Patents Represented by Attorney Raymond R. Wittekind

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  • 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides
    Patent number: 4952588
    Abstract: Novel 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides, processes for the preparation thereof, and methods for treating pain and inflammation utilizing compounds and compositions thereof are disclosed.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: August 28, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, R. Richard L. Hamer
  • Aminoalkylthiodibenzoxepins and pharmaceutical use
    Patent number: 4943571
    Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: July 24, 1990
    Assignee: Hoechst-Roussel Phamraceuticals Inc.
    Inventors: Helen H. Ong, Vernon B. Anderson, James A. Profitt
  • Pyrido[3,4-b][1,4]benzoxazepines
    Patent number: 4940704
    Abstract: Novel pyrido[3,4-b][1,4]benzoxazepines, intermediates for the preparation thereof, and methods for treating depression, alleviating pain, and relieving memory dysfunction are disclosed.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: July 10, 1990
    Assignee: Hoechst-Roussel Pharmaceutical Inc.
    Inventors: Richard C. Effland, Joseph T. Klein
  • Process for the preparation of novel oxolabdanes
    Patent number: 4933476
    Abstract: Novel oxolabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: June 12, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Nicholas J. Hrib
  • Laminar structure for administering a chemical at a controlled release rate
    Patent number: 4931281
    Abstract: A laminar structure for administering a chemical at a controlled release rate is disclosed. The structure comprises a backing member which acts as a boundary through which the chemical does not pass. Contacting at least a portion of the backing member is a chemical containing layer having therein a first chemical portion and a second chemical portion. The first and second chemical portions comprise a mixture of chemical in a first concentration transport mode and a second concentration transport mode. The mixture being in a ratio to give a desired chemical release rate from the chemical containing layer.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: June 5, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Kwon H. Kim, Norman L. Henderson, Yie W. Chien
  • 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
    Patent number: 4929615
    Abstract: Novel 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines, processes for the preparation thereof, and a method of treating depression utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: May 29, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Carbamoyloxylabdane compounds useful in reducing intraocular pressure
    Patent number: 4920146
    Abstract: Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: April 24, 1990
    Assignee: Hoechst Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill, Gerard O'Malley
  • 1-(Benzo[b]thienyl)-2-(thienyl)ethenes and related compounds useful as anti-inflammatory agents
    Patent number: 4904674
    Abstract: Novel 1-(benzo[b]thienyl)-2-(thienyl)ethenes, processes for the preparation thereof, and methods of reducing inflammation utilizing compounds and compositions there are disclosed.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: February 27, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Joseph F. Payack
  • Hydrazinocarbonyloxylabdanes for treating cardiac failure
    Patent number: 4883793
    Abstract: Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: November 28, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Gerard J. O'Malley
  • Oxolabdanes
    Patent number: 4883885
    Abstract: Novel oxolabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: November 28, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Nicholas J. Hrib
  • 1-carbonyl derivatives of 4-aryl-4-aryloxypiperidines
    Patent number: 4853384
    Abstract: 1-Carbonyl derivatives of 4-aryl-4-aryloxypiperidines and methods for alleviating pain and treating convulsions utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: August 1, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Grover C. Helsley, Larry Davis, Gordon E. Olsen
  • Labdanes, pharmaceutical compositions, and their use
    Patent number: 4851397
    Abstract: Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: June 10, 1988
    Date of Patent: July 25, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]-oxazepin-5(6H)-ones
    Patent number: 4800200
    Abstract: Novel 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]oxazepin-5(6H)-ones and methods for treating hypertension utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: January 24, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: John J. Tegeler, Kirk D. Shoger
  • Biotinylating agents
    Patent number: 4798795
    Abstract: Compounds having a dithiopyridyl moiety linked to a biotin moiety are useful as thiol specific biotinylating agents. The biotin label can be cleaved in a reducing environment to yield the native thiol.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: January 17, 1989
    Assignee: Hoechst Celanese Corporation
    Inventor: Gerald F. Sigler
  • Biotinylating agents
    Patent number: 4794082
    Abstract: Compounds having a dithiopyridyl moiety linked to a biotin moiety are useful as thiol specific biotinylating agents. The biotin label can be cleaved in a reducing environment to yield the native thiol.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: December 27, 1988
    Assignee: Hoechst Celanese Corporation
    Inventor: Gerald F. Sigler
  • 3-methylenespiro (benzofuranpiperidines)
    Patent number: 4788201
    Abstract: Novel 3-methylenespiro[benzofuran-2(3H),4'-piperidines], intermediates and processes for the preparation thereof and methods for reducing blood pressure utilizing the compounds and compositions thereof are disclosed.
    Type: Grant
    Filed: January 22, 1987
    Date of Patent: November 29, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Raymond W. Kosley, Jr.
  • 1-aryl-3-quinolinecarboxamide
    Patent number: 4786644
    Abstract: Novel 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides, processes for the preparation thereof, and methods for treating pain and inflammation utilizing compounds and compositions thereof are disclosed.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: November 22, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, R. Richard L. Hamer
  • Aminoalkylthiodibenzothiepins
    Patent number: 4775672
    Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: October 4, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Helen H. Ong, Vernon B. Anderson, James A. Profitt
  • Haloalkylthiodibenzothiepins
    Patent number: 4775682
    Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: October 4, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Helen H. Ong, Vernon B. Anderson, James A. Profitt
  • Aminoalkylthiodibenzothiepins
    Patent number: 4775683
    Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: October 4, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Helen H. Ong, Vernon B. Anderson, James A. Profitt