Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth fire disclosed.
Type:
Grant
Filed:
April 20, 1995
Date of Patent:
September 17, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
Abstract: The invention pertains to (pyrrolidinyl)phenyl carbamates and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the carbamates and related compounds, or compositions thereof are disclosed.
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
April 20, 1995
Date of Patent:
August 27, 1996
Assignee:
Hoechst Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Harner, Brian S. Freed, Gregory H. Merriman
Abstract: Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.
Type:
Grant
Filed:
August 24, 1994
Date of Patent:
August 6, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Raymond W. Kosley, Jr., Robert J. Cherill, Gerard O'Malley
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
April 21, 1995
Date of Patent:
July 9, 1996
Assignee:
Hoechst Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
April 21, 1995
Date of Patent:
July 9, 1996
Assignee:
Hoechst Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
May 23, 1994
Date of Patent:
May 21, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
Abstract: Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.
Type:
Grant
Filed:
October 24, 1991
Date of Patent:
April 23, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Lawrence L. Martin, Joseph F. Payack, Salvatore M. Brucato
Abstract: Novel 9-aminotetrahydroacridines and related compounds, intermediates and processes for the preparation thereof, and a method of relieving memory dysfunction are disclosed.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
March 26, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Gregory M. Shutske, Kevin J. Kapples, John D. Tomer
Abstract: Novel 5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing compounds or compositions thereof are disclosed.
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
May 23, 1994
Date of Patent:
January 30, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Harmer, Brian S. Freed, Gregory H. Merriman
Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Type:
Grant
Filed:
May 23, 1994
Date of Patent:
January 30, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
John J. Tegeler, Barbara S. Rauckman, Russell R. L. Harmer, Brian S. Freed, Gregory H. Merriman
Abstract: Novel compositions comprising an antiandrogenic compound of the formula ##STR1## wherein R is COR.sub.1 wherein R.sub.1 is loweralkyl and a vehicle comprising a metabolism modulator and a polar organic solvent, and a method of controlling the membrane permeation and metabolism of the compound thereof are disclosed.
Type:
Grant
Filed:
September 17, 1993
Date of Patent:
January 9, 1996
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Kwon H. Kim, Barry Koplowitz, Norman L. Henderson
Abstract: This application is a continuation-in-part of pending U.S. patent application Ser. No. 388,437, filed Aug. 2, 1989.This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring or 4 to 6 carbons or a spiro-fused aryl cycloalkane or heterocycloalkyl selected from the group consisting of piperidine and tetrahydropyran; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and, where applicable the optical, geometrical and stereoisomers and racemic mixtures thereof.
Type:
Grant
Filed:
May 13, 1994
Date of Patent:
November 7, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals, Inc.
Inventors:
Richard C. Effland, David G. Wettlaufer
Abstract: This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.
Type:
Grant
Filed:
May 25, 1994
Date of Patent:
October 3, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Richard C. Effland, Larry Davis, Gordon E. Olsen
Abstract: Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.
Type:
Grant
Filed:
May 5, 1994
Date of Patent:
August 8, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals Inc
Inventors:
Helen H. Ong, Nicholas J. Hrib, Joseph Perez, John G. Jurcak
Abstract: A compound of the formula ##STR1## wherein R.sup.1 is hydrogen, loweralkyl, phenyl, phenyl substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups, phenylloweralkyl or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; R.sup.2 is loweralkyl, furanylloweralkyl, thienylloweralkyl, pyrrolylloweralkyl, pyridinylloweralkyl, phenylloweralkyl, or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m is 0 or 1; n is 1 or 2; an optical isomer thereof or a salt thereof.
Type:
Grant
Filed:
November 8, 1993
Date of Patent:
July 4, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Lawrence L. Martin, Denise M. Flanagan, Joseph F. Payack
Abstract: Novel 2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds, intermediates and processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.
Type:
Grant
Filed:
November 8, 1993
Date of Patent:
July 4, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Lawrence L. Martin, Denise M. Flanagan, Joseph F. Payack
Abstract: There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
Type:
Grant
Filed:
September 15, 1994
Date of Patent:
June 27, 1995
Assignee:
Hoechst-Roussel Pharmaceuticals Inc.
Inventors:
Gregory M. Shutske, Kevin J. Kapples, John D. Tomer, IV