Patents Represented by Attorney Robert E. Allen
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Patent number: 4394919Abstract: A closure for containers which is inexpensively and easily manufactured and is readily removeable in whole or in part to gain access to contents in the container. The closure comprises a generally flat cap member sealed at its periphery to the mouth of the container. An upstanding tubular member on the surface of the cap is partially surrounded by a score line in the cap and the score line preferably continues all around the cap near its periphery. The tubular member preferably has rigidifying means in its closed top and side walls which can be readily flexed inwardly so that the tubular member can be firmly grasped and pulled to readily initiate a rupture in the score line at a stress-concentrating focal point on that portion of the score line adjacent the tubular member. The cap can then be easily removed by continued pulling of the tubular member.Type: GrantFiled: July 23, 1981Date of Patent: July 26, 1983Assignee: Cutter Laboratories, Inc.Inventors: Raymond D. von Alven, Lee E. McGill
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Patent number: 4382679Abstract: An improved method for testing the integrity of containers and closures for same is disclosed which is simple, easy to perform, and possesses a high degree of sensitivity. The method comprises immersing a container (whose walls are substantially transparent and in which a substantially transparent liquid is stored) into a solution of a dye under conditions which will favor the passage of the dye through any leaks present in the container or closure and into the liquid. The container is then placed in the path of a laser beam emitting a wavelength which approximates the fluorescent excitation frequency of the dye. If the color of the beam transmitted through the liquid is that which is characteristic for the fluorescing dye, a leak in the system is indicated.Type: GrantFiled: October 6, 1980Date of Patent: May 10, 1983Assignee: Cutter Laboratories, Inc.Inventor: Charles E. Lee
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Patent number: 4361148Abstract: A means for releasable sealing a flexible conduit is disclosed, having particular use in a conduit connecting multiple blood bags. The conduit contains within a portion of itself a flexible strip or tubular insert. This portion of the conduit is positively closed by folding it back on itself and the closed portion is maintained by a clamping or restraining member. Upon release of the clamping member following a heat sterilization procedure, the conduit is readily opened for fluid flow therethrough. The conduit, which without the insert would normally be fused together as a consequence of the heat sterilization, is open by virtue of the insert being made of a material which does not fuse together under these conditions.Type: GrantFiled: December 3, 1980Date of Patent: November 30, 1982Assignee: Cutter Laboratories, Inc.Inventors: John E. Shackleford, Willie J. Lewis
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Patent number: 4355783Abstract: An improvement in a flow control device for permitting fine adjustment of flow rates of fluid in tubing and maintaining established rates of flow. The device includes a clamping member pivotally mounted adjacent a clamping surface and a tubing-engaging surface on the clamping member which progressively closes the orifice of tubing as the clamping member is rotated in one direction. Coacting means on the clamping member cooperate with actuating means on a force-inducing member mounted for rotational movement on the body of the device. The coacting means is located at a point from the point of pivotal attachment of the clamping member which is at least twice the distance from the pivotal attachment to the tubing-engaging surface. Thus a large movement at the coacting point translates into a small movement of the tubing-engaging surface and results in fine adjustment of flow rates.Type: GrantFiled: February 17, 1981Date of Patent: October 26, 1982Assignee: Cutter Laboratories, Inc.Inventor: Marius J. Morin
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Patent number: 4334535Abstract: A unit for rapid priming and flow of liquid through the unit is disclosed. The unit comprises a connector for communicating with liquid in a sealed container, the connector having an exit orifice around which is secured one end of a primer tube. The other end of the primer tube is joined to a pooling conduit. The diameter of the primer tube is greater than the diameter of a drop of liquid released from the orifice and the diameter of the pooling conduit is no greater and preferably slightly less than the diameter of the drop of liquid. Multiple units can be joined to a common tube of enlarged diameter which leads into a pooling and dispensing container.Type: GrantFiled: August 12, 1980Date of Patent: June 15, 1982Assignee: Cutter Laboratories, Inc.Inventors: David A. Wilson, Frank J. Serany
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Patent number: 4328946Abstract: An improvement in a flow control device for permitting fine adjustment of flow rates of fluid in tubing and maintaining established rates of flow. The device includes a clamping member pivotally mounted adjacent a clamping surface and a tubing-engaging surface on the clamping member which progressively closes the orifice of tubing as the clamping member is rotated in one direction. Coacting means on the clamping member cooperate with actuating means on a force-inducing member mounted for rotational movement on the body of the device. The coacting means is located at a point from the point of pivotal attachment of the clamping member which is at least twice the distance from the pivotal attachment to the tubing-engaging surface. Thus a large movement at the coacting point translates into a small movement of the tubing-engaging surface and results in fine adjustment of flow rates.Type: GrantFiled: February 17, 1981Date of Patent: May 11, 1982Assignee: Cutter Laboratories, Inc.Inventor: Marius J. Morin
