piston which is adjacent to the blades moves away from the blades in response to the increased forces encountered by the blades during shaving. Upon moving a sufficient distance, the piston pushes into an electronic device, such as a potentiometer, which initiates a signal processing circuit which in turn activates an indicator, such as a light-emitting diode. The activation of the indicator is a signal to the user to replace the blades.

Abstract: In a shaving razor using a blade cartridge, the reusable assembly of the razor includes a guard element and the blade cartridge is designed with no parts located in front of the blade edge or edges, and when the blade cartridge is installed in the reusable assembly, the guard element of the reusable assembly becomes located in front of the blade edge or edges of the blade cartridge to cooperate with the blade edges in a customary way to stretch the skin and erect the beard hairs in advance of the cutting edge. The blade cartridge is also movable about two different pivot axes to improve the safety of the razor during use.

Abstract: A shaving system which comprises a razor, a razor head and a mechanism for vibrating one or more skin-engaging elements at a frequency ranging from about 15,000 hertz to about 2,000,000 hertz.

Abstract: Shaving systems are designed to provide greater uniformity to shaving forces over the skin-engaging portion of the skin-engaging element, such as a blade, guard element or cap member. According to one embodiment, at least one, and preferably a plurality of flexible blades are movably connected to a support by biasing members. One embodiment comprises a razor head comprising a plurality of blades which are movably connected to a flexible support structure in a manner which permits movement of the blades independent of the flexing of the blade(s) or the flexible support. According to another embodiment, at least one and most preferably a plurality of blades are connected to a support block which is movably supported in a “floating” manner within a housing by biasing members.

Abstract: An elastomeric spring system having non-linear force-deflection characteristics and low rebound is provided. The system comprises a housing and a plurality of first and second spring members movably disposed in alternating relationship within a bore defined by the housing. The first and second spring members are preferably formed from polyurethane such as the two part castable urethanes made from polyether-isocyanate or polyester-isocyanate prepolymers cured with organic diamine or polyol materials. When subject to a force along the axis of deflection, the first spring member is adapted to expand and progressively envelope the second spring members until the hemispherical ends of two of the first spring members meet within the first spring member, thereby causing the force-deflection characteristics of the spring to be nonlinear.