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Patent number: 4307868Abstract: An improvement in a flow control device for permitting fine adjustment of flow rates of fluid in tubing and maintaining established rates of flow. The device includes a clamping member pivotally mounted adjacent a clamping surface and a tubing-engaging surface on the clamping member which progressively closes the orifice of tubing as the clamping member is rotated in one direction. Coacting means on the clamping member cooperate with actuating means on a force-inducing member mounted for rotational movement on the body of the device. The coacting means is located at a point from the point of pivotal attachment of the clamping member which is at least twice the distance from the pivotal attachment to the tubing-engaging surface. Thus a large movement at the coacting point translates into a small movement of the tubing-engaging surface and results in fine adjustment of flow rates.Type: GrantFiled: February 17, 1981Date of Patent: December 29, 1981Assignee: Cutter Laboratories, Inc.Inventor: Marius J. Morin
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Patent number: 4294249Abstract: An injection site is disclosed comprising a self-sealing, puncturable member of resilient material and a housing wherein the puncturable member is compressibly confined by a swage-molded edge on the top of the housing. The injection site may be attached to an injection-receiving receptacle such as a medicament injection device as used in an assembly for intravenous administration.Type: GrantFiled: October 18, 1979Date of Patent: October 13, 1981Assignee: Cutter Laboratories, Inc.Inventors: Neil J. Sheehan, Melvin H. Norman
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Patent number: 4280497Abstract: A plastic bag containing a platelet concentrate is disclosed wherein the viability of platelets remains at a high level even after storage at 22.degree. C. for up to five days. The bag in which the platelet concentrate is stored comprises walls of polyvinyl chloride film containing tri 2-ethylhexyl trimellitate as plasticizer together with epoxidized vegetable oils for heat stabilization of the film. The film may also contain metal soaps in preferred formulations.Type: GrantFiled: October 9, 1979Date of Patent: July 28, 1981Assignee: Cutter Laboratories, Inc.Inventors: Willis L. Warner, Edward J. Nelson
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Patent number: 4265425Abstract: An improvement in a flow control device for permitting fine adjustment of flow rates of fluid in tubing and maintaining established rates of flow. The device includes a clamping member pivotally mounted adjacent a clamping surface and a tubing-engaging surface on the clamping member which progressively closes the orifice of tubing as the clamping member is rotated in one direction. Coacting means on the clamping member cooperate with actuating means on a force-inducing member mounted for rotational movement on the body of the device. The coacting means is located at a point from the point of pivotal attachment of the clamping member which is at least twice the distance from the pivotal attachement to the tubing-engaging surface. Thus a large movement at the coacting point translates into a small movement of the tubing-engaging surface and results in fine adjustment of flow rates.Type: GrantFiled: November 6, 1978Date of Patent: May 5, 1981Assignee: Cutter Laboratories, Inc.Inventor: Marius J. Morin
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Patent number: 4252117Abstract: An improvement in an injection bulb device in an assembly for administration of parenteral solutions is disclosed. The device is a tubular elastomeric member having an enlarged intermediate section whose bore is larger than the bores in the two end sections. A plurality of flat-surfaced projections or rings extend inwardly from the walls of the bores in the end sections which compressively grip the end of a rigid needle adapter and flexible tubing inserted respectively within these end sections. The end of the tubing flares outwardly into the enlarged bore of the intermediate section and this configuration assists in increasing the strength of mechanical engagement between the tubing and the injection bulb.Type: GrantFiled: October 9, 1979Date of Patent: February 24, 1981Assignee: Cutter Laboratories, Inc.Inventor: Neil J. Sheehan
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Patent number: 4251510Abstract: Plasma Protein Fraction substantially free of bradykinin, kininogen and prekallikrein activators is obtained by treating Cohn Supernatant II plus III at about neutrality with a siliceous substance for a period of time sufficient to bring about essentially complete conversion of intrinsic kininogen into bradykinin. Subsequently, after being separated from Cohn Fraction IV-1, the Plasma Protein Fraction is reconstituted and held for a period of time sufficient to allow substantially complete destruction of bradykinin by kininase. Methods are disclosed for the destruction of prekallikrein activators which may be present in Plasma Protein Fraction.Type: GrantFiled: August 15, 1979Date of Patent: February 17, 1981Assignee: Cutter Laboratories, Inc.Inventor: Donald L. Tankersley
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Patent number: 4246898Abstract: A syringe for dispensing medicaments includes a barrel with a discharge end and an open end for receiving a plunger. The plunger has a head with engagement means for receiving a plunger seal. The plunger seal is a tubular member which is severed along a generally longitudinal direction providing a slit which allows the seal to be expanded for fitting onto the plunger head. Preferably the slit has an irregularity at the forward end which provides a locking configuration which prevents the seal from being twisted away from its normally tubular shape. For metered dose application, the shank of the plunger may be threaded for the desired placement of a stop ring threaded on the shank. In one form, the ring and barrel have interlocking means to prevent the ring from moving backward when pressure is applied to the plunger after the ring has reached the barrel.Type: GrantFiled: July 23, 1979Date of Patent: January 27, 1981Assignee: Cutter Laboratories, Inc.Inventors: Louis J. Travalent, Herbert Arenson
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Patent number: 4244365Abstract: An overpressure device is disclosed for use in a liquid infusion set for the purpose of detecting excessive pressures which may occur during infusion. The device comprises a tubular member with an inlet and an outlet, a closed pressure chamber and a bridging portion containing a small bore passage which connects the pressure chamber with the tubular member. In a preferred form, the interconnecting passage takes a tortuous path. An optical sensor positioned on the pressure chamber will detect the presence of liquid at a predetermined position in the chamber, when the liquid rises as a result of excessive pressure in the set, and respond by stopping the flow of liquid in the set.Type: GrantFiled: March 26, 1979Date of Patent: January 13, 1981Assignee: Cutter Laboratories, Inc.Inventors: Lee E. McGill, Susan J. Watkins
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Patent number: 4207988Abstract: Improvements in inner and outer closures for containers are disclosed. The outer closure is characterized by a cap member having a top wall, a side wall and a base adapted for sealing to the neck of a container. Two score lines extend across the top wall with finger gripping means attached at the apex where the two score lines meet. One score line extends down the side wall to connect with a third score line near the base which extends completely around the cap. The other score line extends down the side wall to an intermediate position and diverges away and terminates a short distance from the one score line. By pulling on the finger gripping means, the entire cap member above the third score line is removed in one piece. The inner closure comprises a plastic member sealed at its periphery to the mouth of the neck and includes a vertically aligned spike-entry port and an additive port which is oriented at an angle away from the entry port.Type: GrantFiled: May 18, 1979Date of Patent: June 17, 1980Assignee: Cutter Laboratories, Inc.Inventors: Myron R. Prouty, Colin J. Nichols, Norman A. Brown, Stephen P. Sutter
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Patent number: 4204604Abstract: An improvement in a closure system for containers in which a cap member sealed at its base to an annular flange about the neck of the container is removeable by a cutting ring. The cap includes an upwardly projecting brim at the base separated from the side wall of the cap to provide an annular groove. The groove has at least one tapered recess. The cutting ring which can be positioned around the side wall of the cap has at least one depending tab with an inwardly directed sharpened projection. Normally, the tab rests in the recess of the groove. Upon rotation of the cutting ring, the tab is forced inwardly causing the sharpened projection to sever the side wall of the closure.Type: GrantFiled: April 30, 1979Date of Patent: May 27, 1980Assignee: Cutter Laboratories, Inc.Inventors: Marius J. Morin, Colin J. Nichols, Myron R. Prouty
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Patent number: 4195632Abstract: An improvement in a fluid flow valve is disclosed. The valve comprises a combination of flexible tubing joined to a tubular member having a membrane closing off the passageway in the tubular member. A pointed spike having at least three radially projecting ribs extending longitudinally is located within the tubing adjacent the membrane and is movable by external manipulation of the tubing whereby the spike ruptures the membrane and creates a passageway permitting fluid to flow freely through the tubular member and adjoining tubing.Type: GrantFiled: May 3, 1978Date of Patent: April 1, 1980Assignee: Cutter Laboratories, Inc.Inventors: Wendell R. Parker, Mark H. Silverman, Willis L. Warner
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Patent number: 4187558Abstract: Surgically implantable skeletal ligament having secured thereto at least one deformable collar having a velour-like outer surface adapted to invite tissue ingrowth. In use, the collar portion of the ligament is positioned within a surgically prepared passageway in a bone to protect the ligament from bone abrasion and to assist in ligament attachment by accepting tissue ingrowth into the velour-like surface.Type: GrantFiled: October 25, 1977Date of Patent: February 12, 1980Assignee: Cutter Laboratories, Inc.Inventors: Burton L. Dahlen, James A. Stubstad
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Patent number: 4186192Abstract: Composition comprising an aqueous solution of immune serum globulin and maltose, the amount of maltose being sufficient to inhibit "shedding" of the globulin with time.Type: GrantFiled: December 18, 1978Date of Patent: January 29, 1980Assignee: Cutter Laboratories, Inc.Inventors: John L. Lundblad, Willis L. Warner, Peter M. Fernandes
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Patent number: D260427Type: GrantFiled: March 26, 1979Date of Patent: August 25, 1981Assignee: Cutter Laboratories, Inc.Inventors: Lee E. McGill, Susan J. Watkins